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12 Cards in this Set
- Front
- Back
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What is the difference between an adverse drug event and an adverse drug reaction?
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Event: bad thing during / following therapy
Reaction: drug even likely due to drug |
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Def'n Type A
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Augmented, anticipated; dose dependent
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Def'n Type B
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Bizarre, pharmacologic + / - immune response
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Is nausea following digoxin Type A or B
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A
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Give an example of a Type B reaction.
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Phenytoin Hypersensitive Syndrome
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What is the SAFER MD checklist?
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Side fx
Alternative tx Forfeit of tx Expected benefit Regimen (dose etc) Monitoring Duration |
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What are 4 Categories of high risk drug?
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Anti
- biotics - inflammatories - convulsants - coagulants |
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How is Azathioprine metabolized?
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via xanthine oxidase and TPMT to non-toxic pathways; via a 3rd pathway to active / toxic metabolite
TPMT is polymorphic; risk of toxic OD |
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What happens when you mix Azathioprine and allopurinol?
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Allopurinol inhibits xanthine oxidase --> toxic OD
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What is a possible side effect of ticopidine?
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Aplastic anemia leading to febrile neutropenia --> death
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What is the ADR triad?
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Jaundice
Fever Rash |
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What is a rare but serious ADR to TMP-Sulfa?
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Toxic epidermal necrolysis
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