ROLE OF IMMUNOHISTOCHEMISTRY IN THE DIAGNOSIS OF SYNDROMIC GYNECOLOGICAL CANCERS Both ovarian and endometrial carcinomas can be expression of genetically inherited syndromes. Two main hereditary cancer syndromes are known that predispose to cancers occurring in the gynecological tract, namely Lynch and hereditary Breast and Ovary Cancer syndromes. Lynch syndrome is due to germline mutations in the MMR system, including MLH1, MSH2, MSH6 and PMS2 genes, and in EPCAM gene, that cause high…
For the purpose of this assignment, I researched an article titled, “The Role of DJ-1 in the Pathogenesis of Endometriosis” by Priyanka Rai and Sisinthy Shivajj. The article discusses many components in which are relevant to the disease, endometriosis. Endometriosis is a disease among women in which causes infertility and severe pelvic pain along with other health concerns. It is seen to occur within 10% of woman whom are of a reproductive or sexually-active age. It is due to the occurrence…
hypothalamus–pituitary axis, which results in compensatory increase in gonadotropin-releasing hormone (GnRH) and FSH and stimulates ovarian follicular development. The advantage of letrozole is that it avoids peripheral antiestrogenic effects on the endometrium while stimulating monofollicular growth.9 Letrozole (2.5–5 mg daily) or anastrozole (1 mg daily) is administered for 5 days and may be accompanied by FSH (at the normal doses for PCOS patients) and human chorionic gonadotropin (hCG;…
The most common serious infection among young women in the United States is pelvic inflammatory disease. There are one million new cases of pelvic inflammatory disease diagnosed each year. Pelvic inflammatory disease is a polymicrobial infection of the upper genital tract. Pelvic inflammatory disease is an infection of the uterus, fallopian tubes, or the ovaries. Pelvic inflammatory disease usually affects sexually active females in their childbearing years. “About one in every seven women…
“Since the legalization of abortion in 1973, there have been approximately 50 million abortions performed in the United States” (Pro-Life Action). An abortion is the process of terminating a fetus before birth. In the United States, obtaining an abortion was illegal starting in 1899 and was finally made legal in 1973 with the help of Roe V. Wade. Jane Roe was a codename for an organization called The Abortion Counseling Service of Women’s Liberation. This organization was made by a group of…
children born in 2000, if trends continue, will develop diabetes in their life” (source 2). In addition to that, according to the American Cancer society, studies have shown that one-third of cancers related to the colon, rectum, breast, liver, endometrium, esophagus, kidney, and pancreas are due to diabetes (source 1). And other studies tested that out of 20% of…
What is the contraceptive patch function? birth control patch hormones act through the skin through three mechanisms of action: - Avoid ovulation. - Generate changes in the endometrium to avoid the nesting of a possible fertilized egg. - Difficulty passing the sperm thickening the cervical mucus. The patch combines different hormones (estrogens and progestins) that are released into your body gradually to enter the bloodstream…
1. Explain the roles of hormones in sexual development. Hormones arouse cells and organs to specific activities and influence the way we look, feel, develop, and behave. 2. Describe the anatomy and physiology of the male and female reproductive systems. The visible part of the male sexual anatomy are the penis and the scrotum, the pouch that contains the testes. The testes makes testosterone and sperm. Immature sperm is stored in the epididymis. Inside the body are several structures involved…
There are many reproductive diseases that involve males and females. The types of reproductive diseases are epididymitis, orchitis, Prostatic Hypertrophy and Cancer, Testicular Cancer, Endometriosis, Pelvic Inflammatory Disease, and Ovarian Cancer. Epididymitis is an aggravation of the epididymis, more often than not brought about by a pathogenic living being, for example, gonococcus, streptococcus, or staphylococcus. Oftentimes happens with urinary tract or prostate contamination, mumps, or…
Case 2 A 32- year- old patient gravid 2 para1, under contraception. She was admitted for torrential vaginal bleeding 6 month after cesarean section. She had a history of postpartum hemorrhage and fever, 48 hours post cesarean of a fetal macrosomia. Also she has a history of curettage. At day 42 postpartum, 2 hours earlier her admission, she had a massive vaginal bleeding, dizziness and syncope. She was clinically stable. On gynecological examination, the vulva was bloody, blood clots within the…