Sensitivity and specificity

measure time and voltage; all other information available must be derived or inferred. Research over a number of years has established characteristic patterns and measurements associated with a variety of disease states. However, the sensitivity and specificity of these measurements vary with different pathologies impacting on the ECG’s diagnostic value. In other words, the ECG is useful in some situations such as detecting the presence of a myocardial infarction whilst of limited value in…

Experimental Design Aim 1: Determine the amino acid sensing specificity of folliculin. Since folliculin’s novel amino acid sensing function discovery, I plan to further understand whether FLCN specifically senses a certain amino acid and if this level of detection is enough to elicit an mTORC1 response. 1.1. Determine if folliculin’s novel molecular function in amino acid sensing is triggered by glutamine. mTORC1 activation by amino acids requires FLCN where its lysosomal residence during…

S gene) that are not detected by conventional diagnostic kits. But the result of DNA is similar to other cases of HBV, because they are usually positive for HBsAg. Overall, a prevalence of occult HBV infection depends on; geographical region, a sensitivity of HBsAg kits, HBV DNA amplification methods and co infections with…

Without a doubt, it is clear that a dual PET/CT scanner has greater sensitivity and specificity in accurately detecting malignant pulmonary nodules, than CT or PET alone. Gould, Fisher, Yi and Chang at al. confirm this finding through comparative studies that assess the efficacy of each imaging technique. Merging the individual qualities of both a PET and CT scan, allows for the combined advantage of identifying morphological features, anatomic location and metabolic activity of the tumor…

Several studies have been done to assess the diagnostic yield of these two techniques. Both techniques show high diagnostic accuracy, sensitivity and specificity for malignancy [15]. However, with development of individualized and targeted therapy of specific lung cancer histological subtypes, CT guided core needle biopsy technique has gained more ground as it avails more tissue both for histological…

Ethics in decision making Course: Clinical Practice Roles In this class, we discussed several ethical issues such as end-of-life decision making, advance directives, insurance reimbursement and interdisciplinary conflict. It is always hard to make decision when health care providers encounter ethical issues. There are several principles can guide us in our decision making. For example: Principle-Based Model is one of principle, which include autonomy, nonmaleficence, beneficence, justice,…

Annotated Bibliography on Acute Compartment Syndrome Via, A. G., Oliva, F., Spoliti, M., & Maffulli, N. (2015). Acute compartment syndrome. Muscles, ligaments and tendons journal, 5(1), 18. This journal is accredited by medical doctors through Muscles, ligaments and tendon journal, US National Library of Medicine and National Institute of Health. All medical physicians are in Italy. They specialize in traumatology and orthopedics. Various awards given for Orthopedic Research and all are…

individual Jurkat cells part time. Other studies with ChIPSeq-positive signals in transfection analysis were similar to a wide range of ChIPSeq signals with all except one being positive in each ChIPSeq conducted experiment. These results and the sensitivity results, showed NRSF interactome measurements to be genome-comprising and have been studied thoroughly enough to include more sites known than any prior experiment. The level of genome-wholeness is deducible to Solexa/Illumina sequencing…

Trend #1: Lateral Flow Immunoassay (LFI) Shan, S., Lai, W., Xiong, Y., Wei, H., and Xu, H. (2015) Novel Strategies To Enhance Lateral Flow Immunoassay Sensitivity for Detecting Foodborne Pathogens. Journal of Agricultural and Food Chemistry. 63, 745−753. DOI: 10.1021/jf5046415. This article talks about the simplicity, stability and sensitivity of conventional lateral flow immunoassay (LFI) device for the use of detecting foodborne pathogens. Foodborne pathogen has prevailed to cause disease…

The Gate Control and Specificity Theory were the two main descriptions relating to pain perception. Specificity was found much earlier, than Gate Control. Specificity revolves around the idea that every stimulus has a corresponding receptor. With the introduction of the cell theory, it determined that there are different sensory neurons for different stimuli. The pain fibers lead to a designated pain pathway. This was further researched and a new determination was made that the receptors must…