Excipient

the brain and by blocking sensitization of pain receptors in inflamed tissues of the peripheral system (Pharmacology of Health Professionals, Bryant). Salicylates are the most commonly used of all analgesics and they are also combined with other excipients such as…

Solifenacin succinate immediate release tablets. The study involves preformulation studies of drug excipients, formulation and processing development along with evaluation of tablets made with the optimized formulation. Finally tablets were evaluated by in-vitro methods. 6.1. Drug excipient compatibility study Table 1. Results of compatibility study S.No. Name of Excipient Ratio of API/ Excipient Initial description Final Description 400C/75%RH Conclusion 2ndweek…

following things : 1.Medications are used to care disease or condition.2.Medication are given to treat a medical condition. A medication (a medicinal product) is ‘a product that contains a compound with proven biological effects, plus excipients or excipients only; it may also contain contaminants; the active compound is usually a drug or prodrug, but may be a cellular element’. ERROR : An error is ‘something incorrectly done through ignorance or inadvertence; a mistake, e.g. in calculation,…

Biopharmaceutics This is the in-vivo or in-vitro study of various physiochemical factors including developmental and design factors affecting the rate and extent of drug absorption with regards to the pharmacological effect of the drug. Biopharmaceutical studies use this result to improve likely problems that could arise from poor drug absorption and increase the bioavailability of newly formulated drugs. The main purpose of biopharmaceutical studies is to increase, monitor and maintain the rate…

solutions composed entirely of organic solvents. The combination of polyoxyethylated castor oil and ethanol that are water miscible surfactants and solvents can be used to solubilise the non-polar active ingredient, cyclosporine. Therefore, the excipients are appropriate for the formulation. Polyoxyethylated castor oil is a surface active agent that increases the solubility of drugs that are poorly soluble in water with the formation of micelles. Surfactants have an amphipathic nature, so it…

Direct Compression: Suitable for formulation with high drug loading yet good flowability. Excipients and API are first blended in a intermediate bulk container. The blend is then fed directly to the tablet press. Segregation is often the main issue that needs to be addressed, due to: – drastic differences in the characteristics of the ingredients…

pyridine ring may also act as a hydrogen bond acceptor, allowing the formation of co-crystal when it binds to the hydroxyl group of carboxylic acids. Fumaric acid (FUM) is a dicarboxylic acid that is safe to use orally, and it’s widely employed as an excipient in salt or co-crystal formation. FUM (Fig. 1b) can improve the solubility of several drugs through the formation of salt [13,14] and co-crystals [15–18]. Provision of mechanical energy such as grinding in a solid binary mixture with or…

The invention relates to formulation of Ketorolac Tromethamine and Phenylephrine Hydrochloride immediate release tablet having less disintegration time. HPLC method was developed and validated for determination of content of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. UV spectrophotometric method was developed and validated to study drug release profile of Ketorolac Tromethamine and Phenylephrine Hydrochloride in immediate release tablet. Background:…

ANALYTICAL METHODS Determination of λ max Gemifloxacin mesylate λ max is determined by preparing one standard concentration of 10μg/ml and scanning should be done. Preparation of 0.1N HCL 8 ml of hydrochloric acid is taken in 1000ml volumetric flask and dissolved with distilled water and then make up to 1000ml with distilled water. Standard graph of Gemifloxacin mesylate: The λmax of Gemifloxacin mesylate in 0.1N HCL was scanned in UV-Visible Spectrophotometer and found to have maximum…

R2 values of both the calibration plots were nearer to 1, which indicated that the methods developed were following Beer-Lambert’s law and could be used for further estimation. Analytical Interference Study of Raloxifene Hydrochloride with tablet excipients was done for assay and dissolution purposes, and no interference was observed at λmax of Raloxifene Hydrochloride. 10.1.2 Preformulation…