A. H. Sturtevant: A History Of Genetics

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Chapters 1 to 10 Overview A History of Genetics by A.H. Sturtevant provides a brief history of work prior to Mendel and the author’s firsthand account of the events and research that helped shape the field of genetics. Early on, various hypotheses were beginning to be formulated by scientists such as Aristotle, Hippocrates, and Darwin. These include pangenesis, hybridization, and human inheritance which provided Mendel with some ideas to develop his own understanding of heredity. Also, the theory of inheritance and human pedigrees was developed by Maupertuis.

Mendel conducted experiments using the pea plant and developed different modes of inheritance and the expected ratios of offspring. At first, his results were questioned, mostly by Fisher, due to their extreme accuracy. Mendel’s work was largely forgotten until 1900 due to the development of the theory of evolution. During this time, however, there were advances in genetics that helped add credibility to Mendel’s work. Weissman developed germ-plasm theory and other scientists such as Flemming and Strasburg began to recognize chromosomes as the bearers of genetic material and understand their
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It is an X-linked recessive disorder that is most common in children, afflicting 1 in 35,000 boys1, 2. Most affected patients have inherited or spontaneous deletions in the dystrophin gene that disrupts translation and results in incomplete proteins. Sufferers of DMD have difficulty climbing stairs, muscle weakness in arms and neck, and progressive muscle-wasting1. It appears that error in gene expression and heredity are the two main causes of DMD. DMD, to this point, has no cure and after identifying the location of the DMD gene mutation, the goal is to restore transcription or to at least restore some type of dystrophin

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