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75 Cards in this Set

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direct acting agents that mimic NE
sympathomimetic agents
adrenergic agents that have "indirect effect" work at the ________
nerve terminal

(enhance / inhibit NE release)
alpha-1 stimulating sympathmimetic amines
phenylephrine
methoxamine
alpha-2 stimulating sympathmimetic amines
clonidine
beta-1 stimulating sympathmimetic amines
dobutamine
beta-2 stimulating sympathmimetic amines
terbutaline
albuterol
primary use of phenylephrine
vasoconstrictor (nasal inhaler)
phenylephrine is used to treat hypotensive states like __________
shock or spinal anesthesia
phenylephrine is used as a nasal decongestant to treat _____________
rhinitis medicamentosa or rebound
phenylephrine's effect on the eye
mydriasis
phenylephrine is not a substrate for __________
COMT
clonidine is a alpha-2 adrenergic _____
agonist
clonidine is a direct vaso-_________
constrictor
clonidine's effect on BP
decreases
when removing clonidine therapy, why ween the pt slowly
rebound HTN
methoxamine is a alpha-______ agonist
alpha-1
methoxamine's effect on beta adrenorecptors?
none
primary use of methoxamine
vasoconstrictor
methoxamine is metabolized by
a- COMT
b- MAO
neither
Dobutamine is a ______ adrenergic agonist
beta-1
Dobutamine stimulates which adrenoreceptors
beta-1
beta-2
alpha
dobutamine's effect on CO
increases
Blood vessel effect of dobutamine
vasodilator
terbutaline and albuterol are selective ______ agonists
beta-2
primary use of terbutaline and albuterol
broncodilator
terbutaline and albuterol may inhiibit ____ cell secretion
mast
metabolization of terbutaline and albuterol
not COMT or MAO (long acting)
how are side effects limited with terbutaline and albuterol
inhalation
amphetamine enhances _____ release
NE
makes for an effective Diet pill
amphetamine

(dependency and tolerance)
Is amphetamine direct or indirect acting?
indirect
mixed acting adrenergic agonists
ephedrine and metraminol
Ephedrine indirect effect and direct effect
indirect - induces NE release

dir - stims alpha and beta adrenoceptors
Herbal Ephedrine
Ma Huang
Ephedrine + ____ = diet pill
with caffeine
ephedrine causes ______ incontinence
urinary
bronchodilator replacing ephedrine
beta-2 agonists
Direct and indirect effects of metraminol
dir: stims alpha-1 adrenoceptors (weak beta effects like phenylephrine)

indirect: replaces NE in storage granules ("false neurotransmitter")
metaraminola treats _______ states
hypotensive states
drug that causes covalent, irreversible blockade requiring days to recover
phenoxybenzamine
primary use for phenoxybenzamine
pheochromocytoma
phenoxybenzamine causes urinary __________
obstruction (BPH)
phenoxybenzamine causes autonomic ______-reflexia
hyper
side effects of phenoxybenzamine
orthostatic hypotension
nasal congestion
ejaculatory dysfunction
phenoxybenzamine is a ______ adrenergic antagonist
alpha
phentolamine is a ______ adrenergic antagonist
alpha
primary use of phentolamine
pheochromocytoma
phentolamine is not a good general antihypertensive b/c ______
reflex tachycardia (alpha-2 block)
phentolamine causes _______ dysfunction
erectile

(but it makes more sense that it would be ejaculatory dysfunction)
side effects of phentolamine
orthostatic hypotension
reflex cardiac stimulation
nasal congestion
prazosin is a selective ______ antagonist
alpha-1
primary use of prazosin
antihypertensive
prazosin has little or no _______ blockade
alpha-2
prazosin improves urinary flow in _______ (condition)
BPH
why give prazosin at bed time?
first does phenomenon of syncope
propranonolol blocks both ________ adrenoreceptors
beta 1 and 2
primary uses of propranolol
antihypertensive
ischemic heart disease
(little effect on normal heart or BP at rest)
why not use propranolol on pts with asthma or COPD
can lead to bronchoconstriction
why not use propranolol on pts with DM
masks onset symptoms of hypoglycemia (increase HR and BP)
propranolol has a membrane ________ effect
stabilizing
propranolol treats _____-thyroidism
hyper
eye problem treated with propranolol
glaucoma
metoprolol is a selective ______ blocker
beta-1
primary uses of metoprolol
antiHTN
IHD
(little effect on normal heart or BP at rest )
metoprolol: good for lung dx pts?
less tendency for bronchoconstriction
guanethidine causes catecholamine depletion by ________
replacing NE in storage vesicles (MAO) and interferes with vesicle release
guanethidine is a VERY powerful anti_________
HTN
side effects of guanethidine
orthostatic hypotension
GI/diarrhea
male sexual disturbances
bad with MAOI
snakeroot
reserpine
how does reserpine cause catecholamine depletion
inhibs amine uptake into vesicles
irreversible
inhibs DO uptake as well
BLOCKS NE STORAGE and SYNTHESIS
Side effects of reserpine
depression, sedation, suicide
methyl tyrosine inhibits ________ enzyme
tyrosine hydroxylase
side effects of methyl tyrosine
sympathetic depression
sedation, anxiety
alpha-methyldopa is a "false ______"
transmitter
preferred to treat HTN in pregnancy
alpha-methlydopa