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8 Cards in this Set
- Front
- Back
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Describe the purpose and function of chlorpromazine (Thorazine)
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IM injection
Causes patients to become orthostatic Blocked dopamine at the D2 receptor |
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How many Dopamine Receptor types are there and what is the functioning of each type?
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There are 5. D1-D5
D1 and D5: Gs - stimulate cAMP D1 - deficits in spatial learning and consume less EtOH D5 - 10x higher affinity for dapamine than D1, don't know purpose D2, D3, and D4: Gi - inhibit cAMP D2 - develop bradykinesia (look parkinsonian) D3 - limbic areas (cognitive and emotinoal control) D4 - locomotr supersensitivity to EtOH, cocaine,a nd amphetamines |
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What are the various dopaminergic pathways and what are the associated symptoms
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mesolimbic tract (ventral temental area to limbic system) - Responsible for the positive symptoms of schizophrenia
Mesocortical tract (ventral tegmental area to frontal cortex) - responsible for the negative symptoms of schizophrenia due to a lack of dopamine Nigrostriatal tract (substantia nigra to acaudate nucleus) - extrapyramidal symptoms (EPS) - tremors and other things that resemble parkinsons |
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What is the functioning of Haldol?
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It is a anti dopaminergic drug.
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What do all atypical antipsychotics have in common?
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The are all blockades for 5HT2
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What is the atypical atypical antipsychotic and how does it function?
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Aripiprazole - partial agonist at the D2 receptor (only increases neurotransimission in cases of low dopamine state)
Antagonists at the 5HT2 receptor and partial agonist at the 5HT1A receptor |
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what are the extrapyramidal symptoms of antipsychotic side effects?
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Akathisia, Dystonia, Parkinsonian symptoms, Tardive Dyskinesia, Neuroleptic malignant syndrome
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All atypicals are approved for the treatment of the manic phase of what disorder?
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Bipolar
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