• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/64

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

64 Cards in this Set

  • Front
  • Back
_ drug acts on the hypothalamus
clomiphene +
_ drug acts on anterior pituitary
oral contraceptives -
_ drug acts on P-450 in women, thereby affecting _
ketoconazole -'s P-450

inhibiting:
--testosterone
--androstenedione
_ drugs inhibit testosterone from the testis (in the diagram in FA)
ketoconazole
spironolactone
_ inhibits aromatase
anastrazole
_ inhibits 5alpha-reductase
finasteride
_ drug inhibits androgen-receptor complex
flutamide
spironolactone
leuprolide mechanism
GnRH analog

agonist when pulsatile

antagonist when used continuously
a GnRH analog
leuprolide
leuprolide rx
infertility (pulsatile use)

prostate cancer
--continuous use
--use with flutamide

uterine fibroids
leuprolide

s/e
antiandrogen

nausea
vomiting
testosterone

two interesting clinical uses
anabolism to promote recovery after burn or injury

treat ER-positive breast cancer
testosterone s/e
inhibits release of LH
--> gonadal atrophy
--> reduces intratesticular testosterone

premature closure of epiphyseal plates

^ LDL
v HDL
antiandrogens include
finasteride
flutamide
ketoconazole
spironolactone
finasteride mechanism
5alpha-reductase inhibitor
finasteride rx
BPH

baldness
flutamide

moa
nonsteroidal competitive inhibitor of androgens at the testosterone receptor
flutamide rx
prostate carcinoma
ketoconazole moa
inhibits steroid synthesis
(inhibits desmolase)
spironolactone moa
inhibits steroid binding
_ antiandrogens are used to treat polycystic ovarian syndrome

to prevent _.

their side effects include _
ketoconazole
spironolactone

hirsutism

gynecomastia
amenorrhea
estrogens include
ethinyl estradiol
DES
mestranol
estrogens an interesting clinical use
use in men with androgen-dependent prostate cancer
estrogens s/e
^ risk of endometrial cancer

bleeding in postmenopausal women

^ risk of thrombi
estrogens contraindications
ER-receptive breast cancer

history of DVTs
estrogen partial agonists include
clomiphene

tamoxifen

raloxifene
estrogen partial agonists are aka
SERMs
SERMS are aka
estrogen partial agonists
clomiphene is a _
estrogen partial agonist
clomiphene moa
partial agonist at estrogen receptors
in hypothalamus

--prevents normal feedback inhibition

-- ^ release of LH and FSH from pituitary -->

stimulates ovulation
clomiphene rx
infertility
PCOS
clomiphene

s/e
hot flashes
ovarian enlargement
multiple simultaneous pregnancies
visual disturbances
tamoxifen

mechanism
estrogen antagonist on breast tissue
tamoxifen

use
treat ER-positive breast cancer
raloxifene

moa
estrogen agonist on bone

reduces resorption
raloxifene

rx
osteoporosis
^ estrogen --> what bone effects
v osteoclast activity
unopposed estrogen replacement therapy -->
^ risk of endometrial cancer
aromatase inhibitors
anastrozole
exemestane
anastrozole
exemestane

moa
aromatase inhibitors
anastrozole
exemestane

rx
postmenopausal women with breast cancer
progestins

moa
endometrium:

--reduce growth
-- ^ vascularization
progestins rx
oral contraceptives

endometrial cancer

uterine bleeding
mifepristone is aka
RU-486
RU-486 is aka
mifepristone
mifepristone

moa
competitive inhibitor of progestins
mifepristone

is given with _
misoprostol (PGE1)
misoprostol is a _
PGE1
mifepristone

s/e
heavy bleeding

nausea
vomiting
anorexia
abdominal pain
oral contraceptives

moa
prevent estrogen surge and LH surge

--> ovulation does not occur
advantages of oral contraception
v risk of endometrial and ovarian cancer

v incidence of ectopic pregnancy

v pelvic infections
oral contraception

sxs
depression
weight gain
nausea
hypertension
contraindications for oral contraception
smokers > 35 yrs old
(^ risk of cardiovascular events)

history of
--thromboembolism
--stroke
--estrogen-dependent tumor
oral contraception

lab findings
^ triglycerides
hypercoagulable state
a PGE2 analog used in obstetrics
dinoprostone
a PGE1 analog used in obstetrics
misoprostol
dinoprostone moa
PGE2 analog
dinoprostone

rx
it causes

cervical dilation
uterine contraction
labor
beta2 _ that have _ effect on the uterus include _
beta2 agonists

relax the uterus

ritodrine
terbutaline
ritodrine
terbutaline

moa
beta2 agonists

relax the uterus
tamsulosin moa
alpha-1 antagonist

selective for alpha 1A,D (found on prostate)

inhibits smooth muscle contraction
alpha receptors found on prostate: _
alpha 1A,D
vascular alpha receptors: _
alpha 1B
sildenafil
vardenafil

s/e
headache
impaired blue-green color vision

flushing

dyspepsia

risk of life-threatening hypotension in pts taking nitrates