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8 Cards in this Set

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Function of warfarin (coumadin)?
To prevent thrombotic disorders or treat established thrombosis
VIP
What is the MOA of warfarin?
To depress the formation of factors 2 (prothrombin), 7, 9, and 10 by inhibiting the carboxylation of glutamic acid in these proteins that is essential for Ca binding.
VIP
What is the role of Vitamin K in the synthesis of coagulation factors 2, 7, 9, and 10? How does Warfarin act on these?
Factors 2, 7, 9, and 10 are all vitamin K dependant. Warfarin depresses the abilty to form these factors and thus it impairts blood coagulation in the extrinisic pathway.
Is aPTT or PT used to monitor anticoagulant effects of warfarin?
PT since it impairs the extrinsic pathway
What is the PT time prolongation value that is considered therapeutic in warfarin treatment?
1.5 time prolongation of PT time. Ex. Px with a baseline PT of 12 sec is therapeutic around 18 sec.
What is the formula for international normalized ratio (INR) and what is it used for?
INR = PT (sec) of patient / PT (sec) mean normal control

This value helps adjust the level of anticoagulant in a given px to optimize the dosage.
What are the theurapeutic uses of warfarin?
1. drug induced hypoprothrombinema
2. intestinal disorders and surgery
3. hypoprothrombinemias of newborn
Describe exactly what the role of Vit K is in synthesis of coagulation factors.
p.6 look up in Katzung