- Shuffle Toggle OnToggle Off
- Alphabetize Toggle OnToggle Off
- Front First Toggle OnToggle Off
- Both Sides Toggle OnToggle Off
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
3 Cards in this Set
Jaundice: Where do most of the bilirubin come from?
85% of daily production (0.2-0.3gm) from senescent RBC breakdown by macrophages in spleen, liver, and bone marrow.
The rest (15%) comes from:
turnover of hepatic heme,
hemoproteins (P450s etc.), or
premature destruction in bone marrow.
Differentiate between unconjugated and conjugated bilirubin.
- Exists as tightly-bound albumin complexes
- Cannot be excreted in urine
(even at high levels).
- A small amount of albumin-free unconjugated bilirubin exists in plasma (toxic to tissues)
Conjugated bilirubin (bilirubin glucoronides)
- Loosely bound to albumin.
- Can be freely excreted in urine
Jaudice is evident when plasma levels rise above 2.0-2.5mg/dL
(normal is 0.3 - 1.2mg/dL).
Jaudice occurs in
1) Excessive hepatic production of bilirubin,
2) reduced hepatocyte uptake,
3) impaired conjugation,
= High unconjugated bilirubin
4) decreased hepatocellular excretion,
5) impaired bile flow.
= High conjugated bilirubin