Weak Stuff To Hit Hard

Front 1

Lesch-Nyhan syndrome

Back 1

Defective purine salvage owing to absence of HGPRT (converts hypoxanthine to IMP and guanine to GMP). Results in excess uric acid productions. Findings: retardation, self-mutilation, aggression, hyperuricemia, gout, choreoathetosis

Front 2

Cystinuria

Back 2

Hereditary defect (AR) of renal tubular amino acid transporter for cysteine, ornithine, lysine, and arginine in PCT. Leads to precipitation of cystine kidney stones.

Front 3

Actions of ALDOSTERONE

Back 3

1) increases Na+-H+ transporters in DCT and collecting tubes - increase Na+ absorption 2) increase K+ secretion 3) Increase renal H+ secretion (alpha-intercalated cells)

Front 4

Actions of PTH

Back 4

1) Increase bone reabsorption 2) Decrease phosphate reabsorption at PCT 3) Increase Ca+/Na+ exchange in distal tubule 4) Increase intestinal Ca++ absorption indirectly by stimulation prod of 1,25 OH Vit D.

Front 5

Actions of ATII

Back 5

1) Increase BP by acting on AT II receptors on vascular SM 2) Constrict efferent arterioles of glomerulus 3) Increase aldosterone prod. 4) Increase prox. tubule Na+/H+ activity 5) Increase ADH secretion. 6) Stimulate hypothalamus --> thirst

Front 6

Actions of ANP

Back 6

1) relax vascular SM 2) Increase excretion of Na+ and H20 in kidney by increasing GFR and Na+ filtration w/ no compensatory Na+ reabsorption in distal nephron

Front 7

Actions of CORTISOL

Back 7

1. Anti-inflammatory
2. Increase gluconeogenesis, lipolysis, and proteolysis
3. Decrease immune function
4. Maintain blood pressure
5. Decrease bone formation

Front 8

von Hippel-Lindau syndrome

Back 8

(AD) Cavernous hemangiomas in cerebellum and retina. Increased incidence of pheochromocytoma and bilateral renal cell carcinomas