Polymorphism

Genetically, they came to a similar conclusion as Pule in that BCL11A and MYB are large factors in the treatment of sickle cell. However, they also introduced a single nucleotide polymorphism on chromosome 11 that has an upstream effect on the production of the γ-globin gene. While they acknowledged the link between this SNP and the metabolism of arginine to nitric oxide, a vasodilator, and a transcription factor that induces DNA bending…

The high biological and clinic heterogeneity of the disease has fostered efforts to improve patients’ selection: choosing the right treatment for the right patient is the ultimate goal of all HR PCa research. During the last years, new tools became available, allowing for better selection and counseling of patients potentially curable with a single-modality primary treatment, but also useful to choose who is more likely to benefit from multimodality treatment, after a primary intervention. A…

The famous discussion of nature vs. nurture was somewhat interrupted by the realization that both aspects, genetics and environment, have important input in individuals. By combining the studies of genetics and psychology it is possible to correlate results from the fields and search for possible, and hopefully specific, genes involved in the expression of certain traits. For instance, Poulin et al (2011) explored the relationship between receptor genes of oxytocin and vasopressin and prediction…

work alone, other, cleverer animals, have decided to work together as teams instead of individuals. Within the packs of wolves, these small creatures have formulated strategy that organization that has allowed them to work effectively as a team. Polymorphism in leafcutter ants has enabled them to become efficient leaf collectors for the survival of their colony. The advanced utilities of fire ants has made possible the creation of living rafts for their fire ant community to live. The intuition…

The four forces of evolution are mutation, gene flow, genetic drift, and natural selection (Wwnorton). What I understand about mutation is that it is a random change that sometimes is good or bad. Whenever I hear the word mutation I automatically think of the X-Men because they were labeled as mutants and had random mutations happen to them. What I know about gene flow right now is that its when properties from one party flows to the other party that did not have that property. In my mind…

To the identification of several of the major loci and polymorphisms responsible. There is a high degree of variation in color, the amount and type of melanin pigment, and skin type (responsiveness to UV exposure) apparent between and within human populations. Though only those with European ancestry show a large…

Variability in effectiveness and side effects of certain medical interventions among patients is well accepted. Indeed most doctors would agree that a “cookie-cutter approach” to medicine is not best practice and a more concrete approach that offers some predictability about which patients are more or less likely to benefit from an intervention is favored. Precision medicine offers such an approach. Briefly precision medicine involves factoring in individual variability in genes, environment and…

Neuroadaptive impact of D9-tetrahydrocannabinol (THC) exposure and to executive functions in animals and Omethyltransferase (COMT) gene val158met polymorphism and the SLC6A4 gene 5-HTTLPR polymorphism has been linked to neurological impact. Researchers tested participants to see if polymorphisms moderate the harmful effects of cannabis use on executive function in young cannabis users. There were a total of 144 participants, 86 cannabis users and 58 non-drug user controls…

AETIOLOGY OF ALLERGIC RHINITIS Genetic predisposition Genetic predisposition is a major factor in the aetiology of AR. The clinical evidence include: the fact that a family history of allergic rhinitis is often present and the association of Allergic rhinitis with other atopic diseases that possess a genetic basis, such as allergic asthma or atopic dermatitis. It has been reported that Allergic Rhinitis has a hereditary component but does not exhibit a Mendelian hereditary pattern. The…

Introduction Has environment pressure of sunlight contributed to the variation in iris pigmentation? Only 10,000 years ago, someone who lived near the Black sea developed a mutation, which resulted in blue iris pigmentation (Eiberg, 2008). The iris consists of small connective tissue surrounded by muscular structure with a central opening known as the pupil (Sturm, 2008). This pupil allows the eye to control the amount of light, which enters to allow they eye to focus the lens to the retina.…