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35 Cards in this Set
- Front
- Back
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Corticosteroids are synthesized in the
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Adrenal Cortex
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What is the major gluccocorticoid
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cortisol
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What is the major mineralcorticoid
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aldosterone
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Under normal physiologic conditions 80% of cortisol is bound to
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CBG
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When are cortisol levels the highest
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early morning
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What are two factors that cause the hypothalamus to release CRH
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Diurnal rythm
Stress |
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Secretes CRH
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Hypothalamus
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Stimulates the anterior pituitary to produce ACTH
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CRH
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Stimulates the adrenal cortex to produce cortisol
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ACTH
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ACTH is released from the
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Anterior pituitary
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Cortisol increases what three things in the blood
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glucose
amino acids fatty acids |
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3 states that cause increased CBG levels
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pregnancy
hyperthyroidism estrogen therapy |
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What plasma protein do synthetic steroids preferentially bind to
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albumin
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What is cortisols mechanism of action
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regulates transcription of target genes
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What are cortisols catabolic effects
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Decreased muscle mass
Decreased Bone mass Decreased growth in children |
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What are cortisols effects on neutrophils
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Increase the number
Decrease ability to migrate from blood vessels |
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How do steroids reduce the expression of COX-2
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Reduces activation of phospholipase A2
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4 hormones inhibited by cortisol
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ACTH
LH GH TSH |
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Cortisols effect on blood
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increases RBCs
increases platelets |
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Intermediate acting steroid
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triamcinolone
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Long acting steroids
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betamethasone
dexasmethasone |
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Major synthetic mineralcorticoid
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fludrocortisone
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Weakness, fatigue, wt. loss, hyperpigmentation, hypotension, hypoglycemia during fasting
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Addison's disease
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Two meds used for Addison's disease
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hydrocortisone 20-30mg
fludrocortisone |
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Round face, truncal obesity, muscle wasting, poor healing, bruising, mental disorders, hypertension, diabetes
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Cushing's syndrome
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Chronic adrenocorticoid insufficiency
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Addison's disease
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Chronic excessive glucocorticoids
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Cushing's syndrome
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Hypertension, weakness, tetany due to renal K loss
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Hyperaldosteronism
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Detected by an increased ratio of plasma aldosterone to renin
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Secondary aldosteronism
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Tx of hyperaldosteronism
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spironalactone
epleronone |
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Steroid used most often to enhance fetal lung development
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betamethasone
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What kind of diet should a long term steroid therapy patient follow
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High K low Na
Low calorie high protein |
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Synthetic replacement of aldosterone
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fludocortisone
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Adrenocortical antagonists used ot inhibit steroid synthesis in Cushing's
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Metyrapone
aminoglutethimide ketoconazole mifepristone |
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Adrenocortical antagonist used in the tx of breast cancer
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aminoglutethemide
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