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22 Cards in this Set

  • Front
  • Back
When does glycolysis occur?
In fed state in ALL cells
RBC and brain in fed and fasted
Where is glycolysis take place?
Cytosol
Summerize the catabolic pathway of glycolysis in 3 basic steps
1. Oxidation of carbons (glucose to pyruvate)
2. reduction of NAD+ to NADH
3. Production of ATP from ADP
Is glycolysis anaerobic or aerobic?
Glycolysis is anaerobic
Name the products of glycolysis
(2) 3carbon Pyruvates, ATP, NADH
Enzyme that is the entry point of glycolysis
Hexokinase/glucokinase (in liver)
Enzyme that is the main site of glycolysis regulation
PFK-1 (phosphofructo kinase-1)
Enzyme that conversts NAD+ to NADH
Glyceraldehyde 3-phosphate dehydrogenase
Enzyme that is regulate in gluconeogenesis
Pyruvate kinase
Name the enzyme and place that this reaction would occur:
Glucose-6p ---> glucose
glucose-6 phosphatase in liver
The extent of glycolysis in a cell depends on...
Fed/fasted state blood glucose except for RBC and brain which always do glycolysis
How does hexokinase/glucokinase comitt glucose to glycolysis?
Glucose is phosphoralated to glucose-6-p. To DEphosphoralate it you must take it to the liver and use glucose-6-phosphatase.
What is the activator of PFK?
Fructose 6-p and AMP
Also need a little ATP
What is the inhibitor of PFK?
Large ammounts of ATP
NAD+ is reduce to NADH by what enzyme?
Glyceraldehyde 3-phosphate dehydrogenase
When does pyruvate enter the mitochondria?
Under aerobic condtions
Pyruvate is oxidized to Acetyl CoA by which enzyme?
Pyruvate dehydrogenase
Is the conversion of pyruvate to Acetyl CoA reversible?
NO! You are now comitted!
Fatty acid carbons that are converted to Acetyl CoA can never be converted into?
Glucose
How is pyruvate dehydrogenase regulated?
Varying ammounts of substrates (pyruvate) and products (Acetyl CoA) regulate pyruvate dehydrogenase.
Name the four uses of pyruvate
1. acetyl CoA
2. lactate
3. oxaloacetate
4. alanine
What is the enzyme that converts pyruvate to oxaloacetate?
Pyruvate carboxylase in mitochondria