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11 Cards in this Set

  • Front
  • Back
Interleukin 1(IL-1)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. innate immunity
2. monocytes, macrophages, endothelial c., epithelial c.
3. vasculature(inflammation), hypothalamus(fever), liver(acute phase proteins)
Tumor necrosis factor-α(TNF-α)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. innate immunity
2. macrophages
3. vasculature(inflammation), liver(acute phase proteins), loss of body muscle/fat, neutrophil activation, cell apoptosis
Interleukin 12(IL-12)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. innate immunity
2. macrophages, dendritic c.
3. NK cells
4. influences adaptive immunity (increases B-cells and their secretions)
Interleukin 6(IL-6)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. innate immunity
2. macrophages, endothelial c.
3. liver(acute phase proteins), influences adaptive immunity (increases B-cells and their secretions)
Interferon α(INF-α)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. innate immunity
2. macrophages
4. activates NK c., induces antiviral state, increases MHC I
Interferon β(INF-β)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. innate immunity
2. fibroblasts
3. activates NK c., induces antiviral state, increases MHC I
Interleukin 2(IL-2)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. adaptive immunity
2. T cells
3. increases T-cells, B-cells, & NK cells, activates NK c.
Interleukin 4(IL-4)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. adaptive immunity
2. Th2 cells, mast cells
3. TH2 cell differentiation, isotope switch to IgE
Interleukin 5(IL-5)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. adaptive immunity
2. Th2 cells
3. Eosinophil activation and generation
Transforming growth factor β(TGF-β)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. adaptive immunity
2. T cells, macrophages, other cell types
3. Inhibits all T-cell activity, B-cell prolif., inhibits macrophages, isotope switch to IgA
Interferon γ(INF-γ)
1. Type of Immunity
2. Secreted by...
3. Target
4. Effect
1. adaptive immunity
2. Th1, CD8+, NK
3. activates macrophages, increases MHC I, MHC II, and antigen presentation