X_Exam1 Mfm2_23

Front 1

what are the 4 barrier types discussed in class:
1.
2.
3.
4.

Back 1

1. blood-brain barrier
2. renal tubules
3. hepatic blood vessels
4. blood capillaries and renal glomerular membranes

Front 2

what is significant about the blood brain barrier:
1.
2.

Back 2

1. very tight junctions
2. efflux mechanisms

Front 3

what does the following describe:

movement of moleucles across the cell membrane via special transport proteins that are embedded within the cellular membrane

Back 3

carrier mediated transport or facilitated diffusion

Front 4

identify the two types of diffusion depicted in the image:

Back 4

(see figure)

Front 5

what is the is the gene for the efflux transporter discussed in class and what is the name of the transporter:

Back 5

gene: MDR1
efflux transporter: P-glycoprotein (P-gp)

Front 6

... discovered by its ability to confer resistance to chemotherapy

Back 6

P-glycoprotein

Front 7

Actively excretes substrates into bile and urine

Back 7

P-glycoprotein

Front 8

Minimizes xenobiotic penetration in the gut and brain

Back 8

P-glycoprotein

Front 9

what are the important main sites of localization of P-glycoprotein in the body:
1.
2.
3.
4.
5.

Back 9

1. brain
2. apical part of intestinal cell
3. tumor
4. lymphocyte
5. hepatocyte

Front 10

what is the function of CYP3A4 in the gut epithelium

Back 10

metabolizes drugs

Front 11

what is the affect of grapefruit juice on pharmacokinetics of various drugs:

Back 11

1. possibly inactivates cytochrome P450 3A4
2. possibly inhibits function of P-glycoprotein

Front 12

place…It is recommended to avoid the consumption of grapefruit juice in transplant recipients treated with ...

Back 12

tacrolimus

Front 13

cyclosporin A may have inhibited cytochrome ...

Back 13

P450 3A4 enzyme (CYP3A4)

Front 14

inhibition of P-Glycoprotein–mediated drug transprot by ... may explain the interaction between ... and ... and why ... concentration rises

Back 14

quinidine
digoxin
quinidine
digoxin