Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
51 Cards in this Set
- Front
- Back
|
what do alpha adrenoceptors generally mediate?
exception? |
excitation of organ systems
exception: intestine motility decreased |
|
|
what do beta adrenoceptors generally mediate?
exception? |
inhibition
exception: the heart |
|
|
adrenergic receptors that mediate classic sympathetic reactions at end organs
|
alpah-1
|
|
|
Where are alpha-2 adrenoceptors?
|
presynaptic SNS neurons
(some postsynaptic SNS effectors) |
|
|
Where are beta-1 adrenoreceptors?
|
heart (classic)
adipocytes |
|
|
Where are beta-2 adrenoceptors?
|
smooth muscle and most other sites
|
|
|
Where are beta-3 adrenoceptors?
|
adipocytes
|
|
|
Alpha-1 signal transduction pathway?
|
Gq--> PLC --> IP3 --> PKC --> Ca
|
|
|
Alpha-2 signal transduction pathway?
|
Gi --> inhibit adenylyl cyclase
|
|
|
Beta-1 and -2 signal transduction pathways?
|
Gs --> stimulate adenylyl cyclase
|
|
|
The catecholamines of the ANS.
|
Epi, NE, and isoproterenol
|
|
|
rank the order of potency of catecholamines for alpha adrenoceptors
|
Epi > NE >> Iso
|
|
|
order of potency of catecholamines for beta-1 adrenoceptor
|
Iso > Epi = NE
|
|
|
order of potency of catecholamines for beta-2 adrenoceptor
|
Iso >= Epi >> NE
|
|
|
an almost pure beta adrenergic agonist
|
Iso
|
|
|
Catacholamine:
powerful alpha agonist that stimulates beta-1 adrenoceptors (but not so much beta-2) |
NE
|
|
|
Catecholamine:
relatively high affinity for all adrenoceptors |
Epi
|
|
|
NE effect on Heart rate?
|
decrease
b/c BP goes high, and reflex bradycardia kicks in |
|
|
NE effect on peripheral resistance?
|
increase
|
|
|
NE effect on BP?
|
increase
|
|
|
Epi effect on peripheral resistance?
|
high dose = increase
low/moderate dose = decrease |
|
|
BP change after Epi injection?
|
No appreciable change
|
|
|
Heart rate change after Epi injection?
|
increase
|
|
|
Iso is a _____-agonist
|
beta
|
|
|
Peripheral resistance change with Iso injection
|
decrease
|
|
|
BP change with Iso injection
|
decrease
|
|
|
Heart rate change with Iso injection?
|
increase
|
|
|
alpha-blocker effect on peripheral resistance
|
decrease PR
|
|
|
alpha blocker effect on BP
|
decrease BP
|
|
|
alpha blocker effect on pulse rate?
|
increase (not much)
|
|
|
alpha-blocker + Epi effect on peripheral resistance?
|
decrease (alot)
|
|
|
alpha-blocker + Epi effect on BP?
|
decrease
|
|
|
alpha-blocker + Epi effect on heart rate?
|
increase
|
|
|
alpha-blocker + NE effect on peripheral resistance?
|
no appreciable change
|
|
|
alpha-blocker + NE effect on BP?
|
no appreciable increase
|
|
|
alpha-blocker + NE effect on heart rate?
|
increase
|
|
|
What is the website with NE, Epi, Iso games?
|
www.kumc.edu/research/
medicine/pharmacology/ CAI/webCAl/as71.htm |
|
|
bronchial smooth muscle has ________adrenoceptors
|
beta-2
|
|
|
when treating bronchial conditions, be careful with nonselective beta ________
|
agonists
|
|
|
beta-2 agonists delay premature ______
|
labor
(relax uterine smooth muscle) |
|
|
beta agonists relax detrusor muscle while alpha agonist contract ________
|
sphincther
|
|
|
alpha and beta stimulation effects on GI muscle
|
relax GI muscle,
reduce motility, may contract sphincters |
|
|
alpha simulation affects what muscle to cause mydriasis
|
contracts radial muscle
|
|
|
why do catecholamines have a limited effect on the CNS
|
does not cross BBB well
|
|
|
Why use Epi mixed with local anesthetics?
|
to decrease local bleeding by vasoconstriction and later, prevent extreme swelling
|
|
|
catecholamines that are powerful cardiac stimulants
|
Epi / Iso
|
|
|
Catecholamines for hypotensive crisis / shock
|
NE
|
|
|
why are catecholamines not effective orally
|
rapid conjucagion in GI tract
MAO and COMT in the liver |
|
|
preferred injection method of catecholamines
|
IV
|
|
|
Side effect of inhalation of catecholamines
|
arrhythmias
(but inhalation is effective) |
|
|
increased levels of catecholamines in the urine?
|
pheochromocytoma
|
