6-OHDA Case Study

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CHAPTER 2 – ANIMAL MODELS
5. Animal models:
5.a. Neurotoxic Models:
5.a.1. 6- Hydroxydopamine model:
One of the most frequently used toxin-based animal model is 6-OHDA. It was first isolated in 1950. It is frequently used in rats. It shows affinity for catecholaminergic transporter. For example, norepinephrine transporter and dopamine transporter. Though the structure of 6-OHDA is similar to dopamine but the existence of excess amount of hydroxyl group makes it toxic to dopaminergic neurons. Catecholaminergic neurons are damaged by a combined effect of 6-OHDA, ROS and quinones. This effect leads inflammation in the brain which exists over time. All the features of Parkinson Disease are not mimic by this model. Reduced amount of dopamine, loss of cell of nigral dopamine, lack of neurobehavioral have been achieved by this model.
The 6-hydroxydopamine (6-OHDA) used to symbolize a important topical gadget used mainly in the modeling of the Parkinson's illness in the rat. We know that intracerebral infusion of 6-OHDA has a massive destruction of nigrostriatal dopaminergic neurons in the brain. It is primarily used to present at motor and show the biochemical dysfunctions in Parkinson's disease. Subsequently, extra delicate fashions of partial dopaminergic degeneration have been developed with the purpose of revealing finer motor scarcity. The
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Not only atypical but also typical antipsychotic causes drug induced parkinsonism. Typical antipsychotics include chlorpromazine, promazine, fluphenazine, pimozide gives drug induced parkinsonism. Typical antipsychotics show their effect on the dopamine receptors that are widely distributed in the stratum of the brain. For this reason, all the patients who are taking drugs of this class may have a risk for developing Parkinson. Atypical antipsychotic such as Risperidone causes parkinsonism as it binds to D2 receptors in a dose dependent

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