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16 Cards in this Set
- Front
- Back
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Define autograft
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self tissue transplant
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Define isograft
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twin tissue transplant
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Define allograft
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tissue transplant from another species
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Define xenograft
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transplant from another species
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Describe MHC molecule
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- inherited by parents
- highly polymorphic 6 x class I 12 x class 2 |
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Where is the MHC/HLA located?
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chromosome 6
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What is located on the Class II MHC locus
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DP DQ DR
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What is located on the Class I MHC locus?
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A B C
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What are the gene products of Class I and Class II MHC
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Class II - DP alpha beta, DQ ab, DR ab
Class I - HLA B, HLA A, HLA C |
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Define class I MHC
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Define Class II
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Which MHC class presents to CD4+ cells
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Class II
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Which class MHC present to CD8+
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Class I
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Describe class I MHC
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four regions, alpha 1 and 2 which form the peptide binding cleft. alpha 3 goes accross the membrane and signal. Beta 2 microglobulin is associated but does not bind to the membrane.
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Describe the binding cleft in the MHC class I
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nine amino acids to recognise a pathogen. Positions 2 and 9 are anchor residues. 2 is the basement of the groove - and needs to be an aa of the right affinity, but may be just related whereas positions like aa 1 need to be a certain amino acid.
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Describe the binding cleft for MHC class II
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open on one side
can accept longer polypetptide chain 9 aa to 25 aa more binding pockets locations are 1,4,6,7,9 binding pockets bind down in the basement, creating a conformation which we think may induce a t cell response transmembrane and signal\ open binding cleft both sides go through transmemrane |
