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27 Cards in this Set

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What are the traditional preservatives for blood?
CPD, CP2B, this allows 21 day of RBC/Whole blood storage..

CPDA-1 allows for 35 days of rbc/whole blodo storage
What are the additive solutions?
Increases shelflfe to 42 days, add to CPD, CP2D after plasma is removed. (within 72 hours), increases shelf life to 42 days

What are the common types?
AS-1
As-3
AS-5
What are the contents of whole blood?
500mL
rbc's, 10^9 wbc, platelets, anticoagulant (63ml)
When would you do this? What are contraindications?
neonates, some autologous, and rapid hemorrhage...
anything that is more specific would be better?
What kind of storage time, conditions?
1-6C, length depends on anticoagulant
How long can frozen rbc's last?
10 years at -65C, 24 hours after thaw
Washed rbc's? How long?
24 hours 1-6 C
platelets? How long?
5 days 20-24C
WBC How long?
20-24 hours (20-24C)
FFP(how long)
1 year, -18C, 24 hours at 1-6 C after thaw
Cryo (how long)
1 year at 18 C, 6 hours at 20-24 C
How are PRBC's made?
Made from whole blood by removing the plasma?
What is the volume, contents?
250mL, 350mL with additive
rbc (200mL), plasma 50mmL, wbc's 10^8, and platelets, anticoagulant, additive solution, 200mg of iron
What are the indictations?
need increased o2 capacity.
acute or chronic hemorrhage (over 20% of blood volume acutely), hemolysis, and marrow failure.

consider for hemoglobin between 7 and 10 and signfificant cardiopulmonary disease.
What are contraindications?
Acute hemorrhage that is less than 20% of the blood volume, crystalloids.
What are contraindications for prbc?
usually over 30, nutritional anemia
How long can prbc transfusion take for expected effect?
up to 24 24 hours?
What is the storage for prbc?
Same for whole blood with cpd, cpda-1.
What are compatable fluids? with prbc
saline, abo compatable plasma, albumin.

contraindictation, LR, 0.45, abx, other drugs, tpn
What are the contents of PC?
5.5x10^10 in 90%.. plasma (including 80mg of fibrinogen), WBC's, 10^7
When do you transfuse platelets?
10K, 20K if febrile of septic, 50K if bleeding or major surgery, no prophylactic transfusion

thrombocytopathy
congenital defects, drugs, external agents, cardiac bypass machine, ecmo

metabolic effects
What are contraindications to platelet transfusion?
ttp (abdolute), HIT (type II) (near absolute), ITP (relative)
What is the dose of you give in infants?
usually 1 unit per 10 kg of body weight.. typcially 6-10 at a time in adults.. 10-15mL of kg in neonates
What are the expected effects?
5-10K per page?, one hour post count
What antigens are present on platelets?
ABO but not Rh antigens are present on platelets. May have some RH contaminatsion.
When/how shoudl you do platelets transfusion?
Rh prophylaxis with Rh incompatability (1 vial RhIG per 30 units RH+ PC; 1 per 3 Rh+ apheresis units)
What's the difference between major and minor transfusion reaction?
Major: platelet abo antigens incompatable with recipient plasma (like a plts to o recip)

minor its the donor abo antibiodies incompatable with recipeient rbc's..

(reverse hemolytic transfusion reaction)