Coagulation system

Deep vein thrombosis (DVT) is a condition where a blood clot forms in a deep vein, usually in the legs. The deep veins pass through the deep tissues of the legs. These veins transport blood from the legs and feet back to the heart. The superficial veins are located beneath the surface of the skin, and the deep veins run between muscles of the legs. Contractions of these muscles helps to squeeze the blood towards the heart when we move our legs. Deep vein thrombosis and pulmonary embolism are…

Hemophilia Hemophilia is a rare hereditary bleeding disorder where the blood cannot clot normally at the site of a wound or injury. Where someone who has a minor cut can profusely bleed, and it can get so bad that it could end up making them sick. There are two types of hemophilia, Type A and Type B. Type A: Is the most common type, it is caused by lacking Factor VII, which is one of the proteins to help blood form clots. Type B is caused by lacking Factor IX. Hemophilia is normally diagnosed…

Hematology is the study of blood and how it relates to health and disease (“Blood Disorders”). Hematologists study blood disorders, what causes them, and how to prevent, treat, and cure them (“Blood Basics”). Advances in this field have helped increase the quality of life in people who suffer from blood disorders. For example, CML (Chronic Myelogenous Leukemia) used to be treated with chemotherapy, which kills rapidly dividing cells, both healthy and diseased. Because of studies in hematology,…

Over three million people in the United States share the same anomaly, a bleeding irregularity named von Willebrand. Abbreviated as VWD, it is the most common inherited bleeding disorder. Erik von Willebrand, a Finnish scientist, first discovered VWD in the 1920s. This disease is a lifelong condition without a cure and can come with serious health hazards if not treated properly. For patients who have von Willebrand disorder, knowing the full definition, causes, classification, symptoms, tests,…

Hemophilia is a genetic disease that causes an affected person to severely bleed if cut. Lucky for hemophilia patients, gene therapy is an option. Gene therapy is a form of therapy during which selected healthy genes are transferred to an affected person’s cells. Not only is gene therapy a breakthrough in genetic engineering, but it can effectively cure genetic disorders such as cystic fibrosis and SCID and some acquired diseases like cancer. Gene therapy is carried out by packing a section of…

Hemophilia Hemophilia is a bleeding disorder in which blood doesn’t clot normally and results in excessive bleeding. The Jews were the first to recognize hemophilia and was described in the Talmud, which is a collection of Jewish writings, and stated that if two brothers had died after getting circumcised the next male baby from that family didn’t have to go through the procedure. Years later in 1803 a physician named Dr. John Conrad Otto in Philadelphia discovered that the disease was…

NITRO, W.Va. — On a rainy Friday afternoon, Dave Riley was inside the Nitro World War I Museum, eating lunch pizza, checking his phone and talking to a handful of residences. It was a day before he was supposed to deliver a keynote speech at an event honoring the city's Living Memorial Park. Nitro, which was founded during World War I, was holding the event has part of its dentinal celebration. Riley, who is from, Mobile, Alabama, was visiting the city to take part in its dedication of the…

factors become exhausted leading to thrombocytopenia. With a reduced amount of platelets and clotting factors in the blood, the body recognises it has overcompensated and begins to break down the already formed clots. Disseminating intravascular coagulation results, where widespread bleeding occurs internally and externally, effectively worsening hypotension, decreasing perfusion, and contributing to multiple organ failure (Manchanda, Gupta, & Bhalla,…

SIMULATION CROSS BETWEEN A HETEROZYGOUS FEMALE AND A HEMOPHILIA MALE BACKGROUND INFORMATION The survival of the human species throughout the last millions of years has been solely based on the randomized process of genetic inheritance from one generation to the next generation. Instead of duplicating their genetic information and create identical offspring, humans produce sex cells, through the process of meiosis, that carry only half of the genetic information, and fertilize them in order to…

The purpose of this paper is to summarize, assess, and synthesize eleven chapters across two primary texts listed as the required reading for the second week of POS 543. First, I’ll identify some of the central themes discussed across the readings. Second, I will assess the strengths and weaknesses of the various contributions to the literature on organizational theory relative to the major schools of thought. The required reading for week two offered a glimpse of the classic theories…