Substitution reactions

Examining Substitution Reactions of Several Alcohol-Containing Compounds Several Experiments were performed using substitutions reactions with hydrogen halides. These results and favor methods or pathways for the several alcohols were observed and will be discussed. Introduction for all the material Scheme 1. Substitution of 3-(m-tolyl)propan-1-ol to form 1-(3-bromopropyl )-3-methylbenzene. Aromatic materials used in this reaction has high boiling point thus the reaction was heated…

Intramolecular Friedel-Crafts Reaction” Researchers Ji-Young Min and Guncheol Kim from the Department of Chemistry at Chungnam National University developed a method of converting isoindoloisoquinolinones using a Friedel-Crafts reactions. Friedel-Crafts are reactions that involve a 2-step substitution mechanism where substituents are attached to aromatic rings. Two types of this reaction include alkylation and acylation. Alkylation involves the synthesis of alkylated products from reactions…

and started material. This suggests that the product made was Meta-Methyl nitrobenzoate even if it has little different melting point from the literature melting point which is 7880°C. Conclusion/Discussion: During the electrophilic aromatic substitution reaction between methyl benzoate and a nitrating solution of sulfuric and nitric acids, the Meta-Methyl nitrobenzoate product was obtained based on the product melting point range. Percent yield of the crude 56.42% and the percent yield of the…

In experiment 2, we observed that the reaction of halogenoalkanes with aqueous alkali and water which contains dissolved silver nitrate. Halogenoalkanes are alkanes which have one or more hydrogen atoms replaced by halogen atoms such as fluorine (F), chlorine (Cl), bromine (Br) and iodine (I) which are the elements in group 7 in periodic table. Halogenoalkanes have the general formula, RX, whereby R is an alkyl or substituted alkyl group and X is any of the halogen atom. Besides, halogenoalkanes…

DISCUSSION There are three chemical properties will be discussed which are combustion, reaction with bromine and reaction with potassium permanganate. Combustion was used to test the unsaturation of hydrocarbon. The degree of unsaturation refers to the number of the rings and / or multiple bonds present in the hydrocarbon molecule (McMurry, 2015). Hexane was a saturated hydrocarbon, it completely combusted and emitted carbon dioxide plus water. Cyclohexene was an unsaturated hydrocarbon, it…

According to R.A Aitken, “An asymmetric synthesis may be defined as a synthesis in which an achiral unit is an ensemble of substrate molecules is converted to a chiral unit such that the possible stereoisomers are formed in unequal amounts.” It relates to any synthetic process that incorporates one or more new elements of chirality during a functional group transformation. Asymmetric synthesis involves the formation of chiral molecules. An object is said to be chiral, if it cannot be…

More conjugated compounds absorb higher wavelengths/lower energies because as the wavelength increases the HOMO/LUMO gap (ΔE) decreases which is due to the compression of multiple molecular orbitals (ψ). According to Klein, the Ketchup stain (lycopene) on a shirt and upon application of bleach (NaClO), it breaks lycopene’s conjugation, therefore causing a decrease in conjugation; which directly correlates to the stain no longer being visible to the eye but when illuminating the shirt with…

DCE with PPh3 and I2 at room temperature for 19-24hr. These reactions proceeded in mild condition and gave 2x to 80-97% yield by column chromatography. Then, we attempted to apply the method of Friedel–Crafts acylation in order to synthesis of acylated oxazoles from 5-methoxy -2-phenyl oxazole (*). The normal conditions which used Lewis acid such as AlCl3 or TiCl4 with TFAA in DCE did not proceed the acylation, however, the reaction of introducing trifluoroacetyl group at the C4-position of…

This reaction can yield either a Markovnikov alcohol or an Anti-Markovnikov alcohol. If the reaction is carried out in acidic conditions, the reaction yields a Markovnikov alcohol. The mechanism includes the formation of a carbocation intermediate, which has a lower activation energy when it is formed on the more substituted or resonance stabilized carbon. The nucleophile then attaches to the positive charge created by the carbocation, yielding the Markovnikov product. However, if the reaction…

classified and checked for impurities by determination of IR and 1H NMR spectra. Results and Discussion For this lab, a nucleophilic acyl substitution reaction was carried out to synthesize acetanilide from aniline and acetic anhydride. In this reaction, the lone pair of electrons…