2-Methoxyphenol Synthesis

The development of simple methods for generating molecular complexity with defined stereochemistry from easily accessible starting materials became significant and fascinating over last few decades. A simple methoxyphenol is found to be most appropriate precursor for generating wide range of complex cyclic and acyclic architectures. Several chemical1-5 and electrochemical methods6 have been used for the umpolung of electron-rich nucleophilic 2-methoxyphenols and 4-methoxyphenols to electrophilic intermediates through oxidative dearomatization7 in presence of alcoholic solvents. These linearly conjugated cyclohexadienones generated from the oxidative dearomatization of 2-methoxyphenols in presence of alcoholic solvents by the aid of hypervalent iodine reagents8-14 are as known …show more content…
These highly reactive MOBs and MPBs intermediates undergoes numerous transformations such as cycloaddition reactions (ii) nucleophilic, electrophilic, and radical addition reactions, and (iii) photochemical reactions17. On account of their unique reactive features, rapid and easy generation they grabbed the attention of synthetic organic chemists. Synthesis of biaryl18,19 have received much attention in recent years because of their frequent occurrence in many natural products,20-22 pharmaceutically active compounds23-26 (Figure 18) and their wide applications in asymmetric synthesis,27-31 molecular catalysis 32-34 and material science35,36. In the past decades metal mediated