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34 Cards in this Set
- Front
- Back
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meyer overton rule?
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The potency of an anesthetic agent is directly proportional to their lipid solubility
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The Unitary Hypothesis
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All inhalation agents share a common mechanism of action at the molecular level
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Factors that speed induction and recovery [7]
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Elimination of rebreathing
High fresh gas flows Low anesthetic-circuit volume Low absorption by the anesthetic circuit Decreased solubility High cerebral blood flow Increased ventilation |
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Isoflurane has been associated with coronary steal especially with ________?
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Fixed stenotic lesions
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The higher the fresh gas flow rate, the ________ the breathing system volume, and the ________ the circuit absorption, the closer the inspired gas concentration witll be to the fresh gas concentrations.
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Smaller
Lower |
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The greater the uptake, the _____________ the rate of rise of the alveolar concentration and the lower the FA:FI ratio.
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Slower
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The actual composition of the inspired gas mixture depends mainly on? [3]
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FGF rate
Breathing system volume Circuit absorption |
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The greater the uptake of anesthetic agent, the ___________ the difference between inspired and alveolar concentrations, and the ___________ the rate of induction.
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Greater
Slower |
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Three factors that affect anesthetic uptake?
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Blood solubility
Alveolar blood flow Difference in partial pressure between alveolar gas and venous blood. |
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The transfer of anesthetic from blood to tissues is determined by what 3 factors analogous to systemic uptake?
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Tissue:blood partition coefficient
Tissue blood flow Difference in partial pressure between arterial blood and the tissue |
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________ states predispose patients to overdose with soluble agents as the
rate of rise in alveolar concentration will be markedly increased. |
Low output states
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What is the concentration effect?
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Increasing the inspired concentration not only increases the alveolar concentration but also increases its rate of rise. (FA/FI)
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The presence of V/Q mismatch will ________ the alveolar-arterial difference.
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Increase
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Nitrous oxide contraindicated in? [6]
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Air embolus
Pneumothorax Acute intestinal obstruction Intercranial air following dural closure Intraocular air bubbles Tympanic membrane grafting |
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The _________ fraction of a drug is reabsorbed in the renal tubules.
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Nonionized
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No droperidol with?
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Parkinsons
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Thiopental induction dose? Sedation dose?
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3-6mg/kg
0.5-1.5 mg/kg |
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Methohexital induction dose? Sedation dose?
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1-2 mg/kg
0.2-0.4 mg/kg |
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Reminfentanil loading dose? Maintenance?
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1 ug/kg
0.5-20 ug/kg/min |
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fentanil intraop dose?
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2-150ug/kg
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sufentanil intraop dose?
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.25-30 ug/kg
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alfentanil intraop dose?
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8-100 ug/kg
0.5-3.0 ug/kg/min |
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ketamine induction dose?
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IV 1-2 mg/kg
IM 3-5 mg/kg |
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Propofol induction dose? Sedation?
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1-2.5 mg/kg
25-200 ug/kg/min sedation 25-100 ug/kg/min |
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Etomidate induction dose?
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.2-.5 mg/kg
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succinylcholine intubation dose? Onset/duration?
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1.0 mg/kg
30 sec/5-10 min |
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rocuronium intubation dose? Onset/duration?
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0.8 mg/kg
1.5min/35-75 min |
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mivacurium intubation dose? Onset/duration?
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0.2 mg/kg
2.5-3.0/15-20 |
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atracurium intubation dose? Onset/duration?
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0.5 mg/kg
2.5-3.0/30-45 |
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vecuronium intubation dose? Onset/duration?
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0.12 mg/kg
2.0-3.0/45-90 |
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neostigmine dose? Give with?
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0.04-0.08 mg/kg
glycopyrolate 0.2 mg per mg of neostigmine |
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pyridostigmine dose? Give with?
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0.1-0.4 mg/kg
glycopyrolate 0.05 mg per mg of pyridostigmine |
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edrophonium dose? Give with?
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0.5-1.0 mg/kg
atropine 0.014 mg per mg of edrophonium |
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physostigmine dose? Give with?
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0.01-0.03 mg/mg
anticholinergic usually not necessary |
