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35 Cards in this Set
- Front
- Back
first myopathy in which a single enzyme defect was identified=
And so what were these individuals lacking? what about the organs of the these people? |
McArdles Disease
muscle phosphorylase- which is responsible for the break down of glycogen in the muscle. (these people also cant produce lactic acid) they arent effected, its limited to muscle, and they learn to adapt to their routine. |
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infantile form of AMD-
AMD is an uncommon glycogen storage disease elaborate.... |
pompe disease (enlarged heart, hypotonia... due to increase glycogen stores)
is associated with accumulation of glycogen in the lysosomes of muscle cells and cells of other tissues. |
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infections of varying severity are known to produce ______ changes in muscle. Umbrella term =
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inflammatory changes
Myositis |
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___ is believed to regulate muscle protein synthesis and electroylte balance=
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thyroid hormone (from endocrine system)
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____ and ____ are the most common muscle inflammatory diseases requiring long term care.
____ plays a key role in their symptom manafestation ? |
poly and dermatomyositis
cytokinens fyi- Derm.. is worse because more vascular involvement is involed |
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malignant tumor of striated muscle=
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rhabdomyosarcome
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What is Osteomyelitis
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a bone infectino caused by most often by bacteria (staph)
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what is the most serious musculoskeletal injury?
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fracture
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is bone tissue normally mineralized in osteoperosis?
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YES! but the density is reduced because the bone remodeling cycle is disrupted
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What is a disease with inadequate bone mineralization?
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osteomalacia
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myelogenic=
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vascular marrow cell
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3 ways Non inflammamatory joint disease is different from inflammatory jd?
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1. synovial membrane isnt inflammed
2. no systemic signs or symptoms 3. presence of normal synovial fluid |
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pathalogic muscle contracture=
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PERMANENT shoertening caused by muscle spasticity as seen in CNS injury or severe muscle weakness
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when does bone formation begin?
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8th week of gestation
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DDH=
which hip is most effected |
abnormality in the development of the proximal femur, acetabulum or both
60% left hip |
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osteomyelitis occurs most often in what age range?
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3-12 (more in males)
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endochondrial formation-
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bone cells multpyply on epipyesal plate, and distroyed and replaced on metaphyseal plate
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Risk factors for DDH=
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1. female
2. breech birth 3. first pregnancy 4. family history |
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JV RA facts
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1. large joints affected
2. aks and subluxation common 3. less pain then adult 4. detect antinuclear body |
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what pain in the knee disease is most common in males at age 6?
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Leg Clave perth
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most common bone tumor during childhood-
most common soft tissue disorder? |
osteosarcoma
rhabdomyosarcoma |
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Galeazzi sign=
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leg length descrepency
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torus fracture=
bowing fractures= |
bone buckles but doesnt break
occur with longitudinal force |
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tennis elbow=
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lateral epicondylitis
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complications of Rhabdomyelotis
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1. muscle spasms/ rigidity
2. renal failure 3. hyperthermia 4. cardiac arrythmia 5. both acidosis 6. edema/ shock |
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complications of pagets disease
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1. thick skull
2. CN disfucntion 3. impaired motor function 4. obstructed lacimal duct 5. deafness, atrophy |
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what age group has the highest incidence for bone tumors?
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adolescents. (30's have the loweset incidence)
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what disease do you see clubbing in the fingers?
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1. cystic fibrosis
2. bronchiectasis 3. pulmonary fibrosis 4. lung abcess 5. congenital heart disease |
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____ is most common in children and caused by a virus
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bronchiectasis
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pus in the pleural space-
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empynea.... an abcess is NOT pus, its distruction of paraynchmia
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what disease is associated with cough, dyspnea and asbetos?
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pulmonary fibrosis
(NOT pneumonia) |
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most common cause of ards=
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sepsis or multiple trauma
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what qualifies chronic bronchitis?
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at least 3 months and 2 consecutive years
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what disease will manafest from alpha antitrypsin deficiancy?
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emphazema
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what virus is associated with cooling/water systems?
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legonella
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