Valproic acid is considered more teratogenic with increased risks of congenital malformations and neurodevelopmental delays.24 Valproate exposure causes “fetal valproate syndrome” which comprises of facial clefts, cardiac defects, limb defects, hypospadias and abnormal facial appearance.28 Valproate is also associated with autism and the FDA has issued a warning stating that this medication should only be used under necessary circumstances.29
Lamotrigine is also teratogenic as it increases the risk of orofacial clefts in newborns.30 Children exposed to lamotrigine had better cognitive outcomes in comparison to those who were exposed to Valproic acid by the age of six years.31 Another case report of Lamotrigine during pregnancy highlighted
Lamotrigine is also teratogenic as it increases the risk of orofacial clefts in newborns.30 Children exposed to lamotrigine had better cognitive outcomes in comparison to those who were exposed to Valproic acid by the age of six years.31 Another case report of Lamotrigine during pregnancy highlighted