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26 Cards in this Set
- Front
- Back
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hyper uricemia
-causes? |
-over producers, diet, cell breakdown due to CA, under excretion
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purine broken down into?
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-uric acid
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crystal induced synovitis
-when attacks 1st MTP joint? |
-podagra
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crystals made of:
-gout? -pseudo gout? -calcific tendonitis? |
-urate
-calcium pyrophosphate dihydrate -apatite |
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NSAIDs
-mechanism? -toxicities? |
-comp. inhibit cyclooxygenase synthesis of prostaglandins involved in inflammation (pain, vasodilation, capillary perm.)
-nephropathy, gastropathy |
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glucocorticoids
-mechanism? |
-inhibits synth/release of inflamm. cytokines (Il-1, leucotrienes, PGE2); inhibits release of arachidonic acid
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glucocorticoids
-too much leads to? |
-abn. fat distribution, osteoporosis, wt. loss, hyper glycemia, insulin resistance, neg. N balance, immunosuppresion
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colchicine
-mechanism? |
-inhibits microtubules, inhitibt neutrophil chemotaxis, mobilty, phagocytosis, synthesis eicosanoids
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urate lowering therapies?
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-allopurinol, uricosurics
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colchicine
-toxicities? |
-diarrhea, vomiting, bone marrow suppresion, renal/hepatic toxicity
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anakinra
-mechanism? -side effects? |
-Il-1 receptor antagonist, alt. to colchicine
-injection site rx, immunosuppression, infections |
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treatment of:
-chronic gout? -acute gout? |
-diet, xanthine oxidase inhibitors, ,uricosuric drugs
-NSAIDs, glucocorticosteriods, colchicine |
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Drugs for tmt of acute gout/pseudogout?
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-NSAIDs
-glucocorticosteriods -colchicine |
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allopurinol
-type of drug? -mechanism? -side effects? |
-xanthine oxidase inhibitor
-inhibitor of urate synthesis (xan. oxidase is a catalyst) -rash, vasculitis, GI problems |
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pegliticase
-mechanism? -side effects? |
-urate oxidase enzyme
-IV ever 2 weeks, hypersensitivity |
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probenecid
-type of drug? -mechanism? |
-uricosuric
-inhibit urate reabsorption, or compete with urate secretion; dont take with aspririn |
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psuedo gout often affects which joints in hand?
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-carpals/ wrist
-MCP |
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RA often affects which joints in hand?
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-carpals/wrist
-MCP -PIP |
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OA often affects which joints in hands?
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-DIP
-PIP |
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-Bouchards node?
-Heberden's node? |
-PIP joint
-DIP joint |
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osteoarthritis
-most common tmt? |
-NSAIDs
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rheumatiod arthritis
-definition? -affects? -signs? |
-AI disorder, joint pain, polyarticular, inflammatory, additive, symmetrical, peripheral
-small joints of hands/feet -boutonneire contracture, swan neck deformity |
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RA drugs?
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-hydroxychloroquine, prednisone, azathioprine
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methotrexate
-type of drug? |
-purine inhibitor
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infliximab
-type of drug? -side effects? |
-anti-TNFa agent
-infection, malignancies |
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cyclosporine A
-type of drug? -alternatives? -side effects? |
-inhibitor of calcineurin
-tarolimus, sirolimis -nephrotoxic |
