Fluorescent in situ hybridization

Abstract Chronic myelogenous leukemia also known as chronic granulocytic leukemia or CML, was the first cancer to be clearly linked to a genetic abnormality as the primary cause of oncogene formation. This bone marrow stem cell disorder is associated with a chromosomal translocation, which leads to the formation of an oncogenic protein. This translocation and oncogenic protein is then responsible for inhibiting DNA repair and the enhancing the susceptibility of further genetic abnormalities.…