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12 Cards in this Set

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  • Back
What drugs have we learned for the treatment of bleeding?
Aminocaproic acid
Aprotinin
Protamine sulfate
Tranexamic acid
Vitamin K
What drugs have we learned about for the treatment of anemia?
Cyanocobalamin (B12)
Erythropoietin
Folic acid
Iron
What drugs have we learned about for the treatment of Sickle cell anemia?
Hydroxyurea
How does aminocaproic acid and tranexamic acid work?
They both inhibit plasminogen activation, are orally active, and excreted in the urine
How does protamine sulfate work?
Antagonizes the anticoagulant effects of heparin. Derived fromfish sperm or testes (Eww!) and is high in arginine content. It is postively charged and interacts with negative charged heparin to form a stable complex
How does vitamin K work?
Vitamin K is slow, requiring about 24 hours, but essentially completes the process for activating various factors through chemical reactions
How does Aprotinin work?
Stops bleeding by blocking plasmin and inhibits streptokinase
what is iron treatment used for?
To compensate for acute or chronic blood loss, insufficient intake during periods of accelerated growth in children, or in heavily menstruating or pregnant women.
IDA causes a hypochromic microcytic anemia.
What is Folic Acid used for.
Treat deficiency states arising from inadequate levels fo the vitamin. Causes may be:
increased demand (pregnancy, lactation)
Poor absorption caused by pathology in the SI
Alcoholism
Treatment with drugs that are dihydrofolate reductase inhibitors
What is Cyanocobalamin (vitamin B12) therapy used for?
Treatment of low dietary levels, or more commonly, poor absorption due to the failure of gastric parietal cells to produce intrinsic factor (pernicious anemia) or a loss of activity of the receptors in the intestine needed for uptake.
What is erythropoietin used for?
It is a glycoprotein, normally made by the kidney, that regulates red cell proliferation and differentiatino in the bone marrow. treatment for anemia caused by end stage renal disease, anemia associated with HIV-infected patients,a nd anemia in some cancer patients. may require co supplement with iron.
How does hydroxyurea treatment work for patients with sickle cell anemia?
It incrases HbF thus diluting abnormal HbS. Process takes several months. Polymerization of HbS is delayed in the treated patients so that painful crises are not caused.