News is an essential part of American life, so much so its protection was included within the Bill of Rights. Not only is news media a means of transmitting information, it can strengthen a society, shape opinions, enrich one’s knowledge, and serves as a backbone of democracy by ensuring the public is apprised on topics of national concern. One such topic of concern within our society is the nation’s opioid epidemic. Lives are being lost at an alarming rate, state and local governments are…
Cold Bupivacaine Vs Magnesium Sulphate added to Room Temperature Bupivacaine in Sonar guided Femoral and Sciatic Nerve Block in Arthroscopic ACL Reconstruction Surgery Ashraf E Alzeftawy (MD) and Ahmad A El-Daba (MD) Assistant professor of Anesthesia and Surgical Intensive Care Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine,Tanta University. Abstract PURPOSE: The aim of this prospective randomised study was to compare the effect of cold bupivacaine 0.5% and…
Pain is modulated by descending mechanisms of nociceptive transmission between the brain and spinal cord. Multiple brain regions, pathways, and chemical mediators are involved in this modulation of pain. One type of powerful mediator involved in pain modulation are opioids. Endogenous opioid peptides, as well as exogenous opioid agonists, bind and activate opioid receptors. Activated opioid receptors directly inhibit ON cells and also inhibit GABAergic interneurons which inhibit OFF cells, thus…
reduce pain either by prescription or non-prescription medications. The first type of medication is non-narcotic analgesic drugs that can be bought over-the-counter without a prescription. According to Turley, (2014) aspirin (Bayer), acetaminophen (Tylenol), Aleve, Advil, and Motrin are just some of the medications available to treat symptoms of pain (p.427, 430, 432). Narcotic analgesic drugs require a prescription because there is a higher chance of addiction while treating symptoms…
Zohydro is an opioid analgesic hydrocodone that no contains acetaminophen is a 12-h extended-release formulation. Its approval was against the FDA’s expert panel recommendation. Opioids have been widely used as treatment for non-cancer chronic pain. However, it may be some misunderstanding in the efficacy and safety of this drugs because of their potential misuse, abuse and addiction. In the early 90s opioids were widely used because their few adverse effects and low abuse potential,…
CANNABINOIDS – TERPENES Cannabinoids CBG-A Formula: C22H32O4 Molecular Mass: 360.48708 g/mol LD50 (Lethal Dose): Unknown. May be similar to CBG, 300mg/kg for mice. (Compare to Nicotine for rats – 50mg/kg) Therapeutic Uses: Analgesic Antibacterial Anti-inflammatory Anti-proliferative (inhibits cancer cell growth) Cannabigerollic acid (CBGa) makes all other medicinal effects of cannabis possible. Through different types of biosynthesis it becomes THCa/THC, CBDa/CBD, CBCa/CBC and CBG. CBGa…
Good absorption after oral administration was obligatory for analgesic use. Therefore, we analyzed these derivatives according to the rule-of-five developed by Lipinski et al., (Table 3). The rule-of-five theoretically characterizes molecular properties for orally active drugs. The rule states that the 90% of orally…
Great post! I always learned a lot from reading your discussion. Opioid analgesics are usually a part of pharmacologic treatment for patients living with chronic pain. What do you think are the long-term benefits of using this particular medication for these patients? An opioid is a kind of analgesic medicine that relieves moderate to severe pain. It is very prevalent due to its effectiveness, and it has been used to manage acute to a chronic type of pain. However, treating chronic pain with…
Opiates are a common form of analgesics that is used as a temporary treatment for numerous acute pain disorders, such as patients suffering from trauma or those dealing with cancer. The use of opiates is now becoming disputable due to the fact that they are very addictive substances. Opiates are the most formidable and dependable analgesic agents (Howard 2011). It is also known that opiates have the ability to decrease anxiety and create mild sedation and a tangible sense of well-being. The use…
this experiment was to use the technique of thin layer chromatography (TLC) to identify the active analgesic ingredient of Advil and monitor the transesterification of methyl salicylate from acetylsalicylic acid. The synthesized methyl salicylate was then purified using acid-base chemistry and analyzed using H NMR spectroscopy. Identification of a proper mobile phase to separate common analgesics used in over-the-counter pain relievers was essential in being able to determine the active…