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31 Cards in this Set

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  • Back
Cytoskeleton generates force by two different mechanisms:
1.
2.
1. Assembly/disassembly of cytoskeletal polymers
2. Cytoskeletal motor proteins
motor proteins have ... and ... domains
head
tail
head is ATPase site where ... is hydrolyzed to ... and ...
ATP
ADP
Pi
head domain binds to either ... filaments or ...
actin
microtubules
Movement of motor proteins is (multi-/uni-) directional
uni-
... is involved with actin filament based motility and is (plus/minus) -end directed
myosin
plus
... is involved with microtubule based motility and is plus-end directed
kinesins
... is involved with microtubule based motility and is minus-end directed
dyneins
myosin ... and ... are the most abundant types of myosin in the body
I
II
myosin ... consists of one head and a short tail
participate in endocytosis,
found in microvilli and links ... laterally to the plasma membrane
I
actin filaments
myosin ... has two heads and a coiled-coil tail and does:
1.
2.
3.
II
1. muscle contraction
2. cytokinesis
3. cell crawling
kinesins are microtubules that transport ...
cargo including organelles and chromosomes
kinesins are important in separation of ... along the
metaphase plate
mitotic chromosomes
dynein composed of two heavy chains that correspond to the
...
heads
... move cargo along microtubules toward the minus ends
dynein
... important in movement of chromosomes towards mitotic spindle
dynein
the following describes ... :
Cyclic attachment/detachment coupled to ATP hydrolysis and conformational change
-both heads move processively down microtubule toward plus end
-two heads, each with reciprocal affinity for nucleotide (ATP or ADP) and microtubule
kinesin walking
the following describes what what kind of cell motility:
Whole cell movement (crawling)
Phagocytosis
Cytokinesis
Contraction
Actin filament-myosin based motility
the following describes what kind of cell motility:
Ciliary and flagellar motility
Cytoplasmic membranous organelles
Movement of chromosomes
Microtubule-motor protein based motility
Antegrade-movement of membrane-bound particles toward the ... of a cell
periphery
Retrograde-movement of membrane-bound particles toward the ... of a cell
center
kinesin transports cargo to the (plus/minus) end and dynein transports cargo to the (plus/minus) end
plus
minus
... pulls ER to periphery of cell and ... pulls golgi apparatus to center of cell
kinesin
dynein
cilia and flagella movement are ... based and whole cell movement (crawling) is ... based
microtubule
actin filament
... primary function is to move fluid over the surface of a cell and propagate regular waves along their length
cilia
flagella
flagella are found only on ...
sperm
central microtubule complex of eukaryotic cilia and flagella with the characteristic 9 + 2 arrangement of tubules is called ...
axoneme
in axonemes there are two rows of ... ‘arms’ found on the outer doublet microtubules that generate the ... motion
dynein
sliding
Kartagener’s Sydrome (Immobile Cilia Syndrome) defect in the ... of the axoneme patients suffer from:
1.
2.
dynein arms
1. ineffective mucocilliary clearance
2. immotile spermatozoa
movement of cell towards a positive signal is known as ...
chemotaxis
cell crawling/migration is based on the coordination of 3 events:
1.
2.
3.
1. extension of leading edge driven by actin polymerization
2. adherence to substrate
3. contraction of rear of cell - myosin pulls on actin filaments attached to focal contacts