Sickle-cell disease

one time, Sickle Cell was seen as a great mutation. Soon, that great mutation became deadly. Being the first genetic disorder with a molecular basis that was known, Sickle Cell is the most common inherited blood disorder in the United States. Sickle Cell is more than just one disease. There are three types: trait, anemia, and the actual disease. Sickle Cell trait is present when only one gene of the disorder is inherited. In people with the trait, Hemoglobin S is heterozygous. Sickle Cell…

To what extent does Hydroxyurea work to treat Sickle Cell Anaemia? Problem: Suffering From Sickle Cell Anemia. Sickle cell anaemia is a severe hereditary disease when there is an inadequate amount of erythrocytes (red blood cells) or haemoglobin in the erythrocytes. Haemoglobin beta alongside alpha globin makes haemoglobin which contains 146 amino acids. Haemoglobin beta makes up 98% of the total haemoglobin, whilst alpha globin makes the remaining 2%. Haemoglobin beta protein is produced by…

Sickle cell anemia is an autosomal recessive inherited disorder that affects red blood cells. The sickle cell gene inherited form both parents causes the production of structurally abnormal hemoglobin, clinical known as hemoglobin S, which cluster together, causing red blood cells to become rigid and develop a crescent shape. These sickled cells become trapped in small blood vessel and block them, reducing blood and oxygen flow in many parts of the body, and leading to tissue and organ damage.…

Sickle cell anemia is an inherited disease in which the red blood cells have a deformed shape, which reduces their effectiveness to transport oxygen to the different parts of the body. Sickle cell anemia is predominantly present in people whose ancestors come from Africa. It is also common in people with Mediterranean, Middle Eastern and Indian Ancestry. The clinical diagnosis for sickle cell anemia is usually only evident in the patients who are heterozygous for the Hemoglobin S allele. The…

dreadful disease like sickle cell anemia. Sickle cell anemia is a chronic blood disorder in which a mutated form of hemoglobin causes the red blood cells to sickle. When the red blood cells sickle, they can cause clogging within small blood vessels. This can lead to severe pain, organ damage, and paralysis because the body does not get enough oxygen (Holtzchaw, Fred, Holtzclaw Theresa 108). Learning one’s genotype is important for the prevention of these diseases. As a carrier of the sickle…

body’s cells…

unrepaired in a cell, it is passed down to the offspring. However, most mutations result in recessive genes. Because humans are diploid, meaning that the individual has two sets of chromosomes from each parent, they are less likely to occur, acting as a safeguard against mutations. The offspring needs two mutated copies in order to have mutation, which is why they appear in the recessive gene more often than the homozygous dominant and heterozygous. This is the case with Sickle Cell Anemia,…

How Does Hydroxyurea Work To Treat Sickle Cell Anemia? Problem: Suffering From Sickle Cell Anemia. Sickle cell anaemia is a severe hereditary form of anaemia. Anemia is a condition where there is an inadequate amount of red blood cells or haemoglobin in the blood. HBB also known as haemoglobin beta or Beta globin is 146 amino acids long that makes up most of the haemoglobin in adult humans. HBB protein is produced by the gene HBB that is located in the multigene locus of β-globin locus on…

Homeostasis is the maintenance of a constant environment in an organism in response to internal and external stimuli. Organisms must maintain homeostasis to stay alive because stimuli can cause mild to severe effects. Cells require nutrients like oxygen, and a constant temperature. One disruption to homeostasis to homeostasis would be a lack of nutrients like oxygen by increasing the rate of respiration to increase oxygen to the body. Another disruption to homeostasis would be a change in…

we all had sickle cell trait and my daughter has SCD. According to Participant #5: I thought my husband did not have sickle cell trait until we had our son. I have SCD and I suffer from the complications; and I do not want my kids to have the same experience with this disease. Further, even though the Saudi community was not aware about blood marriage and inherited blood disease, some mothers with SCD tried hard to plan, before they got married, to marry to men who do not have Sickle Cell trait.…