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51 Cards in this Set
- Front
- Back
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differention betwn male and female during development
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androgen drive
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nerve cell that oversees spermatogenesis
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sertoli cells
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cells that secrete steroids
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leydig/interstitial
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C18
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testerone
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C21
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progesterone and glucocorticoids
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C19
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androgen
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weak bioactive form of testerone
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delta 4
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strong bioactive form
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delta 5
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Rate Limiting step for synthesis of DHT
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SSC (side shain cleavage enzyme
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Enzymes for the diff steps
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pregnenolone to DHEA
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3B-OH-steroid DH
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DHEA to androstenediol
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17B-OH-steroid DH
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androstenediol to androsterone
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5 alpha reductase
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androstenediol to testosterone
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3B-OH-steroid DH
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testosterone to DHT
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5 alpha reductase
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testosterone to E2
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CYP 19 aromotase
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E1 to E2 also goes back to E1
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17B
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E2
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estradiol
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at about what age is sperm prod at its highest
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17- 62 Adult age
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% of testosterone bound to sex hormone binding globulin
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45%
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% of testosterone bound to albumin and corticosteroid- binding globulin
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55%
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% free T- most imp biologically
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2%
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Metabolism of T: in liver
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17-ketosteroids
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1 spermatocyte to 2 spermatocyte takes 19 days
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meiosis 1
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2 spermatocyte to 4 spermatids takes 19 days
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meiosis 2
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4 spermatids to mature sperm takes 21 days
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differention
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when does spermatogonia occur in males
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after puberty
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amt of testosterone in semen that is considered to be infertile
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< 20 million
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what determines the devp of genital organs and characteristics
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testosterone
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final pH of semen
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7.5
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whose muscles are bigger desmonda or jimmy? What is weird about that
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desmonda, because men should have more testosterone meaning they should have more muscles
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functions of DHT
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fetal devp of penis, penile urethra, scrotum, prostate, prostatic secretion and pubertal growth of scrotum, prostate, sexual hair and sebaceous glands
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what causes testicular feminization
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deficiency in androgen receptors
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what is a func of testosterone which may lead to coronary heart disease
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inc in LDL and decrease in HDL
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which system controlls the male erection
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PS
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procedure when a small segment of vas deferens is removed
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vasectomy
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does this procedure effect the sexual response
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no
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2 causes of premature ejaculation
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anxiety and learned beh
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indicator of carcinoma of the prostatrate (Gant)
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PSA prostate spec antigen
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what can cause a false pos on the PSA
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infl of prostate
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What diseases cause premature ejaculation
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DM, hypotension, hypothyroidism/hyperprolactnnemia, red HDL
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what stressors can cause prematue ejaculation
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unemployment and performance anxiety
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2 diseases caused dihydrotestosterone
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male pattern baldness and benign prostatic hypertrophy
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how would you tx these two disorders
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finasteride- 5 alpha reductase inh
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how would you tx cancer of the prostate flutamide- androgen rec antagonist
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Contraindication to prescribing meds for ED
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recent MI, stroke, retinal pigmentosa, patient taking alpha blockers
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these enzymes are always found in cGMP which is also a target for the ED drugs
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phosphodiesterase, PDE-5 inh
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what age does testosterone start to decrease-andropause
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40
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had LH or FSH changed in aging men
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LH no, FSH yes
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should you give testosterone supplements: is it beneficial?
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well in aging men you usually get hypertrophy
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Klinefelter Syndrome
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short, small penis lack of facial hair, 47XXY, sterile and gynecomastia
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