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23 Cards in this Set

  • Front
  • Back
This FQ does not lose its greater gram negative coverage.
Levofloxacin
INhibits DNA gyrase and topoisomerase IV.
FQs

Resistance: efflux pumps and altered target site
This FQ is only PO, not IV
Gemifloxacin
Chelate in blood w/ metallic ions (di and tri) not mono
FQs (also tetracyclines, but not this lecture)
These 2 FQs do NOT tx UTIs
Gemifloxacin and moxifloxacin
Only 3rd gen FQ that has pseudomonal coverage
Levofloxacin
2nd gen FQ
Ciprofloxacin

covers Pseudomonal and atypicals
metabolized by CYP1A2
Ciprofloxacin
Tx of anerobes below the diaphragm except actinomyces
Metronidazole

pt complains of metallic taste
DOC for anthrax
Ciprofloxacin
UTI, MRSA, PCP prophylaxis, TOXO prophylaxi
TMP-SX

IV, PO
Steven johnson rash
TMP-SX (more the SX than the TMP)
inhibits conversion of PABA to dihydrofolic acid
Sulfonamides (sulfamethoxazole)
inhibits converstion of dihydrofolic acid to THF acid
Trimethoprim
TB drug that does NOT cause hepatotoxicity
Ethambutol

SE: decreased visual acuity and change in Red / green discrimination
inhibits mycolic acid synthesis
Isoniazid (IV and PO)
SE: hepatotoxicity, peripheral neuropathy
isoniazid (give B6 w/ this drug)
monotherapy for bacterial meningitis- combo therapy everywhere else
Rifampin (IV, PO)
SE: orange colored bodily fluids + hepatotoxicity
Rifampin
CYP450 Inducer that is used to tx TB
Rifampin
Only first line TB drug that is only PO
Pyrazinamide
hepatotoxicity + arthralgias
pyrazinamide
Second line TB
FQ (mox and levo)
Streptomycin- IV/IM
amikacin/ Ranamycin- IV/IM
Capreomycin- IV/IM
cycloserine-PO
ethionamide
P-aminsalicyclic acid