Which Drug...?

Front 1

Which AB is the original penicillin and is used for Strep. pneumoniae?

Back 1

Penicillin G

Front 2

Which AB is the oral form of penicillin, acid stable, and used for Streptococcal pharyngitis?

Back 2

penicillin V

Front 3

Which AB has a broader spectrum then penicillin G, hitting more Gm- organisms, and can kill E. coli and other enterics?

Back 3

aminopenicillins (ampicillin and amoxicillin)

Front 4

Which ABs are penicillinase-resistant?

Back 4

methicillin, nafcillin, oxacillin

Front 5

Which AB is the drug of choice for serious S. aureus infections, such as cellulitis, endocarditis, and sepsis?

Back 5

nafcillin

Front 6

Which Abs are oral beta-lactamase resistant drugs that are not good against Gm- bacteria?

Back 6

cloxacillin and dicloxacillin

Front 7

Which ABs are carboxypenicillins and are anti-pseudomonas?

Back 7

ticarcillin and carbenicillin

Front 8

Which ABs are ureidopenicillins and anti-pseudomonas?

Back 8

piperacillin and mezlocillin

Front 9

What are the beta-lactamase inhibitors?

Back 9

clavulonic acid, sulbactam, and tazobactam

Front 10

Which generation of cephalosporins are most active against Gm+ and S. pneumoniae?

Back 10

First gen

Front 11

Which are the 1st generation cephalosporins?

Back 11

cephalothin, cephapirin, cephradine, cephalexin, cefazolin, cefadroxil

Front 12

Which generation of cephalosporins has medium action against Gm+ and Gm-?

Back 12

2nd gen

Front 13

Which generation of cephalosporins is most active against Gm- and S. pneumoniae?

Back 13

third gen

Front 14

What are the 2nd gen cephalosporins?

Back 14

cefamandole, cefaclor, cefuroxime, cefoxitin, cefotetan, cefmetazole, cefonicid, cefprozil, loracarbef

Front 15

What are the 3rd gen cephalosporins?

Back 15

ceftriaxone, ceftazidime, cefotaxime, ceftzoxime, ceftibuten, cefixime, cefoperazone, cefpodoxin, cefetamet

Front 16

What is the 4th gencephalosporin?

Back 16

cefepime

Front 17

What are 1st gencephalosporins used for?

Back 17

as an alternative to penicillin for staph and strep; prophylactics before surgery

Front 18

What are 2nd gencephalosporins used for?

Back 18

community-acquired pneumonia (cefuroxime) Gm- infections

anaerobic infections (cefotetan, cefoxitin, cefmetazole)

Front 19

What are 3rd gencephalosporins used for?

Back 19

multi-drug resistant aerobic Gm- hospital-acquired organisms

Front 20

Which ABs are the oncly cephalosporins affective against P. aeruginosa?

Back 20

ceftazidime, cefoperazone, and cefepime

Front 21

Whichcephalosporin has the best CSF coverage?

Back 21

ceftriaxone

Front 22

Which cephalosporin is used for CA-pneumonia

Back 22

cefuroxime

Front 23

Whichcephalosporins are used for anaerobic infections?

Back 23

cefotetan, cefoxitin, cefmetazole

Front 24

Which AB kills Gm-, Gm+, anaerobes, but has resistance among MRSA, some pseudomonas, and mycoplasmas?

Back 24

Imipenem

Front 25

Which AB must be used in concert w/ cilastin, a dihydropeptidase inhibitor, and lowers the seizure threshold?

Back 25

Imipenem

Front 26

Which AB is as powerful as imipenem but is stable against dihydropeptidase and has a reduced potential for causing seizures?

Back 26

Meropenem

Front 27

Which AB is used only for Gm- aerobic organisms, often in combination w/ vancomycin or clindamycin, and does not cross react w/ penicillin?

Back 27

Aztreonam

Front 28

Which ABs inhibit the 50s subunit?

Back 28

chloramphenicol, clindamycin, linezolid, erythromycin

Front 29

Which ABs inhibit the 30s subunit?

Back 29

tetracyline, aminoglycosides

Front 30

Which is the only AB that inhibits the ribosome that cannot be absorbed orally?

Back 30

aminoglycoside

Front 31

Which AB kills most clinically important bacteria (Gm+, Gm-, anaerobes, Bacteroides fragilis), but has rare but severe side affects?

Back 31

Chloramphenicol

Front 32

Which AB is used to treat bacterial meningitis when the organism is not yet known and the pt has severe allergies to penicillins?

Back 32

Chloramphenicol

Front 33

Which AB is used to treat young children and pregnant women who have Rocky Mountain Spotted Fever (in place of tetracycline)?

Back 33

Chloramphenicol

Front 34

Which AB can cause aplastic anemia and Grey baby syndrome?

Back 34

Chloramphenicol

Front 35

Which AB inhibits many Gm+ and anaerobes and is used w/ aminoglycoside for penetrating wound infections of the abdomen and infections of the female genital tract?

Back 35

Clindamycin

Front 36

Which AB is a common cause of pseudomembrane colitis (by allowing C. diff to proliferate)?

Back 36

Clindamycin

Front 37

Which AB is used for resistant Gm+ organisms and causes headaches and GI upset?

Back 37

Linezolid

Front 38

Which AB is active against Gm+ but is inactive against most Gm- other than Legionella and Chlamydia?

Back 38

Erythromycin

Front 39

Which AB is the drug of choice for community-acquired pneumonia and Legionnaire's and is used as an alt. to penicillin for strep and staph in penicillin allergic pts?

Back 39

Erythromycin

Front 40

Which AB is one of the safest ABs, causing occasional GI irritation and rare cholestatic hepatitis?

Back 40

Erythromycin

Front 41

Which AB chelates w/ cations in milk and milk products and will pass through the intestine w/out being absorbed?

Back 41

Tetracycline

Front 42

Which ABs are used to treat venereal diseases (caused by Chlamydia), walking pneumonia, Brucella, rickettsia, and acne?

Back 42

Tetracycline/Doxycycline

Front 43

Which AB causes GI irritation, phototoxic dermatitis, renal and hepatic toxicity, discolored teeth, and depressed bone growth?

Back 43

Tetracycline/Doxycycline

Front 44

Which AB is used to treat Chlamydia?

Back 44

Doxycycline

Front 45

Which AB is often given w/ penicillins to facilitate diffusion?

Back 45

Aminoglycosides

Front 46

Which AB kills Gm- aerobic enterics and P. aeruginosa?

Back 46

Aminoglycosides

Front 47

Which AB is the oldest Aminoglycoside, and thus many bugs are resistant?

Back 47

Streptomycin

Front 48

Which AB is the most commonly usedAminoglycoside, used for in-hospital infections?

Back 48

Gentamicin

Front 49

Which AB is an Aminoglycoside that's good against P. aeruginosa?

Back 49

Tobramycin

Front 50

Which AB is anAminoglycoside with the broadest spectrum and is good for nosocomial infections?

Back 50

Amikacin

Front 51

Which AB is anAminoglycoside with broad coverage, but its toxicity means it can only be used topically?

Back 51

Neomycin

Front 52

Which AB is anAminoglycoside that is used for preoperative coverage before GI surgery?

Back 52

Netilmicin

Front 53

Which ABs cause CN VIII toxicity, renal toxicity, and rarely neuroblockade?

Back 53

Aminoglycosides

Front 54

Which AB is an alt. to treat gonorrhea?

Back 54

Spectinomycin

Front 55

With which ABs do you treat active TB infections?

Back 55

Isoniazid, rifampin, and pyrazinamide---can cause liver toxicity

Front 56

With which AB do you treat latent TB infections?

Back 56

Isoniazid

Front 57

Which AB causes red/orange urine, sweat, and/or tears?

Back 57

Rifampin

Front 58

Which ABs are used to treat leprosy?

Back 58

dapsone, rifampin, and clofazimine

Front 59

Which group of ABs act by inhibiting DNA gyrase, resulting in the breakage of the bacterial DNA structure?

Back 59

Fluoroquinolones

Front 60

Which AB causes photosensitivity in up to 8% of pts and can prolong the Q-T interval on the EKG, which can predispose a patient to the arrhythmia Torsades de pointer?

Back 60

Sparfloxacin

Front 61

Which AB treats all Gm+ bugs?

Back 61

Vancomycin

Front 62

Which AB causes red man syndrome w/ its rapid infusion?

Back 62

Vancomycin

Front 63

Which ABs act synergistically to kill many gram-positive and gram-negative bacteria by inhibiting TH4 production but at different steps?

Back 63

trimethoprim (TMP) and sulfamethoxazole (SMX)

Front 64

Which ABs cause adverse affects in patients w/ AIDs including skin rashes and bone marrow suppression?

Back 64

trimethoprim (TMP) and sulfamethoxazole (SMX)

Front 65

Which ABs have no anaerobic coverage, but have a wide gram-negative and gram-positive coverage (and even cover some Protozoans)?

Back 65

trimethoprim (TMP) and sulfamethoxazole (SMX)

Front 66

Which AB is given prophylactically before bowel surgery?

Back 66

sulfathalidine

Front 67

Which ABs should not be used in the last month of pregnancy or during breast feeding because they cause Kernicterus?

Back 67

Sulfonamides

Front 68

Which ABs displace warfarin and thus increase bleeding time?

Back 68

Sulfonamides

Front 69

With which AB should milk and milk products be avoided?

Back 69

Ciprofloxacin

Front 70

With which AB, sometimes used to treat Malaria, should a pt remain upright for 30 min after taking to avoid complications w/ the esophagus, such as ulceration?

Back 70

Doxycycline

Front 71

Which AB is used to treat cholera?

Back 71

Doxycyline

Front 72

Which AB is used to treat Shigella outbreaks, even in preschool-aged children?

Back 72

Azithromycin

Front 73

Which AB is bacteriocidal, except for enterococci, for which it is only bacteriostatic?

Back 73

Vancomycin

Front 74

Which AB is effective against most staphylococci (including MRSA), is used synergistically w/ aminoglycosides, and has good activity against clostridia, anaerobic strep, Listeria, pneumococci, Gp A strep, and Corynebacteria?

Back 74

Vancomycin

Front 75

Which AB is poorly distributed into bile, eyes, and normal meninges, has 7-21% entry in inflamed meninges, and 20-30% entry into bone?

Back 75

Vancomycin

Front 76

Which AB can cause reversible neutropenia, renal insufficiency, and irreversible hearing loss?

Back 76

Vancomycin

Front 77

Which AB is used for treatment or prophylaxis for Gm+ in pts allergic to B-lactams, Gm+ resistant to B-lactams, Corynebacterium JK, and severe Clostridium difficile colitis?

Back 77

Vancomycin

Front 78

Which drug is a synthetic derivative of vancomycin, inhibits cell-wall synthesis, and depolarizes cell membranes?

Back 78

Telavancin

Front 79

Which AB has good penetration into alveolar lining fluid and macrophages, is excreted via kidneys, only needs to be administered once daily, and does not require measurement of levels?

Back 79

Telavancin

Front 80

Which AB can cause altered taste, nausea, vomiting, foamy urine, pruritis, and elevated serum creatinine?

Back 80

Telavancin

Front 81

Which AB is used for skin and soft tissue infections, but should be avoided w/ pregnancy and in infants?

Back 81

Telavancin

Front 82

Which AB is a 2nd gen lipoglycopeptide and has a long half life that allows for once weekly dosing?

Back 82

Dalbavancin

Front 83

Which AB is a 2nd gen lipoglycopeptide and has a long half life that allows for single dose therapy?

Back 83

Oritavacin

Front 84

Which AB causes peripheral IV pain, phlebitis, arthralgias, myalgias, and inhibits CYP 4503A4?

Back 84

Quinupristin/dalfopristin

Front 85

Which AB inhibits protein synthesis by preventing formation of the 70S initiation complex, and therefore has no cross resistance w/ other ABs that inhibit protein synthesis?

Back 85

Oxazolidinones (Linezolid, Tedizolid)

Front 86

Which AB has 80-100% bioavailability after oral dose, and is given every 12-24 hours?

Back 86

Oxazolidinones (Linezolid, Tedizolid)

Front 87

Which AB can cause bone marrow toxicity w/ prolonged use and CNS toxicity w/ psych meds?

Back 87

Oxazolidinones (Linezolid, Tedizolid)

Front 88

Which AB is reserved for VRE, some MRSA infections, and is used for some rapid-growing non-TB mycobacterial infections?

Back 88

Oxazolidinones (Linezolid, Tedizolid)

Front 89

Which AB has Ca-dependent binding to bacterial plasma membranes, causing membrane depolarization and cell death, and inhibits cell wall synthesis?

Back 89

Daptomycin

Front 90

Which AB is effective against MMSA, MRSA, VISA, VRSA, VRE, and Pen-R?

Back 90

Daptomycin

Front 91

Which AB can cause increased CPK and muscle discomfort and acute eosinophilic pneumonia?

Back 91

Daptomycin

Front 92

Which AB is the 5th generation cephalosporin?

Back 92

Ceftaroline

Front 93

Which AB inhibits cell wall synthesis and can bind to PBP-2a (MRSA strains) and PBP-2x (Pcn-R S. pneumo)?

Back 93

Ceftaroline

Front 94

Which AV is used to treat influenza, as well as for prophylaxis?

Back 94

Oseltamivir

Front 95

Which AV is used to treat polyoma and papilloma viruses?

Back 95

Cidofovir

Front 96

Which AV is used to treat chronic HBV?

Back 96

lamivudine, adefovir dipivoxil, of famiciclovir