Week 3 Pbd Part 3 Digestion Of Fats By Pancreatic Secretion

Front 1

Digestion of fats by pancreatic secretion:

lipolytic enzymes:

include ___,___,and___

Back 1

pancreatic lipase , cholesterol esterase hydrolase, and phospholipase A2

Front 2

Digestion of fats by pancreatic secretion:

lipolytic enzymes:
___digests triglycerides rapidly, and hydrolyzes triglycerides to free fatty acid and 2-monoglycerides

Back 2

pancreatic lipase

Front 3

Digestion of fats by pancreatic secretion:

lipolytic enzymes:

___ hydrolyzes fatty acid from cholesterol ester

Back 3

cholesterol esterase hydrolase

Front 4

Digestion of fats by pancreatic secretion:

lipolytic enzymes:

___ hydrolyzes fatty acids from phospholipids

Back 4

phospholipase A

Front 5

Digestion of fats by pancreatic secretion:

lipolytic enzymes:


what does cholesterol esterase hydrolase do?

Back 5

hydrolyzes fatty acids from cholesterol ester

Front 6

Digestion of fats by pancreatic secretion:

lipolytic enzymes:

what do pancreatic lipase do?

Back 6

it hydrolyzes triglycerides rapidly into fatty acids and 2-monoglycerides

Front 7

absorption of fats:

fats are ferried to cell microvilli by __

Back 7

micelles

Front 8

absorption of fats:

after fats and monoglycerides enter the endoplasmic reticulum, new triglycerides are formed and released as ___

Back 8

chylomicrons

Front 9

absorption of fats:

after new triglycerides are formed, and released as chylomicrons, they flow through the ___ duct

Back 9

thoracic lymph duct

Front 10

absorption of water:

approximately __mL of water enter the GI tract/day

Back 10

9200 mL

Front 11

absorption of water:

about ___ to __ mL of water is lost in the feces

Back 11

50-100mL

Front 12

absorption of water:

water is transported through intestinal membrane by ___

Back 12

diffusion

Front 13

absorption of ions:

Na in the cell ___mEq/L

Back 13

50 mEq/L

Front 14

absorption of ions:

Na in the chyme = ___ mEq/L

Back 14

142 mEq/L

Front 15

absorptions of ions:

__ moves along the electrogradient to "follows Na"

and is absorbed in duodenum and jejunum

Back 15

Cl

Front 16

Absorption of ions:

Hepatic and pancreatic bicarb absorption in ___ and ___

Back 16

duodenum and jejunum

just like Cl

Front 17

absorption of ions:

HCO3

Indirect absorption:
hydrogen ions secreted in lumen in exchange for the absorbed ___

Back 17

Na

Front 18

Absorptions of ions:

HCO3

Indirect absorption:

carbonic acid is formed when ___ combines with ___

Back 18

H combines with bicarbonate

Front 19

Absorptions of ions:

HCO3

Indirect absorption:


carbonic acid is formed when H combines with bicarbonate

carbonic acid then forms __ and ___

Back 19

water and carbon dioxide

Front 20

Transport of ions:

K

what concentrates potassium in the lumen?

Back 20

absorption of water


(in colon, it may be secreted or absorbed depending on luminal concentration)

Front 21

Absorption of calcium:

where are the intestinal membrane calcium-binding proteins located?

Back 21

located in brush border

Front 22

Absorption of calcium:

where is calbindin located?

Back 22

cytoplasm of absorptive cells

Front 23

Absorption of calcium:

what is the purpose of calbindin?

Back 23

calcium binding proteins

which prevent free ions

Front 24

Absorption of calcium:

what do vesicles do?

Back 24

prevent free ions

Front 25

Absorption of calcium:

where is Ca - ATPase, Na/Ca countertransport located

Back 25

basolateral membrane of absorptive cells

Front 26

Absorption of iron:

a typical person absorbs __ to __ mg of iron daily

Back 26

15-20mg

Front 27

Absorption of iron:

what are the two sorces of dietary iron?

Back 27

heme
(meats- more readily absorbed)

nonheme-
(grain and vegetables)

Front 28

Absorption of iron:

what is mediates the uptake of heme and nonheme into cells:

Back 28

heme- HCP1

non-heme - DMT1

Front 29

Absorption of iron:

where are HCP1 located?

Back 29

located at the brush border of enterocytes

Front 30

Absorption of Iron:

non-heme iron existes in the ___ state

Back 30

Fe^3+ state

Front 31

absorption of iron:

non-heme iron is absorbed into the ___ by metal ion transporter ___

Back 31

enterocytes by metal ion transporter DMT1

Front 32

absorption of iron:
What vitamin forms a soluble complex; promoting absorption of nonheme iron

Back 32

vitamin C

Front 33

absorption of iron:

how is nonheme taken up?

Back 33

endocytosis

Front 34

Absorption of vitamin B12 :

low B12 retards what?

Back 34

maturation of RBC

Front 35

Absorption of vitamin B12 :

low B12 retards maturation of RBCs and results in ___

Back 35

pernicious anemia

Front 36

Absorption of B12:

__ is a B12 binding protein

Back 36

intrinsic factor

Front 37

Absorption of B12:

intrinsic factor is secreted by __- cells

Back 37

parietal cells

Front 38

Absorption of B12:

intrinsic factor binds with less affinity than ___

Back 38

R proteins

Front 39

Absorption of B12:

___ degrade R protein-B12 complex

Back 39

pancreatic proteases

Front 40

Absorption of B12:

free B12 binds to ___

Back 40

intrinsic factor

Front 41

Absorption of B12:

___ binds to complex ( R protein-B12 complex) and allows absorption (ileum)

Back 41

brush border receptor

Front 42

Absorption of B12:

only 1 to 2% of normal ingestion B12 is absorbed without ___

Back 42

Intrinsic factor

Front 43

absorption in the large intestine: formation of feces

___mL of chyme goes through the ileocecal valve into the large intestine

Back 43

1500mL

-100mL of fluid excreted

Front 44

absorption in the large intestine: formation of feces

water and electrolytes are absorbed

what is the absorbing colon?

Back 44

proximal

Front 45

absorption in the large intestine: formation of feces

water and electrolytes are absorbed

what is the storage colon?

Back 45

distal

Front 46

Secretions and absorption of the colon:

what cells in the colonic mucosa secrete mucus

Back 46

goblet cells

Front 47

Secretions and absorption of the colon:

goblet cells secretes HCO3 while simultaneously absorb___

Back 47

Cl

(which neutralizes acidic end products of bacterial action)

Front 48

Secretions and absorption of the colon:

Goblet cells are stimulated by __

Back 48

cholinergic agents

Front 49

substances formed as a result of bacterial activity in colon:
(7)
?

Back 49

vit K, vit B12, thiamine, riboflavin, various gases (carbon dioxide, hydrogen gas, methane)

Front 50

Composition of feces:

the brown color from derivatives of ___

Back 50

derivatives of bilirubin
which are :
stercobinin and urobilin

Front 51

composition of feces:

___ % is water and ___% solid material

Back 51

3/4 water 1/4 solid material

Front 52

Pathology of the intestine:

___ is also referred to as idiopathic steatorrhea

Back 52

Celia Sprue

Front 53

Pathology of the intestine:

celiac sprue is called __ in children

Back 53

celiac disease

Front 54

Pathology of the intestine:

in Celiac Sprue atrophy of villi of the small intestine is induced by ___

Back 54

gluten-containing foods (rye, oats, barley, and especially wheat)

Front 55

Pathology of the intestine:

Celiac Sprue results in ___

Back 55

malabsorption

Front 56

Pathology of the intestine:

what is induced by gluten-containing foods in Celiac Sprue

Back 56

atrophy of villi of Small intestine

Front 57

Pathology of the intestine:

What disease has these characteristics?

-regional enteritis
-most commonly the terminal ileaum
-an inflammatory disease etiology unknown
-produces symptoms outside GI

Back 57

Crohn's disease

Front 58

Pathology of the intestine:

what does chrohn's disease usually effect?

Back 58

terminal ileum

Front 59

Pathology of the intestine:

where is diverticular disease usually most commonly found?

Back 59

sigmoid colon

Front 60

Pathology of the intestine:

what is the main cause of diverticular disease?

Back 60

low-residue diet

Front 61

Pathology of the intestine:

___ is not inflammed diverticular

Back 61

diverticulosis

Front 62

Pathology of the intestine:

___ - inflamation of the diverticula

Back 62

diverticulitis

Front 63

Pathology of the intestine:

what is a result of small herniations of the mucosa and submucosa thru defects in the muscularis of the colon?

Back 63

diverticular disease

Front 64

Pathology of the intestine:

fecalith probably plays a role in this

Back 64

appendicitis

Front 65

Pathology of the intestine:

what is the 2nd most frequent cause of death from cancer in the us

Back 65

cancer of the colon and rectum

Front 66

Pathology of the intestine:

___ is described as a spherical head attached by a stalk

Back 66

pefunculated adenoma

Front 67

Pathology of the intestine:

polyps of the colon:

____- abnormal growth of a cell that should be granular

Back 67

pedunculated adenoma

extremely common (10% adults, 50% of those are >30)

Front 68

Pathology of the intestine:

polyps of the colon:

what begins as a papilla attached by a broad base?

Back 68

Villous adenoma

Front 69

Pathology of the intestine:

polyps of the colon:

what type of polyp of the colon is usually in rectosigmoid?

Back 69

villous adenoma

Front 70

Pathology of the intestine:

polyps of the colon:

what develops into a cauliflower like mass

Back 70

villous adenoma

Front 71

Pathology of the intestine:

polyps of the colon:

t/f

villous adenoma tend to undergo malignant transformation

Back 71

true

along with familial multiple polyposis of the colon

Front 72

Pathology of the intestine:

polyps of the colon:

familial multiple polyposis of the colon:

is usually ___ transmission

Back 72

autosomal dominant transmission