Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
What will hapen to naive B cells if they are not activated by antigen binding?
|
they will die
|
|
|
What do cytokines help B cells to do?
|
help them switch to antibody isotype with appropriate function
|
|
|
What will happen to naive T cells if not activated by binding MHC/peptide?
|
they will die
|
|
|
Cytokines produced by activated CD4+ T helper cells help activate what?
|
CD8+ CTLS
|
|
|
What does CD28 bind to?
|
B7
|
|
|
What does the integrin LFA-I bind to?
|
ICAM-I
|
|
|
What does VLA-4 bind to?
|
VCAM-I
|
|
|
What happens to the affinity state of LFA-I after chemokine exposure?
|
it changes to a higher one
|
|
|
What will happen if the APC does not express B& and secrete cytokines?
|
T cells will not receive the "second signal" and will not become activated
|
|
|
What does receptor clustering do?
|
activates a kinase which phosphorylates ITAMS on CD3 and zeta chain in the TCR complex
|
|
|
Signaling results in the secretion of what?
|
cytokines
|
|
|
Signaling results in the expression of new receptors by the T cell which are..?
|
CD40 ligand, IL-2, IFN-y, IL-4, IL-2R
|
|
|
TH1 makes what?
|
IL-2 and IFN-y
|
|
|
TH2 makes what?
|
IL-4
|
|
|
Why is IL-2 important for T cells?
|
it is a very important growth factor
|
|
|
How do CD4+ T cells help activate CD8+ T cells?
|
cytokines from THI help prime CD8+ T cells
|
|
|
B cell activation complex contains what?
|
CR2, CD19, and CD81
|
|
|
ITAM on what provides "signal two" for B cell activation?
|
CD19
|
|
|
What is the role of antibody feedback mechanism?
|
prevents unnecessary B cell activation
|
|
|
When a T cell is activated what happens to the expression of CCR7 and CXCR5?
|
CCR7 decreases and CXCR5 increases(B cells to the opposite causeing a meeting near the edge of B cell follicles)
|
|
|
When TCR on T cell binds MHC II on a B cell, T cell begins to express what?
|
CD40 ligand
|
|
|
What is required to help proliferation/differentiation of a B cell?
|
CD40L interaction between B and T cell, and cytokines
|
|
|
How is CD40L involved in isotype formation?
|
It is required for B cells to switch from initial production of IgM to another isotype
|
|
|
Switching to IgGI ot IgG3 is stimulated by what?
|
IFN-y
|
|
|
Switching to IgE is stimulated by what?
|
IL-4
|
|
|
Switching to IgA is stimulated by what?
|
TFG-B
|
