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46 Cards in this Set
- Front
- Back
lysosomes
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digest enzymes
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mitochondria
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energy
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ribosomes
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protein
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endoplasmic reticulum
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protein synthesis/enzymatic reactions, stores Ca2+
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golgi complex
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recieves from endoplasmic reticulum, modifies, and releases
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what type of molecule can freely pass through a plasma cell membrane?
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small, nonpolar, neutrally charged molecules
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carrier mediated transport is broken into ....
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1. facilitated diffusion
2. active transport |
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carrier-mediated transport is broken into ....
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1. active transport
2. passive transport (faciltiated diffusion) |
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explain passive transport
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net movement across a membrane
no atp higher conc. to lower conc. |
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explain active transport
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net movement against the conc. gradient
requires apt lower conc. to higher conc. |
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the rate of diffusion is effected by
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1. magnitude
2. permeability 3. surface area 4. temperature 5. distance |
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osmosis can only be determined if
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1. there is a difference in concentrations across a membrane
2. membrane must be impermeable to a solute |
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aquaporins
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cells that allow water to pass rapidly
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carrier mediated transport characteristics
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1. specificity
2. saturation 3. competition |
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active transport breaks into ...
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1. primary active transport
2. secondary active transport |
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primary active transport steps
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1. solute binds to carrier
2. hydrolysis of ATP, results in phosphorlyation of carrier 3. conformational (shape) change 4. exposes solute to other side of membrane |
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Na+/K+ pump steps
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1. 3 Na+ bind
2. ATP ---> ADP + Pi 3. ADP releases, conformation change (Na+ exits) 4. 2 K+ ions bind to Pi 5. conformation change back PROVIDES ENERGY FOR SECONDARY ACTIVE TRANSPORT |
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describe secondary active transport
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uses ATP indirectly
drives solutes up conc. gradient |
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cotransport
countertransport |
symport, solutes in same direction
antiport, solutes in opposite direction |
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describe membrane potential
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occurs naturally
difference in charge across a membrane |
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describe equillibrium potential
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Ex
voltage across membrane -potential needed to maintain conc. gradient inside/outside of the cell |
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describe resting membrane potential
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RMP
membrane voltage ranges from -65 mV to -85 mV dependent on ion concentration in/out of cell |
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electrogenic effect is caused by ...
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3 Na+ leaving
2 K+ entering |
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describe schwann cells
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form meyelin sheath
wraps axons in PNS support cell 1 mm in width (fade >3mm away) many needed to cover the axon |
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neurilemma
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schwann cell cytoplasm
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describe satellite cells
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support neuron bodies
metabolic exchanges electrical insulators |
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describe oligodendrocytes
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large cells
form meyelin sheath around axons in CNS produces white matter |
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describe microglia
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small cell
phagocytic (eats things) proliferates (produce, multiply, divide) monocytic blood --> brain |
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describe ependymal cells
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cuboidal, single layer of lining cell
line cavities cilia beats & circulates CSF microvilli increases surface area |
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describe astrocytes
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large, star-shaped cell
~50% neural tissue braces neurons, holds into place, hang onto capillaries end feet - wrap tightly to capillaries forms bbb |
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all brain tumors are ...
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neuroglial
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describe ion gating
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1. stimulus causing rmp to change, causing depolarization
2. depol. threshold levels causes sodium channels to open 3. inactivation process causes sodium channels to close; depol. stimulus causes potassium channels to open 4. potassium channels close and membrane potention reaches rmp |
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na+/k+ are stimulated by depolarization, so they are ....
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voltage gated channels
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describe action potential
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1. stimulus, strong enough to reach -55 mV
2. activates/inactivates Na+ gates 3. depolarizes the cell 4. rapidly reduces Na+ permeability 5. Activate K+ channels, repolarization stage 6. slow to close, hyperpolarization stage 7. resets to RMP, can become stimulated again |
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"all or none" means
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the amplitude (size) of action potentials
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inactivation ..
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occurs automatically
lasts until the membrane repolarizes |
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describe coding
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frequently modulated (FM)
recruitment: when the intensity of a stimulation increases, more and more axons become activated |
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describve absolute refactory period
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during an action potential, the axon is incapable of responding to another stimulus
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describe relative refactory period
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when the axon can be stimulated by only a very strong stimulus
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depolarization stimulus is when
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na channels are closing
k channels are opening |
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describe cable properties
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ability to conduct charges thru a neurons cytoplasm
high internal resistance (poor conduction) |
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saltatory conduction
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"leaping" from nodes of ranvier
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describe gap junctions
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allow action potentials to spread from cell to cell
composted of 12 proteins (connexin) passage of Ca2+ can be closed or opened |
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a synapse allows
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functional junction between cells
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describe the steps of the synapse in teh presynaptic neuron
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1. action potential arrives, stimulates ion
2. Ca2+, outside cell 3. open channel, Ca2+ rushes into the cell 4. Ca2+ binds to sensor protein, forms COMPLEX 5. complex stimulates the fusion of vesicles --> membrane |
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the synaptic cleft is ...
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the sapce between the presynaptic / postsynaptic axon
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