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46 Cards in this Set

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  • Back
Primary lymphoid organs do this...
provide environment for development and maturation of lymphocytes
Secondary lymphoid organs do this...
trap antigens from nearby tissues
mature lymphocytes interact w/antigens
Leukocytes are *** that ***.
various white blood cells
participate in immune response
Greek leuco...
white
All blood cells derive from ***.
HSC
hematopoitic stem cells
WBC and RBC first develop in the *** during ***... and then the *** for ***
yolk sac - first weeks
live and spleen - 3rd to 7th months
Later in life the WBC and RBC develop in the *** for... and then *** for....
long bones - 4 mo to 25 yrs
cranium, pelvis, sternum, rubs, vertebrae - 4mo thru death
Self renewing HSC cells give rise to *** and *** progenitors.
lymphoid
myeloid
Three types of blood cells... and amount per mm^3...
red blood cells - 5X10^6
platelets - 3X10^5
leukocytes - 7X10^3
Name a few transcription factors essential for hematopoietic lineages and their
GATA-1 - erythroid
GATA-2 - erythroid, myeloid, lymphoid
Name the lymphocyte cells.
NK cells
B cells
T cells
L. erythros
red
L. kytos
hollow
*** are immunoregulatory hormones.
cytokines
*** cells include fat cells, endotherlial cells, fibroblasts, and macrophages.
Stomal
B cells ***....
T cells ***...
antigen generators
attack and kill
Red blood calls are also called ***.
erythroids
Lymphocytes make up **% of WBCs and **% of the lymph.
20-40%
99%
There are approx. *** lymphocytes in the body.
10^12
What lymphocytes are adaptive and what are innate?
B and T - adaptive
NK - innate
Lymphoblasts differentiate into *** or *** cells.
memory
effector
*** cells are the anti-body secreting effector cells of the B-cell lineages. They have abundant *** and ***.
Plasma
concentric layers of ER
and
golgi vesticles
T cells w/CD4 function as ***.
T cells w/CD8 function as ***.
Th
Tc
CD4 stands for....
cluster of differentiation molecule 4
There are about *** immunoglobulin molecules on each B-cell surface.
2x10^5
MHC stands for... and is a ***...
major histocompatibility complex
MHC I are expressed by ***.
all nucleated cells
MHC II are expressed by ***.
a few specialised antigen presenting cells
dendritic, macrophages, B-cells
*** are large granular lymphocytes.
Natural Killer cells
MNP stands for ***.
mononuclear phagocytes
MNP in blood are called ***.
MNP in tissues are called ***.
monocytes
macrophages
Monocytes circulate in blood for 8 hours before ***.
migrating to specific tissues
Phagolysosome are ***.
a fusion of a lysosome and a phagosome.
In monocytes phagocytosis is followed by ***.
digestion and presentation of antigen
PMN stands for ***.
polymorphonuclear leukocytes
*** provide defense against parasites.
Eosinophils
*** play a major role in allergic responses.
Basophils
Name two primary lymphoid organs.
thymus
bone marrow
Name three secondary lymphoid organs.
lymph nodes
spleen
various mucosa-associated lymphoid tissues(MALT)
Lymph returns to circulatory system via *** and ***.
venules
primary lymphatic vessels
The *** duct empties lymph into the *** vein.
thoracic duct
left subclavian vein
The first organized lymphoid structure to encounter antigens are ***.
lymph nodes
The three regions of lymph nodes are ***.
medulla
paracortex
cortex
The *** of the lymph node is populated by lymphoid lineage cells.
medulla
The *** of the lymph node is populated by T- cell and dendritic cells.
paracortex
The *** of the lymph node is populated by lymphocytes(mostly B), macrophages, and follicular dendritic cells.
cortex