Surfactant

solubility of docetaxel in various vehicles selected as oil, surfactant and co-surfactant for formulation of L-SNEDDS was determined and presented in the Table 1. Among the tested vehicles, Capmul PG8 NF (>250 mg/mL), Capmul MCM C8 (>250 mg/mL) and Transcutol P (>200 mg/mL) had the highest drug solubilization capacity for docetaxel. Whereas, Captex and Gelucire 44/14 shown the least solubility of docetaxel in them. Based on the solubility results, Capmul PG8 NF was selected as the oil phase, Cremophore EL as surfactant and Transcutol-P as co-surfactant. Capmul PG 8 NF (HLB 6) has partial aqueous solubility over Capmul MCM C8 which may help in easy dispersion of drug in an aqueous medium [34,35]. A good combination of surfactants with low and high hydrophilic lipophilic…

addition, detergents can include aromatic rings. Detergents can also be used as surfactants and foaming agents” ( Difference between Soap and Detergent - Is There Any? 2018 ). What are detergents made up of? All detergents are made up of 3 main sources. The main sources that go into detergents are, alkalies, surfactants and anti -redeposition agents, and catalytic enzymes to create these detergents. Alkalis are soluble salts and are a key point in making detergents. “Soluble salts of an alkali…

Benzalknoium salts are acknowledged as benzalknoium chloride, also known as BZK, BKC, BAC, alkyldimethylbenzylammonium chloride and ADBAC. These salts are known to have several names and are also considered as cationic surfactants. Surfactants are compounds that subordinate the surface tension among two liquids or among a liquid and a solid. Surfactants have the availability to act as detergents, wetting agents, emulsifiers, foaming agents, and dispersants. Benzalknoium salts are used in…

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What is silica gel New shoes, Pill bottles, Beef jerky, New purse, new backpacks. Silica gel is the little packages inside of products that were listed . Silica gel is to keep moisture out of those objects. Silica gel keeps the moisture from the product so it can stay dry. Silica gel can be in numerous places they can be even bought online. What does silica gel do Little packs of silica are(desiccant) means is a drying agent something that drys objects and absorbs the the…

2. Synthetic surfactants used in pharmaceuticals and their properties. 2.1 Classification of surface active agents. The widely used synthethic surfactants in pharmaceuticals are classifieds as according on their surface charges. 1.Anionic surfactants:sodium alkyl sulfonates .SDS,SLS. 2.Cationic surfactants:Quaternary ammonium chlorides (quats),pyridinium salts . 3.Zwetterionic (amphoteric) surfactants:phospholipids- Phosphatidylcholine (Lecithin). 4.Nonionic surfactants: spans( esters of…

symptoms. The progress of this breathing disorder may eventually lead to ventilator failure (Speer, 2011). Generally accepted view is that RDS is partially caused by inability of newborn`s lungs to produce a chemical substance, surfactant (Speer, 2011; Polin et al., 2014). Surfactant can be defined as a complex chemical substance consisting of proteins, lipids and glycoproteins. It serves to prevent alveolar collapsing by…

maximum drug loading into ME formulation, the oil, which showed higher solubilization capacity for sulpiride is selected for ME preparation. The choice of oil for ME is often a compromise between its solubilization potential for the drug and its ability to microemulsify. Results in table 1 represent the solubility of sulpiride into different oils, surfactants and co-surfactants. Non-polar solvents possessing low dielectric constants can dissolve non-polar solutes with similar internal pressures…

[40] However, for the formation of a nanoemulsion, high amount of energy is required, such as ultrasonification or high pressure homogenizer. Although both the systems are similar in physical appearance as they are transparent/translucent systems with low viscosity, there are differences in their stability due to the fabrication methods used. Since nanoemulsions are formed due to high input of energy, they are highly kinetically stable, but microemulsions possess high thermal stability. [40]…

enhances the permeation of the drugs through the skin because of the presence of surfactants. *They help in reaching the target site of action by various routes such as oral, parenteral,ocular ,nasal as well as topical routes such as transdermal drug delivery. *Niosomes are non toxic ,biodegradable, biocompatible and non-immunogenic. *Both hydrophilic and hydrophobic drugs can be incorporated in niosomal formulation . *Niosomes improve the therapeutic performance of the drug ,since the…