1-Naphthoylindoles

This thesis mainly focused on analysis approaches of twenty potential isomeric and designer drugs of 1-pentylacylindoles series of synthetic cannabinoids compounds associated mainly with naphthoylindoles and benzoylindoles structures, via using various analytical methods. These isomers and analogs represent potential designer modification of banned drugs and show the same elemental composition and yielding identical nominal, exact masses and general analytical properties which make the potential of misidentification increase. Electron- ionization gas chromatography- mass spectrometry (EI-GC-MS) technique was used as initial methods to differentiate and separate the target compounds. In addition, consecutive confirmation methods was provided by …show more content…
The 1-(1- and 2-naphthoyl)-3-n-pentylindole shows only two fragment ions at m/z 155 and the m/z 127. The JWH-018 shows one unique major fragment ion at m/z …show more content…
The six target compounds are subdivided into three groups based on their base peaks in the EI- mass spectra, each group have two compounds. First group shows the m/z 200 as the base peak including 2,3- and 2,5-dimethoxybenzoyl isomers. Second group shows the m/z 334 ion as the base peak including 2,4- and 2,6-dimethoxybenzoyl isomers. Third group shows the m/z 351 ion as the base peak for the 3,4- and 3,5-dimethoxybenzoyl isomers. The ortho-dimethoxy substituted isomers show unique fragment ions occurring at m/z 334 and m/z 200. Possible mechanism for the m/z 200 fragment ion is proposed and supportive analytical studies were carried out in this