Warren Lecture 1

Front 1

What are the 3 Functions of the Plasma Membrane?

Back 1

1) Control internal environment
2) Integral proteins anchor cytoskeleton and cell attachment
3) Receptors that receive signals and regular cell behavior

Front 2

What are the major components of the plasma membrane?

Back 2

1) Phospholipid bilayer
2) Integral and peripheral membrane proteins
3) Carbohydrates (oligosaccharides)

Front 3

What do carbohydrates on membrane do?

Back 3

1) Help define cell identity
2) Bind to extracellular elements
3) Protect external surface of cell

Front 4

What phospholipids make up the membrane?

Back 4

1) Glycerophospholipids
2) Sphingomyelin

Front 5

Why aren't extra-chain disulfide bonds found on cytoplasmic domains of integral proteins?

Back 5

Only free sulfhydryl groups are found because cytoplasm is a reducing environment, though interchain disulfide bonds are important for domain structure.

Front 6

Name 3 examples of peripheral membrane proteins

Back 6

1) Cytoskeletal
2) Signal transduction
3) Extra-cellular matrix proteins

Front 7

Name 5 metabolic activities in the cytoplasm.

Back 7

1) Glycolysis 2) Fatty acid synthesis 3) protein synthesis 4) proteolysis 5) maintenance of a reducing environment

Front 8

What is the difference b/n Rough and Smooth ER?

Back 8

Rough - contains pore elements for attachment of ribosomes that are synthesizing proteins and importing proteins as made; enzymes fo rfurther protein processing
Smooth - Lacks pore/docking sites but:
1) Synthesis of phospholipids, glycolipids, cholesterol and other steroids
2) Mobilization of glucose from glycogen
3) Detoxification of drugs
4) uptake of Ca++

Front 9

What do peroxisomes do?

Back 9

Beta oxidation of fatty acids (though in hepatocytes they share this function with mitochondria)

Front 10

What is heteroplasmy?

Back 10

The co-existence of normal and mutant mtDNA in a cell