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Alongside CRISPR-Cas9 in site specific genome editing are ZFNs and TALENs. ZFNs are a DNA-binding motif assembled as ββα that utilizes a roughly thirty amino acid protein with DNA recognizing amino acids at the alpha helix (Gaj, Gersbach, & Barbas, 2013). These groups of amino acids usually recognize DNA in segments of three. This does not present much specificity in a genome. Therefore multiple DNA-binding motifs need to be combined to create specificity and result in highly specific…

Your Inner Fish by Neil Shubin Chapter Questions Chapter 1 – Finding Your Inner Fish 1. Explain why the author and his colleagues chose to focus on 375 million year old rocks in their search for fossils. Be sure to include the types of rocks and their location during their paleontology work in 2004. The author and his colleagues chose to focus on 375 Million Years as it was a period when the transformation took place from fish to fish with limb. The fish without characteristics of…