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77 Cards in this Set

  • Front
  • Back
(bacteria, virus, fungi) considered to cause granulomatous vasculitis of
____ have a preference for endothelial cells of capillaries, venules, arterioles (organism)
____ _____ typically cause inflammation of the vasa vasorum of the aorta
T. pallidum
(bacteria, virus, fungi) considered to cause granulomatous vasculitis of
____ have a preference for endothelial cells of capillaries, venules, arterioles (organism)
____ _____ typically cause inflammation of the vasa vasorum of the aorta
T. pallidum
for practical reasons the best way to class immune related vasculitis is one of 3 ways?
1. large vessel
2. medium sized vessel
3. small vessel
immune mediated vasculitis assoc. w/ "pulselessness"
Takayasu arteritis
Takayasu arteritis usually affects what portion of the vessels
aorta and major branches
Kawasaki dz AKA
Mucocutaneous lymph node syndrome (MCLNS)
what portion of the arteries does Kawasaki's dz affect
coronary aa.
which fungi vasculitises (2)are a common complication of pneumonia
necrotizing inflammation of medium or small aa?
2 examples of small vessel vasculitis
Henoch-Schonlein purpura
Drug induced vasculitis
How do you diff b/w PAN and polyangitis?
PAN- various stages of inflammation

Polyangitis- same stages of inflammation
PAN's destruction of vessel wall often leads to what BIG problem at what locations
microaneurysms at bifurcations
What Ig is Henoch-Schonlein purpura assoc. w/
IgA deposition on small vessel walls
p-ANCA +ive in what % of PAN
p-ANCA +ive in what % of Microscopic polyangitis (MPA)
T/F: MPA has segmental fibrinoid necrosis w/ granulomas
F: w/o granulomas
T/F: MPA is a selective dz of asian females?
F: can affect any gender, age, and ethnicity

***in US however --> typical pt is middle aged white male/female
Symptoms of MPA include: (5)
mnemonic: I'd rather Go SKiing With Naked Females than have MPA

Skin lesions
Weight loss
Nerve damage
some examples of skin lesions assoc w/ MPA
palpable purpura
nail splinters
urinary RBC casts assoc w/ what symptom of MPA
what 2 neuro signs assoc w/ mononeuritis multiplex in MPA
1. foot drop
2. wrist drop
what does the p and c in p-ANCA and c-ANCA stand for
p= perinuclear (myeloperoxidase MPO)

c= cytoplasmic (proteinase PR3)
combo Tx used in MPA
prednisone w/ cyclophosphamide (cytotoxic agent)
F/U Tx after control is estab'd
azathiprine (AZA) or MTX

prednisone dc'd
allergic granulomatosis (d/t asthma, rhinitis and eosinophilia) and angiitis assoc w/ medium and small sized glomeruli
which ANCA is assoc w/ Churg Struass and at what %

Necrotizing arteritis of respiratory tract and KIDNEYS assoc w/ "cresenteric GMNitis
Wegner's granulomatosis
Which ANCA is assoc w/ Wegner's and what %

Tx for Wegner's
intense vasospasm of small aa. and arterioles in young healthy women usually in response to cold or emotion
Raynaud's Dz
T/F: ulceration and gangrene are common problems w/ Raynaud's
F: rare problems
Raynaud's phenomenon is a 2ndary arterial insufficiency d/t arterial narrowing and can be induced by any of these 4 other dz's
1. SLE
2. Scleroderma
3. Atherosclerosis
4. Buerger's Dz
T/F: you must rule out RP in order to dx RD
_____ dz AKA thrombangitis obliterans
Age/gender/habit/ethnic assoc w/ Buerger's
20-35 yo male smokers

what sized aa. does Buerger's involve
medium and small
Angiogram findings used to Dx Buerger's
"corkscrew" appearance of aa.
T/F: Tx for Buerger's includes prednisone and cyclophosphamide
F: STOP smoking is the only Tx known to be effective -->those who keep smoking get amputations
Possible mechanism for Buerger's dz
autoimmune rxn to arsenic
Temporal arteritis or cranial arteritis AKA
Giant Cell arteritis
typical presentation of GCA
HA, facial (usually jaw)pain, vision probs
T/F: GCA is relatively uncommon and difficult to Dx
GCA Dx confirmed w/
Bx of temporal a.
In GCA does a negative Bx definitely rule it out? If not what do you do?
No, since GCA may not affect every portion of the temporal a.

get a repeat Bx
elevated/decreased ESR w/ GCA
very elevated
Drug Tx of GCA
prednisone w/ improvement w/in 1-3 days
irreversible outcome of GCA
Triad of aphthous oral ulcers, genital lesions, and recurrent eye inflammation
Behcet's dz
leading cause blindness of Japan
Behcet's dz is notorius for what type of vasculitides
nearly all types of aa. and vv. and all sizes
what organs does Behcet's like to hit?
eye, mouth, skin, lung, joint, brain, genetalia, GI

damn that's almost everything
HLA ____ assoc. w/ Behcet's
FHx responsible for what % of Behcet's
only 5%
What test is used to help Dx Behcet's dz
Pathergy test
Tx for Behcet's includes what usual combo
AZA, cyclosporine, cyclophosphamide, and chlorambucil
W/ organ or life threatening Behcet's dz what combo may be used
cyclophosphamide or chlorambucil and prednisone
what US banned drug can also be used to Tx mucocutaneous Behcet's
what are cryoglobulins
Ab's (immunoglobulins) that precipitate under cold conditions
what is the prime cause of the cryoglobulinemia
drug use
90% of cryoglobulinemic vasculitis cases are assoc w/ what type of IVDU infxn
T/F: Type I cryoglobulinemia is a polyclonal Ab that has rheumatoid factor activity
F: monoclonal w/ NO RF activity
What types of blood problems is Type I assoc w/
Lymphoma, Waldenstrom's macroglobulinemia and multiple myeloma (all monoclonal gammopathies)
T/F: In Type II cryoglobulinemia, the RF is monoclonal
T/F: In type III cryoglobulinemia, the RF is polyclonal
what class of dz's is type II cryoglobulinemia assoc w/
lymphoproliferative dz's
Can cryoglobulinemia be essential?
clinical presentation of most type II and III cryoglobulinemias (3)
1. vasculitis (usu LE purpura)
2. Glomerulonephritis
3. peripheral neuropathy
drug Tx for extensive cryoglobulinemia
cyclophosphamide and prednisone
T/F: cryoglobulinemia w/ sever hyperviscosity syndrome require plasmapheresis and chemo of underlying malignancy
What type of vasculitis pictured here
What type of vasculitis pictured here
angio finding assoc w/ what dz
what condition can this be found in