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28 Cards in this Set
- Front
- Back
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Th1 cells are involved in the generation of *** cells and *** reactions.
Th2 cells regulate responses by *** and ***. |
Tc - DTH
mast cells and eosinophils |
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CAMS work with what types of cells?
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leukocytes, monocytes, or granulocytes
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Cytokines involved in Th cell differentiation..
***/*** cells produce *** *** cells produce *** |
macrophages/dendritic produce IL-12
mast cells produce IL-4 |
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Hypersensitivity - IgE induces ***.
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mast cell degranulation
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Type 1 TI antigens...
Type 2 TI antigens... |
LPS
Repetitious polymeric proteins |
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The most important cytokines in determining Th1 development is *** and ***.
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IL-12
IFNγ |
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The most important cytokines in determining Th2 development is *** and ***.
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IL-4
IL-5 |
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IL-4 and IL-13 are type I hypersensitivity mediators that...
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Increase IgE production.
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Cytokine *** induces proliferation and differentiation of *** cells into CTLs.
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IL2
CTL-P |
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*** promote transformation into a plasma cell.
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IL-4
IL-5 |
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*** increases plasma cell antibody production.
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IL-6
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Interaction between TCR *** to BCR *** stimulates transformation to *** B-cell.
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CD154
CD40 memory |
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Antigen filtering through the lymph node *** percolates through the ***. It is captured by ***.
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cortex
follicles macrophages |
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After activation T-cells divide ***/day for *** days.
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2-3 times a day
4-5 days |
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Superantigens can activate V*** because they *** the TCR antigenic cleft.
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β
bind outside |
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CD4 and CD8 T-cells enter circulation as *** cells. CD4 cells are *** CD8 cells.
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resting
twice |
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As T-cells enter the thymus they first develop ***, ***, and *** in their cell membrane. They become *** then either *** or ***.
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c-kit
CD44 CD25 Double postitive CD4+ or CD8+ |
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T-cell activation Signal 1 -
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antigenic peptide w/TCR-CD3 complex
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T-cell activation Signal 2 -
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interaction between TCR CD28 and APC B7 family-proteins
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Superantigen proteins bind *** domain of ***. They also bind to *** of ***.
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Vβ domain of TCR
α-chain of MHC II |
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*** T-cells have a regulatory role of inhibiting other T-cells.(cytokine-cytokine)
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CD4-CD25
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In Type I hypersensitivity plasma cells secrete ***. This binds to *** receptors on mast-cells and ***.
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IgE
Fc basophils |
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Developing T-cells are known as ***.
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thymocytes
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APC have... to Tc/Th
APC-LFA-3 to *** APC-ICAM-1 to *** APC-CD22 to *** |
CD2
LFA-1 CD45R |
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Tc and Th have...
TCR-CD2 to *** TCR-LFA-1 to *** TCR-CD45R to *** |
LFA-3
ICAM-1 CD22 |
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What do prostaglandins do?
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vasodilation
contraction of pulmonary smooth muscles platelet aggregation |
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What do activated H1 receptors cause?
1) 2) 3) |
1) Contraction of intestinal/bronchial smooth
muscles 2) Increased permeability of venules 3) Increased mucus secretion by goblet cells |
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What do activated H2 receptors cause?
1) 2) |
1) Increases vasopermeability and vasodilation
2) Stimulates acid secretion in the stomach |
