Liquid chromatography-mass spectrometry

The NMR sample was prepared by dissolving the collected product in chloroform-D (CDCl3) and DCM for mass spec. The 1H NMR spectra of the 2-bromo-4-methnoxy-phenol product reported significant peaks at (in ppm): δ = 3.02 (s, 2H), 3.75 (s, 4H), 6.97 (1H, dd), 6.81 (1H, dd,), 6.78 (1H, d), 5.15 (1H, s) 3.32 (m, 12H), 3.63 (d, 2H), 3.76 (s, 6H), 3.94 (m,…

Egypt The Egyptian outlook on perfumes could be derived from their lifestyle learned from the records, the objects found in connection to death and afterlife and mummified remains. The ancient Egyptians were concerned with the odours of everyday life and death. Dated to 1550 BCE, the Ebers papyrus gives us a wealth of knowledge on Egyptian medical preparations for ailments, perfumed anointing oils, and incense plants. As we move back through time, as early as the third millennium BCE, it…

What is Mandrax? Mandrax is an industry name of a synthetic barbiturate type drug that is made by combining a variety of chemicals which include Methaqualone, which is its active ingredient and which has sedative hypnotic properties and Diphenhydramine which is an antihistamine and also has sedative properties. Mandrax comes is a tablet form in a variety of colors such as; white, pink, purple, brown and green and is marked with the manufacturers symbol. Methaqualone was first synthesized in…

The purpose of my experiment is to examine the amount of BPA levels in food packaging for infants. I believe that the BPA levels in baby food varies considering food packaging size, texture, material, and color. To help me during my experimental process I have found several articles,that explain each concept of my experiment; also providing background information. Kubwabo, C., Kosarac, I., Stewart, B., Gauthier, B. R., Lalonde, K., & Lalonde, P. J. (2009). Migration of bisphenol A from plastic…

this experiment was to take the Gas Chromatography/ Mass Spectrum part of the “Analysis of US bills for cocaine using gas chromatography / mass spectrometry” lab and improve upon the gas chromatographic results. This would be done by finding a way to separate the peaks of cocaine and doxepin. The lab done previously showed the use of two different methods to obtain samples of cocaine and doxepin for spiked dollar bills. The two extraction methods were liquid-liquid extraction and solid phase…

A new, specific, rapid gas chromatography-mass spectrometry (GC-MS) method was described to identify and quantify pregabalin in human plasma. Silylation and acylation reaction were tried for derivatization of pregabalin before GC-MS analysis. Derivatization was achived using N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA). Identification and quantification of a new derivative were performed in selected ion monitoring mode using electron impact ionization. Pregabalin was…

successfully reverse engineered three different Henkel products and completed a competitive analysis of an equivalent product. Throughout the research process, I used many different analytical techniques including High Performance Liquid Chromatography and Gas chromatography–mass spectrometry to quantitatively and qualitatively define the components in the products, documenting the processes and results as the research was actively conducted. I am currently interested in developing my…

into contact and reacting with natural organic matter (Bougeard et al., 2010). With the amounts of hazardous chemicals being in such minute quantities, a reliable detection method is required. This can be achieved through the use of chromatography and mass spectrometry. Through these methods of detection chemical compounds can be isolated and identified while giving accurate…

in surface water, waste water treatment plants2 and in banknotes3. Different methods have been reported for cocaine detection; enzyme immunoassay3, 4, 5, 6 , gas chromatography (GC) and liquid chromatography (LC), capillary electrophoresis (CE), immunoassay, thermal desorption tandem mass spectrometry (TD-MS2) and ion-mobility spectrometry (IMS)3.…

2-n-butyl-4-chloro-1-[2- (1H-tetrazol-5 yl) biphenyl- 4-yl) methyl] imidazole-5- carboxyl acid)[1]. The determination of Losartan has been carried out in tablets by HPLC, capillary electrophoresis and super-critical fluid chromatography[2,3], in urine by gas chromatography- mass spectrometry[4] and, simultaneously with its active metabolite in biological fluids, by HPLC[5- 10]. Amlodipine Besylate (ADB) )[FIG.1.B], chemically,…