Randomization

proven case of symptomatic Lyme disease, or had positive serology findings of B. burgdorferi IgG or IgM antibodies. 280 of 281 patients underwent randomization into 3 drug groups, and all received at least one dose of ceftriaxone as part of the 2 week initial treatment regimen. Randomization by computer to accommodate for baseline characteristics. Randomization is good to minimize selection bia and make sure the groups are balanced for a more accurate measure of association between the effects…

To assess the bioequivalence by comparing the single oral dose bioavailability of test product MYCOCEPT 500mg (containing Mycophenolate mofetil 500 mg) film coated tablets manufactured by (confidential) with that of reference product CELLCEPT 500mg (containining Mycophenolate mofetil 500 mg) film coated tablets distributed by Roche Registration Limited, shire park, welwyn Garden City, AL7 1TW, UK in healthy, adult, human subjects under fasting conditions. 4.2. STUDY DESIGN A randomized,…

Randomization will be performed using a computer generated randomization allocation table by a computer technician not involved in the study. All participants will receive an opaque sealed envelope with the assigned randomization number and the instructions. The computerized random sampling method is appropriate because of its ease to use and accuracy of representation…

The major threat to internal validity is that the participants were not randomly assigned to groups. Without randomization, internal validity may be impacted by historical effects, maturation, testing effects, instrumentation, statistical regression, and selection bias. In this instance, treatment contamination needs to be considered. For instance, the control group…

Clearly, randomization is crucial to eliminate certain bias and have an accurate trial. 6. Explain how the intervention(s) in the treatment arm differed from how participants in the control arm were treated. In other words, what is the trial testing? Participants in the treatment arm were given 12.5 milligram Zinc Sulfate, whereas the participants in the control arm were given a placebo. The trial is testing whether Zinc Sulfate is beneficial to children who have Malaria or not. 7. Was the…

“distribute the idiosyncratic characteristics of participants over the treatment levels so that they do not selectively bias the outcome of the experiment” (Montgomery, 199, p. 24). Moreover, the error effects can also be reduced to minimal when randomization is implemented. The experimenters have done so by seating participants in different rows…

Evans, L., & Hardy, L. (2002) Injury Rehabilitation: A Goal- Setting Intervention Study, Research Quarterly for Exercise and Sport, 73:3, 310-319. Purpose: To examine both the use of psychological tools during injury rehabilitation and then to assess the effects of intervention on athletes undergoing therapy as well as their self-efficacy and self-perceptions. Method: Participants: 77 participants who have a sports related injury for longer than 5 weeks. These participants were found through a…

In the following experiment, a team of researchers tested the effectiveness of cognitive behavioral therapy on depression. They chose patients from three mental health centers across the country and assessed them with the MMPI-2-RF and the Beck Depression Inventory. Then, over a period of four months, followed their progress of recovery and reexamined them with the same tests. To determine whether cognitive-behavioral therapy had any effect, the patients were categorized to receive one of the…

1. Hand Washing The concept of hand washing is significant to public health as it support the prevention and control of infections. A large number of infectious diseases outbreak has been controlled by campaigns that focused on hand washing. The transmission of infections from person to person and objects to persons can be prevented through hand washing. Since the introduction of hand washing by Ignaz Philipp Semmelweis (1818-65) who documented the association between hand hygiene practices of…

intubation9,10. The aim of the present study is to compare the efficacy of awake tracheal intubation by GVL to FOB in morbidly obese patients with predicted difficult intubation scheduled for laparoscopic bariatric surgery. Methods Patient selection and randomization The study was approved from the human research committee (Security Force hospital, Riyadh, KSA) and written informed consent was obtained from all subjects prior to inclusion. Over one year, 64 patients undergoing laparoscopic…