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22 Cards in this Set
- Front
- Back
When does glycolysis occur?
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In fed state in ALL cells
RBC and brain in fed and fasted |
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Where is glycolysis take place?
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Cytosol
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Summerize the catabolic pathway of glycolysis in 3 basic steps
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1. Oxidation of carbons (glucose to pyruvate)
2. reduction of NAD+ to NADH 3. Production of ATP from ADP |
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Is glycolysis anaerobic or aerobic?
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Glycolysis is anaerobic
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Name the products of glycolysis
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(2) 3carbon Pyruvates, ATP, NADH
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Enzyme that is the entry point of glycolysis
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Hexokinase/glucokinase (in liver)
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Enzyme that is the main site of glycolysis regulation
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PFK-1 (phosphofructo kinase-1)
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Enzyme that conversts NAD+ to NADH
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Glyceraldehyde 3-phosphate dehydrogenase
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Enzyme that is regulate in gluconeogenesis
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Pyruvate kinase
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Name the enzyme and place that this reaction would occur:
Glucose-6p ---> glucose |
glucose-6 phosphatase in liver
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The extent of glycolysis in a cell depends on...
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Fed/fasted state blood glucose except for RBC and brain which always do glycolysis
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How does hexokinase/glucokinase comitt glucose to glycolysis?
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Glucose is phosphoralated to glucose-6-p. To DEphosphoralate it you must take it to the liver and use glucose-6-phosphatase.
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What is the activator of PFK?
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Fructose 6-p and AMP
Also need a little ATP |
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What is the inhibitor of PFK?
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Large ammounts of ATP
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NAD+ is reduce to NADH by what enzyme?
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Glyceraldehyde 3-phosphate dehydrogenase
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When does pyruvate enter the mitochondria?
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Under aerobic condtions
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Pyruvate is oxidized to Acetyl CoA by which enzyme?
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Pyruvate dehydrogenase
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Is the conversion of pyruvate to Acetyl CoA reversible?
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NO! You are now comitted!
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Fatty acid carbons that are converted to Acetyl CoA can never be converted into?
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Glucose
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How is pyruvate dehydrogenase regulated?
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Varying ammounts of substrates (pyruvate) and products (Acetyl CoA) regulate pyruvate dehydrogenase.
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Name the four uses of pyruvate
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1. acetyl CoA
2. lactate 3. oxaloacetate 4. alanine |
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What is the enzyme that converts pyruvate to oxaloacetate?
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Pyruvate carboxylase in mitochondria
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