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35 Cards in this Set

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first myopathy in which a single enzyme defect was identified=

And so what were these individuals lacking?

what about the organs of the these people?
McArdles Disease

muscle phosphorylase- which is responsible for the break down of glycogen in the muscle. (these people also cant produce lactic acid)

they arent effected, its limited to muscle, and they learn to adapt to their routine.
infantile form of AMD-

AMD is an uncommon glycogen storage disease elaborate....
pompe disease (enlarged heart, hypotonia... due to increase glycogen stores)

is associated with accumulation of glycogen in the lysosomes of muscle cells and cells of other tissues.
infections of varying severity are known to produce ______ changes in muscle. Umbrella term =
inflammatory changes
Myositis
___ is believed to regulate muscle protein synthesis and electroylte balance=
thyroid hormone (from endocrine system)
____ and ____ are the most common muscle inflammatory diseases requiring long term care.

____ plays a key role in their symptom manafestation ?
poly and dermatomyositis

cytokinens

fyi- Derm.. is worse because more vascular involvement is involed
malignant tumor of striated muscle=
rhabdomyosarcome
What is Osteomyelitis
a bone infectino caused by most often by bacteria (staph)
what is the most serious musculoskeletal injury?
fracture
is bone tissue normally mineralized in osteoperosis?
YES! but the density is reduced because the bone remodeling cycle is disrupted
What is a disease with inadequate bone mineralization?
osteomalacia
myelogenic=
vascular marrow cell
3 ways Non inflammamatory joint disease is different from inflammatory jd?
1. synovial membrane isnt inflammed
2. no systemic signs or symptoms
3. presence of normal synovial fluid
pathalogic muscle contracture=
PERMANENT shoertening caused by muscle spasticity as seen in CNS injury or severe muscle weakness
when does bone formation begin?
8th week of gestation
DDH=

which hip is most effected
abnormality in the development of the proximal femur, acetabulum or both

60% left hip
osteomyelitis occurs most often in what age range?
3-12 (more in males)
endochondrial formation-
bone cells multpyply on epipyesal plate, and distroyed and replaced on metaphyseal plate
Risk factors for DDH=
1. female
2. breech birth
3. first pregnancy
4. family history
JV RA facts
1. large joints affected
2. aks and subluxation common
3. less pain then adult
4. detect antinuclear body
what pain in the knee disease is most common in males at age 6?
Leg Clave perth
most common bone tumor during childhood-

most common soft tissue disorder?
osteosarcoma

rhabdomyosarcoma
Galeazzi sign=
leg length descrepency
torus fracture=

bowing fractures=
bone buckles but doesnt break

occur with longitudinal force
tennis elbow=
lateral epicondylitis
complications of Rhabdomyelotis
1. muscle spasms/ rigidity
2. renal failure
3. hyperthermia
4. cardiac arrythmia
5. both acidosis
6. edema/ shock
complications of pagets disease
1. thick skull
2. CN disfucntion
3. impaired motor function
4. obstructed lacimal duct
5. deafness, atrophy
what age group has the highest incidence for bone tumors?
adolescents. (30's have the loweset incidence)
what disease do you see clubbing in the fingers?
1. cystic fibrosis
2. bronchiectasis
3. pulmonary fibrosis
4. lung abcess
5. congenital heart disease
____ is most common in children and caused by a virus
bronchiectasis
pus in the pleural space-
empynea.... an abcess is NOT pus, its distruction of paraynchmia
what disease is associated with cough, dyspnea and asbetos?
pulmonary fibrosis

(NOT pneumonia)
most common cause of ards=
sepsis or multiple trauma
what qualifies chronic bronchitis?
at least 3 months and 2 consecutive years
what disease will manafest from alpha antitrypsin deficiancy?
emphazema
what virus is associated with cooling/water systems?
legonella