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8 Cards in this Set

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  • Back
Describe the purpose and function of chlorpromazine (Thorazine)
IM injection
Causes patients to become orthostatic
Blocked dopamine at the D2 receptor
How many Dopamine Receptor types are there and what is the functioning of each type?
There are 5. D1-D5
D1 and D5: Gs - stimulate cAMP
D1 - deficits in spatial learning and consume less EtOH
D5 - 10x higher affinity for dapamine than D1, don't know purpose
D2, D3, and D4: Gi - inhibit cAMP
D2 - develop bradykinesia (look parkinsonian)
D3 - limbic areas (cognitive and emotinoal control)
D4 - locomotr supersensitivity to EtOH, cocaine,a nd amphetamines
What are the various dopaminergic pathways and what are the associated symptoms
mesolimbic tract (ventral temental area to limbic system) - Responsible for the positive symptoms of schizophrenia
Mesocortical tract (ventral tegmental area to frontal cortex) - responsible for the negative symptoms of schizophrenia due to a lack of dopamine
Nigrostriatal tract (substantia nigra to acaudate nucleus) - extrapyramidal symptoms (EPS) - tremors and other things that resemble parkinsons
What is the functioning of Haldol?
It is a anti dopaminergic drug.
What do all atypical antipsychotics have in common?
The are all blockades for 5HT2
What is the atypical atypical antipsychotic and how does it function?
Aripiprazole - partial agonist at the D2 receptor (only increases neurotransimission in cases of low dopamine state)
Antagonists at the 5HT2 receptor and partial agonist at the 5HT1A receptor
what are the extrapyramidal symptoms of antipsychotic side effects?
Akathisia, Dystonia, Parkinsonian symptoms, Tardive Dyskinesia, Neuroleptic malignant syndrome
All atypicals are approved for the treatment of the manic phase of what disorder?
Bipolar