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34 Cards in this Set

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meyer overton rule?
The potency of an anesthetic agent is directly proportional to their lipid solubility
The Unitary Hypothesis
All inhalation agents share a common mechanism of action at the molecular level
Factors that speed induction and recovery [7]
Elimination of rebreathing
High fresh gas flows
Low anesthetic-circuit volume
Low absorption by the anesthetic circuit
Decreased solubility
High cerebral blood flow
Increased ventilation
Isoflurane has been associated with coronary steal especially with ________?
Fixed stenotic lesions
The higher the fresh gas flow rate, the ________ the breathing system volume, and the ________ the circuit absorption, the closer the inspired gas concentration witll be to the fresh gas concentrations.
Smaller
Lower
The greater the uptake, the _____________ the rate of rise of the alveolar concentration and the lower the FA:FI ratio.
Slower
The actual composition of the inspired gas mixture depends mainly on? [3]
FGF rate
Breathing system volume
Circuit absorption
The greater the uptake of anesthetic agent, the ___________ the difference between inspired and alveolar concentrations, and the ___________ the rate of induction.
Greater
Slower
Three factors that affect anesthetic uptake?
Blood solubility
Alveolar blood flow
Difference in partial pressure between alveolar gas and venous blood.
The transfer of anesthetic from blood to tissues is determined by what 3 factors analogous to systemic uptake?
Tissue:blood partition coefficient
Tissue blood flow
Difference in partial pressure between arterial blood and the tissue
________ states predispose patients to overdose with soluble agents as the
rate of rise in alveolar concentration will be markedly increased.
Low output states
What is the concentration effect?
Increasing the inspired concentration not only increases the alveolar concentration but also increases its rate of rise. (FA/FI)
The presence of V/Q mismatch will ________ the alveolar-arterial difference.
Increase
Nitrous oxide contraindicated in? [6]
Air embolus
Pneumothorax
Acute intestinal obstruction
Intercranial air following dural closure
Intraocular air bubbles
Tympanic membrane grafting
The _________ fraction of a drug is reabsorbed in the renal tubules.
Nonionized
No droperidol with?
Parkinsons
Thiopental induction dose? Sedation dose?
3-6mg/kg
0.5-1.5 mg/kg
Methohexital induction dose? Sedation dose?
1-2 mg/kg
0.2-0.4 mg/kg
Reminfentanil loading dose? Maintenance?
1 ug/kg
0.5-20 ug/kg/min
fentanil intraop dose?
2-150ug/kg
sufentanil intraop dose?
.25-30 ug/kg
alfentanil intraop dose?
8-100 ug/kg
0.5-3.0 ug/kg/min
ketamine induction dose?
IV 1-2 mg/kg
IM 3-5 mg/kg
Propofol induction dose? Sedation?
1-2.5 mg/kg
25-200 ug/kg/min

sedation 25-100 ug/kg/min
Etomidate induction dose?
.2-.5 mg/kg
succinylcholine intubation dose? Onset/duration?
1.0 mg/kg
30 sec/5-10 min
rocuronium intubation dose? Onset/duration?
0.8 mg/kg
1.5min/35-75 min
mivacurium intubation dose? Onset/duration?
0.2 mg/kg
2.5-3.0/15-20
atracurium intubation dose? Onset/duration?
0.5 mg/kg
2.5-3.0/30-45
vecuronium intubation dose? Onset/duration?
0.12 mg/kg
2.0-3.0/45-90
neostigmine dose? Give with?
0.04-0.08 mg/kg
glycopyrolate 0.2 mg per mg of neostigmine
pyridostigmine dose? Give with?
0.1-0.4 mg/kg
glycopyrolate 0.05 mg per mg of pyridostigmine
edrophonium dose? Give with?
0.5-1.0 mg/kg
atropine 0.014 mg per mg of edrophonium
physostigmine dose? Give with?
0.01-0.03 mg/mg
anticholinergic usually not necessary