Synthesis Of 6-Deoxycellulose Derivatives Lab Report

Improved Essays
T. Heinze et. al. reported the synthesis of new 6-deoxy-6-pheylethylamino cellulose derivatives with DSamino 0.4-0.6 by nucleophilic displacement of cellulose tosylates (DSTos 0.74 and 1.29) with a racemic mixture of 1-phenylethylamine under homogeneous conditions, in DMF/H2O82, scheme 30. The optical properties of these deoxyamino cellulose derivatives was studied. A regioselective synthesis of 6-amino-6-deoxycellulose, 6-N-sulfonated, and 6-N-carboxymethylated deoxycellulose were described by C. Liu et. al, by replacement of the C-6 tosyl groups by azide groups, that were reduced by (LiAlH4) to the corresponding amino group. The amino functionalized cellulose underwent further sulfonation, and carboxylation, scheme 3183. Novel …show more content…
al. prepared new aminocellulose derivatives by nucleophilic substitution reaction with ethylenediamine (EDA) and selected oligoamines starting from 6(2)-O-tosylcellulose (DSTos= 0.8 that reacted with (EDA), (DETA), (DPTA), (TETA). All the synthesized aminocellulose tosylates were soluble in water, and their transparent films formed complexes with Cu2+ ions, and used to immobilize glucose oxidase enzyme86, scheme 34. Liu et al. studied the effect of temperature and solvent on the nucleophilic substitution reactions of tosyl cellulose by butylamine and pyridine. The reactions were conducted at different temperatures (25, 50, 75 and 100 oC). The highest regioselective substitution at C-6 was achieved at 25 and 50 oC. While the substitution at C-2 occurred at the higher temperature and the rate of substitution in neat butylamine is higher than that in the presence of DMSO. The substitution of tosyl group by pyridine on C-6 only proceeded by boiling in pyridine at 100 oC for 90 h, and on C2 at 145 oC, scheme …show more content…
Then the nanoparticles with narrow size distribution and diameter of 76, 111 and 176 nm were formulated by the dialysis method. The nanoparticles were labeled through covalent attachment to rhodamine dye for in vitro cellular uptrake studies. The safety toxic profile, stability and the enhanced cellular uptake of the particles by various cell lines made them suitable material for bio-medical applications, scheme 3991. P. H. Elchinger et al. successfully cross-linked starch with cellulose. Where Azide cellulose prepared from tosyl cellulose was cross-linked with propargyl starch using Cu(I) as a catalyst, scheme 4092. The benzoxazine-modified cellulose polymer was obtained by grafting benzooxazine to tosyl cellulose. The new cellulosic polymer is characterized by its resistance to flame compared to the pure cellulose fiber, scheme 4193. Aiming to develop a highly cost-effective colorimetric assay for pathogenic DNA detection, D. Saikrishnan et al. were able to immobilize sulfhydryl-modified oligonucleotide probes complementary to a segment of pathogenic bacterial DNA sequence IS6110 from Mycobacterium tuberculosis on the surface of tosyl

Related Documents

  • Superior Essays

    Leukocyte Gcrete Lab Report

    • 2582 Words
    • 11 Pages

    (Tokyo), 8 (3), 239–242. 40. Szasz, G. (1967) Comparison between p-nitrophenyl glucuronide and phenolphthalein glucuronide as substrates in the assay of β-glucuronidase. Clin. Chem., 13 (9), 752–759.…

    • 2582 Words
    • 11 Pages
    Superior Essays
  • Improved Essays

    peucetius and functionally characterized. Moreover, its biotechnological application for the production of diverse classes of O-methoxy natural products was experimented and investigated. Among these substrates both in the in vitro and in vivo bioconversion experiments, 7,8-dihydroxyflavone showed significant product conversion and was further analyzed by NMR study and confirmed as 7-hydroxy 8-O-methoxyflavone. Fermentation bioconversion assay was also performed with 7,8-DHF. Moreover, while analyzing the in vivo reaction mixtures by HR-QTOF-LC-ESI/MS, the mass fragments of O-methyl 3-hydroxyflavone, O-methyl phloretin, O-methyl luteolin, three mono- di- and tri-methylated genisteins, O-methyemodin and aloe-emodin were detected.…

    • 986 Words
    • 4 Pages
    Improved Essays
  • Great Essays

    Compound 3b Lab Report

    • 889 Words
    • 4 Pages

    Many 2,3 disubstituted quinazolinone derivatives have good antimicrobial and antifungal activities [19,20]. On the other hand substitution at 3rd position of bromo quinazolinone derivatives with phenyl ring show potential antimicrobial and antifungal activities [21,22]. Chacones, pyrazole, isoxazole and thiopyrimidine have antibacterial and antifungal activities [23-26]. Continuation of our research program which aim to synthesis of new biologically active quinazolin-4-one derivatives [4-8, 22], we synthesized new bromo quinazolinone derivatives substituted at 3rd position with chalcones,pyrazole, isoxazole or thio pyrimidine moiety bearing para chloro phenyl moiety at position 2. 2.…

    • 889 Words
    • 4 Pages
    Great Essays
  • Improved Essays

    (1) They can be installed by peracylation of the nucleoside followed by chemoselective O-deacylation (Schaller et al., 1963 ; Rigoli et al., 2009). (2) “Transient” protection approach (Ti et al., 1982) has been widely used. In this procedure, the nucleoside is persilylated using a silylating agent, and the acyl function is installed on the amino group using the corresponding acid chloride or acid anhydride. (3) Some acyl functions such as benzoyl, α-phenylcinnamoyl, and naphthaloyl are directly incorporated on the nucleobase using the corresponding anhydride (Watanabe and Fox, 1966; Bhat et al., 1989). Zhu et al.…

    • 1630 Words
    • 7 Pages
    Improved Essays
  • Superior Essays

    J. Biol. Chem., 173 (2), 449–456. 39. Kato, K., Yoshida, K., Tsukamoto, H., Nobunaga, M., Masuya, T., and Sawada, T. (1960) Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity. Chem.…

    • 2123 Words
    • 9 Pages
    Superior Essays
  • Improved Essays

    The combined ethyl acetate layers washed with water and dried over MgSO4. To this ethyl acetate layer, 2ml of glacial acetic acid added and stirred the reaction mixture at room temperature to afford acetate salt of 1-(2-amino-1-(4-methoxyphenyl)ethyl) cyclohexanol…

    • 1444 Words
    • 6 Pages
    Improved Essays
  • Great Essays

    Valolaris Solanacea

    • 1502 Words
    • 7 Pages

    Preliminary studies on the protease activity of the crude latex revealed that the enzyme resemble other plant proteases in their a) requirement of a reducing agent for maximal activity; b) Inhibition by several conventional agents such as PCMB; and c) presence of an active SH group. The pH and temperature activity curves and other stability studies suggest the possible presence of one proteolytic enzyme in the latex of Vallaris solanacea. Cysteine protease isolated from Vallaris solanacea was purified to homogeneity by ammonium sulphate precipitation (between 30-50% saturation) followed by DEAE cellulose ion-exchange…

    • 1502 Words
    • 7 Pages
    Great Essays
  • Improved Essays

    Grabosch et. al. introduced a dual click chemistry strategy for creating a biorepulsive background with the exposed mannose terminal SAMs (23). A polyethylene glycol linker having azide and amine terminal groups was used to support dual click reactions. Azides react with alkynes to form triazole ligation products and amines react with isothiocyanate to form thiourea bridges where the other ends of alkyne and isothiocyanate consist of thiol head group and terminal mannose, respectively.…

    • 1418 Words
    • 6 Pages
    Improved Essays
  • Improved Essays

    Experiment 7 Electrophilic Aromatic Substitution Of Salicyamide Name: Lidia Santiana Palha Student number: s3333523 Email-address: lidiapalha@gmail.com Name of demonstrator: H.Helbert Reaction Equation Summary Salicylamide and sodium iodide are dissolved in ethanol, and stirred and cooled to 0. After that household bleach was added while stirring vigorously, solution changed from colorless to pale yellow. Sodium thiosulphate and hydrochloric acid were added aswell. Product collected by vacuum filtration and recrystallized from 96% ethanol. IR- and H- NMR-spectrum were taken to determine the location of the I+.…

    • 960 Words
    • 4 Pages
    Improved Essays
  • Great Essays

    The experiment made use of two reactions in synthesizing 1-phenylazo-2-naphtol, also known as Sudan-1. The first is the diazotization reaction in which a diazonium salt is formed from the conversion of primary aromatic amines, such as aniline, to compounds with the nitroso functional group using a nitrous acid, such as HNO2. The diazonium salt was then used as an electrophile in a coupling reaction with an aromatic compound, β-naphthol. Recrystallization was conducted and yielded 0.18 g of a red-orange compound. The percent yield was determined to be 33.33%, based on the theoretical yield of 0.54g.…

    • 1448 Words
    • 6 Pages
    Great Essays