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51 Cards in this Set

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what do alpha adrenoceptors generally mediate?

exception?
excitation of organ systems

exception: intestine motility decreased
what do beta adrenoceptors generally mediate?

exception?
inhibition

exception: the heart
adrenergic receptors that mediate classic sympathetic reactions at end organs
alpah-1
Where are alpha-2 adrenoceptors?
presynaptic SNS neurons

(some postsynaptic SNS effectors)
Where are beta-1 adrenoreceptors?
heart (classic)
adipocytes
Where are beta-2 adrenoceptors?
smooth muscle and most other sites
Where are beta-3 adrenoceptors?
adipocytes
Alpha-1 signal transduction pathway?
Gq--> PLC --> IP3 --> PKC --> Ca
Alpha-2 signal transduction pathway?
Gi --> inhibit adenylyl cyclase
Beta-1 and -2 signal transduction pathways?
Gs --> stimulate adenylyl cyclase
The catecholamines of the ANS.
Epi, NE, and isoproterenol
rank the order of potency of catecholamines for alpha adrenoceptors
Epi > NE >> Iso
order of potency of catecholamines for beta-1 adrenoceptor
Iso > Epi = NE
order of potency of catecholamines for beta-2 adrenoceptor
Iso >= Epi >> NE
an almost pure beta adrenergic agonist
Iso
Catacholamine:
powerful alpha agonist that stimulates beta-1 adrenoceptors (but not so much beta-2)
NE
Catecholamine:
relatively high affinity for all adrenoceptors
Epi
NE effect on Heart rate?
decrease


b/c BP goes high, and reflex bradycardia kicks in
NE effect on peripheral resistance?
increase
NE effect on BP?
increase
Epi effect on peripheral resistance?
high dose = increase


low/moderate dose = decrease
BP change after Epi injection?
No appreciable change
Heart rate change after Epi injection?
increase
Iso is a _____-agonist
beta
Peripheral resistance change with Iso injection
decrease
BP change with Iso injection
decrease
Heart rate change with Iso injection?
increase
alpha-blocker effect on peripheral resistance
decrease PR
alpha blocker effect on BP
decrease BP
alpha blocker effect on pulse rate?
increase (not much)
alpha-blocker + Epi effect on peripheral resistance?
decrease (alot)
alpha-blocker + Epi effect on BP?
decrease
alpha-blocker + Epi effect on heart rate?
increase
alpha-blocker + NE effect on peripheral resistance?
no appreciable change
alpha-blocker + NE effect on BP?
no appreciable increase
alpha-blocker + NE effect on heart rate?
increase
What is the website with NE, Epi, Iso games?
www.kumc.edu/research/
medicine/pharmacology/
CAI/webCAl/as71.htm
bronchial smooth muscle has ________adrenoceptors
beta-2
when treating bronchial conditions, be careful with nonselective beta ________
agonists
beta-2 agonists delay premature ______
labor

(relax uterine smooth muscle)
beta agonists relax detrusor muscle while alpha agonist contract ________
sphincther
alpha and beta stimulation effects on GI muscle
relax GI muscle,
reduce motility,
may contract sphincters
alpha simulation affects what muscle to cause mydriasis
contracts radial muscle
why do catecholamines have a limited effect on the CNS
does not cross BBB well
Why use Epi mixed with local anesthetics?
to decrease local bleeding by vasoconstriction and later, prevent extreme swelling
catecholamines that are powerful cardiac stimulants
Epi / Iso
Catecholamines for hypotensive crisis / shock
NE
why are catecholamines not effective orally
rapid conjucagion in GI tract

MAO and COMT in the liver
preferred injection method of catecholamines
IV
Side effect of inhalation of catecholamines
arrhythmias

(but inhalation is effective)
increased levels of catecholamines in the urine?
pheochromocytoma