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11 Cards in this Set
- Front
- Back
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What percentage of people who are depressed will respond to anti-depressants? What about if you give them placebo?
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67% for antidepressant
33% for placebo These statistics true for only first episode (multiple episodes: effectiveness of placebo goes to 0%) |
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How long is the standard of care with antidepressants following the first episode of depression?
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6 months to 1 year
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How long does an untreated episode of depression typically last?
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6 months or longer
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What are the various stages in the treatment of depression?
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Acute (6-12 weeks)
Continuation Phase (4-9 months) Maintenance Phase (>= 1year) Remission - No symptoms at all Relapse - appearance of symptoms of depression during the acute or continuation phases. Can occur before the patient has recovered fully from the index episode of depression. Recurrence - describes the onset of a new episode of depression, after the patient has been well for 6 to 12 months. |
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How long do the effects of MAOIs last?
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A single dose can last for 2 weeks. Therefore, be cautious of residual symptoms for up to 2 weeks after when taking a patient off of the drug.
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If you are going to an MAOI for the treatment of depression how long must you wait after the previous drug treatment before starting?
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2 weeks for arbitrary antidepressants and 5 weeks for Prozac
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How do Tricyclic anti depressants work (TCAs)?
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Block reuptake pumps for NE and 5HT (Aside: from Pharm what is another NE reuptake inhibitor that we learned about?.... Starts with a C... ends with an aine... And has a coke in the middle... Thats right... Cocaine!)
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SSRIs used for the treatment of depression inhibit a particular enzyme which may affect the levels of other drugs. What enzyme does it affect?
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P450s
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What are some neurotransmitters that affect sexual response?
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dopamine increase libido
Prolactine decrease libido Nitric Oxide and Acetylcholine increase arousal A decrease in 5HT can cause anorgasmia |
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What is SSRI withdrawal syndrome?
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Discontinuation syndrome
Less than 1% of patients Seen more frequently with Paxil and Venlafaxine Characterized by dizziness, parethesias, lethargy, nausea, feel as though electric shock is going through brain and spinal cord Onset usually within 5 days and can last up to 3 weeks Usually treat by restarting medictations and tapering off very slowly |
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Up to how many will have a response with electroconvulsive shock therapy for the treatment of Depression even after failing alternative treatments?
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80%
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