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411 Cards in this Set

  • Front
  • Back

How often does the carbon dioxide absorbent canister need to be changed?

Every 6-8 hours of use

Passive scavenging systems use ___________________________ to nullify the harmful gases

Canister of activated charcoal

Active scavenging systems use ________________________ to draw out waste gases

Vacuum

Rebreathers (circle systems)

Expired gases are mixed in with the fresh incoming gas and oxygen to be inhaled by the patient. They also retain heat for patient warmth

Non-rebreathers (Bain systems)

Rely on high gas flow to flush carbon dioxide into the scavenger system. Higher gas flow promotes hypothermia and the high consumption of gas is expensive to use

Which stage of anesthesia is the "excitement phase"

Stage 2

Propofol

- Rapid acting


- Quickly eliminated from the body by hepatic and extrahepatic metabolism


- Potent respiratory depressant that can cause apnea after induction


- Can cause hypotension due to vasodilation


- Does cross placental barrier but with minimal depressant effects on the fetus


- IV administration only

Etomidate

- Rapid acting


- Produces a hypnotic-like state that doesn't completely sedate, therefore induction can be rough


- Eliminated by hepatic metabolism


- Administration can be painful due to propelyne glycol carrier


- Cardiovascular system is unaffected by this drug


- Does cross placental barrier, but with minimal depressant effects on fetus.


- IV administration only

Benzodiazapines

- Diazepam, midazolam, and zolazepam


- Reduce anxiety and provide skeletal muscle relaxation


- Given with another induction agent because they do not provide sedation and may cause excitement


- Eliminated by hepatic metabolism

Diazepam

Contains propylene glycol which can be irritating to the tissues and causes the drug to have an unreliable absorption rate when given intramuscularly.




Not water soluble and can only be mixed in a syringe with ketamine

Zolazepam

Benzodiazepine in mixture of Telazol

Cyclohexamines

- Ketamine and Tiletamine


- Stimulate the CNS rather than depress it like most other induction drugs


- Produces muscle rigidity and sensitivity to light, sound, and touch.


- Increases heart rate, blood pressure and intraocular pressure


- Recovery can be rough as patients tend to be dysphoric

Ketamine

- Metabolized by the liver in the dog and kidney in the cat

Tiletamine

Cyclohexamine part of the mixure Telazol

Barbiturates

- Thiopental and methohexital


- Rapid onset of action


- Causes respiratory and cardiovascular depression


- Metabolized hepatically and extrahepatically


- Redistributes to highly lipid areas of the body


- Contraindicated for cesareans, cardiac dz, hepatic dz, respiratory dz, hypoproteinemia, acidosis, or hypothermia

Thiopental

Cumulative effect with repeated doses

Methohexital

Does not have cumulative effect and does not redistribute to highly lipid tissues as heavily as thiopental does

ECG (Electrocardiogram)

- Avisual representation of heart conduction and provides a heart rate.


- Allowsyou to assess heart rhythm, electrical conduction though the heart, andidentify arrhythmia’s


- Disadvantage:Does not indicate cardiac function and can look normal even though peripheralblood pressure is compromised

SpO2 - Pulse Oximetry

- Measures the oxygen saturation in blood and gives a pulse rate.


- Provides a visual pulse waveform.


- Disadvantage: Has to be moved frequently due to capillary’s being crushed by the monitoring device. Unreliable at low saturation levels and difficult to get a reading if tissue has dark pigmentation.

Capnography

- Measures the endtidal and inspiratory carbon dioxide and anesthetic gas concentration.

- Endtidal CO2 readings are 5-10 mm Hg lower than actual alveolar concentrations.


- Allows you to access systematic metabolism, cardiac output, pulmonary perfusion, and the adequacy of patient ventilation

CVP (Central Venous Pressure)

- Indicatesfluid status and assesses cardiac output.


- Normalrange:


0-4 cm H2O – standing, awake


2-7 cm H2O anesthetized.


- Higher readings thannormal indicate hypervolemia or myocardial depression/heart failure and lower readingsindicate hypovolemia

Blood Gas Values

- Givesand accurate representation of the respiratory function and acid-base balance


- Mustbe taken from an artery to evaluate respiratory function.


Normal values for anarterial blood gas:


PH – 7.35 – 7.45


PaCO2 – 35-45 mm Hg,


PsO2 90-115 mm Hg onroom air, if the patient is on 100% oxygen the PsO2 = 500 mm Hg, SaO2 ->95%, HCO3 - 18-26 mEq/L, BE- -2 to+2

Pale mucus membranes

Vasoconstriction, decreased cardiac output, hypoxia, and anemia

Dark pink mucus membranes

Vasodilation, sludging of the blood in the capillaries, and high CO2 levels

Cyanotic mucus membranes

Severe hypoxemia

Yellow mucus membranes

High serum bilirubin from hemolysis or hepatic disease

Tachypnea

- Rabid breathing


- Caused by light anesthetic plane, pain, hypercarnia, hypovolemia, hypoxemia, drugs and cerebral spinal fluid acidosis

Apnea

- Suspension of breathing


- Caused by deep anesthetic plane, hypothermia, recent hyperventiliation, musculoskeletal paralysis and drugs.

Tachycardia

- Rapid heart rate


- Caused by light anesthetic plane, pain, hypotension, hypoxemia, hypercarbia, ischemia, acute anaphylactic reaction, anemia, and drugs

Bradycardia

- Slow heart rate


- Caused by deep anesthetic plane, hypertension, increased intracranial pressure, surgical vagal reflex, hypothermia, hyperkalemia, myocardial ischemia and drugs

Hypertension

- High blood pressure


- Caused by ligh anesthetic plane, pain, hypercarbia, fever and drugs



Hypotension

- Low blood pressure


- Caused by deep anesthetic plane, hypovolemia, sepsis, shock and drugs



Toxic foods to birds

Avocados - cadiac toxin that causes heart failure


Chocolate - seizures, vomiting, diarrhea, cardiac arrhythmias


Comfrey - causes liver damage


Avoid foods in high sugar and salt

Dermatologic Diseases : Birds

- Flies


- Lice, ticks, mites


- Ulceration or folliculites associated with bacterial infection


- Stress bars in feathers could indicate poor husbandry, infections or self-mutilation

Gastrointestinal Diseases: Birds

- Normal droppings contain both feces and urine, which comes from the cloaca


- Swollen crop, may be infectious: trichomonas (parasite), candida (fungus), or bacterial


- Viral, proventricular dilatation disease (PDD) associated with avian bornavirus: infection causes nervous system inflammation leading to neurologic signs and gastrointestinal dysfunction


- Tapeworm, giardia, roundworms

Respiratory Disease : Birds

Aspergillosis:fungal infection of the respiratory tract; may lead to fungal granulomas in theupper or lower respiratory tract

Viral Disease: Birds

- Psittacine beak and feather disease

- Polyoma virus


- Pacheco’s disease: parrot herpesvirus, often fatal

Zoonotic Diseases: Birds

- Chlamydophila psittaci (Psittacosis): one of most common bacterial respiratory diseases in pet birds. Transmission through inhalation or ingestion of spore-like phase of organism


- Exotic Newcastle disease: transmission through direct contact with viral particles from aerosolized bodily fluids; may result in systemic clinical signs in birds. In humans, can result in sinusitis, lethargy, and conjunctivitis


- West Nile virus: transmission through infected mosquitoes; causes neurologic disease in animals and people


- Avian influenza: wild birds are the natural hosts of Influenza A; different subtypes of influenza A have infected people. Dangerous subtypes identified = H5 & H7. Infection can result in flu-like symptoms and death in animals and people

Detrusor Muscle

Contracts during urination

Hypogastric nerve is part of the ____________________ in bladder intervention

Efferent sympathetic

Function of the hypogastric nerve

When stimulated, causes relaxation of detrusor, contraction of trigone and internal sphincter resulting in retention of urine

Pelvic nerve is part of the ____________________ in bladder intervention

Efferent parasympathetic

Function of the pelvic nerve

When stimulated, causes detrusor contraction andrelaxation of trigone and internal sphincter resulting in emptying of thebladder

The Pudental nerve is part of the _______________ in bladder intervention

Somatic

The Hypogastric and pelvic nerves are both part of the _____________, giving sensation due to bladder distension

Sensory (afferent)

How does the front cerebral cortex control micturition?

Conscious micturition

How does the thalamus control micturition?

Conditioned micturition

How does the brainstem control micturition?

Coordination of micturition

How does the sympathetic nervous system control micturition?

Controls storage phase

How does the parasympathetic nervous system control micturition?

Controls voiding phase


(Pelvic nerve)

How does the somatic nervous system control micturition?

Controls Pudendal nerve

How does the α-adrenergic stimulation (via hypogastric nerve) help in storing urine?

Maintainsinternal urethral sphincter contraction

How does the β-adrenergicstimulation help in storing urine?

Inhibitsdetrusor contraction, allowing filling

In blood gas analysis, what is normal pH?

7.35 - 7.45

In blood gas analysis, what is normal pCO2?

34 - 40

(Normal Venous Value is 38- 45)



In blood gas analysis, what is normal pO2?

80 - 120


(Normal Venous Value 45 - 65)

In blood gas analysis, what is normal HCO3?

18 - 24

In blood gas analysis, what is normal base excess?

-6 to +1

In blood gas analysis: pH is low, and HCO3 is low

Metabolic acidosis

In blood gas analysis: pH is low, and pCO2 is high

Respiratory acidosis

In blood gas analysis: pH is high, and HCO3 is high

Metabolic alkalosis

In blood gas analysis: if pH is high, and pCO2 is low

Respiratory alkalosis


If the patient is hyperventilating, what blood gas value is affected?

Low pCO2

If the patient is hypoventilating, what blood gas value is affected?

High pCO2

Function of cerebrum

Conscious thought and perception, largest partof the brain

Function of cerebellum

Motor control, coordinates movement

Function of the cerebellum

Motor control, coordinates movement

The diencephalon is composed of

Thalamus, hypothalamus, pituitary

Function of the hypothalamus

Controls temperature, thirst, hunger, sleep. Regulates neuroendocrine function and homeostasis of the body

Function of the Pituitary

Endocrine gland which secretes ACTH, TSH, growth hormone, prolactin, LH, FSH

Function of the Brain Stem

Connects the brain to the spinal cord. Origin of most cranial nerves. Composed of medulla oblongata, pons and midbrain

What are meninges?

Cover the brain and spinal cord

Dura Mater

Outer layer of meninges

Arachnoid

Middle layer of meninges

Pia mater

Inner layer of meninges

Cerebrospinal fluid

Flows between layers of meninges and protects/provides cushion for the brain

The periphreal nervous system is composed of

12 cranial nerves and 31 spinal nerves

The blood-brain barrier

Separates circulating blood from the fluid in the CNS - prevents toxins from getting to brain

Glial cells

Do not transmit nerve impulses but function tohelp protect the nervous system


(Oligodendrocytes in CNS and Schwann cells in PNS)

Body of neuron

Soma

What happens when sympathetic nervous system is stimulated?

Epineephrine is released and causes increased heart rate, increased blood pressure, pupil dilation(mydriasis), increase respirations, bronchodilation, and decreasedgastrointestinal activity. Can be triggered by fear, stress, excitement,exercise,etc

Neurotransmitters in the sympathetic nervous system

Adrenergic/catecholamine/epinephrine

What stimulates the parasympathetic nervous system?

Controls normal homeostasis. Acetylcholine isreleased in a rested state causing decreased heart and respiratory rate, pupilconstrition (miosis), increased salivation and gastrointestinal activity.(SLUD)- salivation, lacrimation, urination, defecation

Neurotransmitters in the parasympathetic nervous system

Cholinergic/acetylcholine

Parasympathetic nervous system and the sympathetic nervous system are both a part of

The autonomic nervous system

Communication between cells

Cellscommunicate via the Sodium-Potassium Pump. Sodium moves out of the cell andPotassium goes back into the cell




AtRest (Resting Membrane Potential): The cell is negative on the inside (K+) andpositive on the outside (Na+). This causes a charge across the cell membrane.




Firingof the cell is Depolarization. Sodium channels open and sodiumflows into the cell (now the cell is positive- “action potential”).




Repolarizationoccurs when the sodium channels close and potassium channels open. Nowpotassium is moved back into the cell and sodium is pushed out. The cell holdsa negative charge again

Key signs of canine parvovirus

Bloody diarrhea, vomiting, intussusception, leukopenia

How is parvo spread?

fecal-oral route

What does parvo do to the body?

Destroys rapidly dividing cells in intestinal crypts causing secondary villous atrophy

Treatment for parvo?

None, only supportive care

Supportive care for parvo?

IV fluids, with electolyte deficit of patient




Antibiotics - either amikacin and potentiated clavulanic acid OR enrofloxacin and ampicillin/cefazolin/metronidazole




Anti-emitics - metoclopramide, chlorpromazine or maropitant (Cerenia)




Gastric protectants - Ranitidine, omeprazole, sucralfate

Function of the vena cava?

bringsde-oxygenated blood from the body to the heart and empties into the rightatrium

Function of the aorta

Largest vessel in body and carries oxygenated blood from the left ventricle

Function of the pulmonary artery

transports the de-oxygenated blood from the right ventricle to the lungs

Function of the pulmonary vein

transports oxygenated blood from the lungs to the left atrium

Function of the coronary arteries

branch off of the aorta near the top of the heart and carry oxygen to the cardiac muscle tissue

Chambers of the Heart

Left atrium, left ventricle, right atrium and right ventricle

Left atrium

Receives oxygenated blood from the lungs via the pulmonary vein. During contraction, blood passes from the left atrium through the mitral valve into the left ventricle

Left Ventricle

Receives oxygenated blood from the left atrium during contraction. As the blood goes through the mitral valve and into the left ventricle, the aortic valve is closed so that the ventricle may fill. After the ventricles are full, they contract. During contraction, the mitral valve closes to prevent backflow of blood and the aortic valve opens to allow the blood to go into the aorta and out to the body

Right Atrium

Receives de-oxygenated blood from the body via the vena cava. During contraction blood passes from the right atrium through the tricuspid valve and into the right ventricle

Right Ventricle

Receives de-oxygenated blood from the right atrium during contraction. As the blood goes through the tricuspid valve and into the right ventricle, the pulmonary valve is closed so that the ventricle may fill. During contraction, the tricuspid valve closes to prevent backflow and the pulmonary valve opens so that blood goes into the pulmonary artery and to the lungs

Mitral Valve

separates left atrium from left ventricle

Tricuspid Valve

separates right atrium from right ventricle n

Pulmonary Valve

separates right ventricle from the pulmonary artery

Aortic Valve

separates left ventricle from the aorta

Chordae tendinae

tendons which link the papillary muscles to the valves and aid in opening and closing of the valves. String-like in appearance

Papillary muscles

contract to open the valves. Connected to chordae tendinae

Systole

During systole, blood is ejected from the ventricles into the arteries leaving the heart. The left ventricle empties into the aorta and the right ventricle empties into the pulmonary artery. The pressure created during this contraction is called systolic pressure

Diastole

Diastole occurs when the ventricles are relaxed. During this time the ventricles are filling with blood, preparing for the next contraction

Sinoatrial Node (SA Node)

The natural pacemaker of the heart. It starts the electrical impulses in the heart, which then travel to the Atrioventricular node (AV node)

Atrioventricular Valve (AV Node)

The AV node delays the impulse until theventricles are completely filled. The impulses pass from the AV node throughthe right and left bundle branches (at the Bundle of His)

Bundle of His


Sends impulses to cause cardiac contraction

Purkinje fibers

Purkinje fibers are specialized cardiac musclecells that conduct impulses deep within the myocardium assisting to transmitimpulses from the AV node to the ventricles

Dilated Cardiomyopathy (DCM)

Weakened and enlarged heart; may be associated with taurine deficiency in some cases
Hypertrophic Cariomyopathy (HCM)
Hypertrophy or thickening of the myocardium (heart muscle); sometimes associated with hyperthyroidism in cats

CongestiveHeart Failure (CHF)

Heart can no longer pump blood efficiently and leads to pulmonary edema (fluid in the lungs)

Second-degree AV block

Common in horses; Arrhythmia causing delay at the AV node, often caused by high vagal tone in athletically fit horses, may resolve with exercise. May see a p wave with no QRS on an ECG

Ventricularfibrillation (V-fib)

Uncoordinated contraction of the cardiac muscle in the ventricles. It is during V-fib that a defibrillator may be used to try and induce back to a normal rhythm

Furosemide (Lasix)

A loop diuretic used in congestive heart failure. (side note: diuretics increase urination)

Spironolactone

An aldosterone antagonist used as a potassium sparing diuretic

Enalapril

An ace inhibitor/ vasodilator used often inconjunction with a diuretic for treating CHF

Pimobendan

Inodilator used in treatment of CHF in dogs withCHF from valvular disease or from DCM

Atropine

Anticholinergic, given to increase heart rate, often during anesthesia or during arrest

Nitroglycerine

Potent venodilator, often used in acute CHF as atopical (must wear gloves)

Sildenafil (Viagra)

Used mostly in vet med for treating pulmonary hypertension

Lidocaine

Used to treat ventricular tachycardia and VPC’s (ventricular premature contractions)

Digoxin

Cardiac glycoside, blood levels should be monitored to preventtoxicity

Warning signs of impending cardiopulmonary arrest

Alterations in respiratory rate, respiratory character, hypotension, bradycardia, hypothermia, and cyanosis

Ideal position for CPR

Right lateral recumbency

Where should compressions be performed on the patient?

7kg and less - thumb on one side of chest, other fingers on other side




Over 7kg - 4th and 6th intercostal space and the costochondral junction

Epinephrine use in CPR

Positive inotrope (force of contraction), chronotrope(rate) and possesses potent vasoconstrictor effects. Epinephrine can induceventricular fibrillation

Arginine vasporessin use in CPR

This drug induces marked peripheral vasoconstriction, improving cerebral and coronary perfusion. There are no direct cardiac effects with vasopressin. Unlike all other drugs used in CPCR, vasopressin maintains its effectiveness in hypoxemic and acidemic states

Atropine use in CPR

Anticholinergic that decreases vagal tone andmay halt the progression of unstable bradycardia to asystole in the arrestingpatient. This drug increases sinoatrial node automaticity and atrioventricularconduction

Amiodarone use in CPR

Class III antiarrhythmic that prolongs bothaction potential duration and refractory period. This is the recommended drugfor treatment of continued ventricular fibrillation after defibrillation

Cranial Nerve I

Olfactory Nerve




Mediates the sense of smell, observed when the pet sniffs around its environment

Cranial Nerve II

Optic Nerve




Carries visual signals from retina to occipital lobe of brain, observed as the pet tracks an object with its eyes. It also causes pupil constriction. The Menace response is the waving of the hand at the dog’s eye to see if it blinks

Cranial Nerve III

Oculomotor Nerve




Provides motor to most of the extraocularmuscles (dorsal, ventral, and medial rectus) and for pupil constriction

Cranial Nerve IV

Trochlear Nerve




Provides motor function to the dorsal oblique extraocular muscle and rolls globe medially

Cranial Nerve V

Trigeminal Nerve




Provides motor to muscles of mastication (chewing muscles) and sensory to eyelids, cornea, tongue, nasal mucosa and mouth

Cranial Nerve VI

Abducens Nerve




Provides motor function to the lateral rectus extraocular muscle and retractor bulbi




Examined by touching the globe and observing for retraction (also tests V for sensory)

Cranial Nerve VII

Facial Nerve




Provides motor to muscles of facial expression (eyelids, ears, lips) and sensory to medial pinna (ear flap). Also taste to rostral tongue

Cranial Nerve VIII

Vestibulocochlear Nerve




Sensory for hearing and head position

Cranial Nerve IX

Glossopharyngeal Nerve




Innervates the pharynx for swallowing (with X). Also innervates some salivary glands and provides taste innervation from caudal tongue




Examine by eliciting a gag reflex and observing for dysphagia (difficulty swallowing)

Cranial Nerve X

Vagus Nerve




Innervatesthe larynx, esophagus, and pharynx. Also provides parasympathetic innervationto the heart and viscera Tested with a gagreflex


Cranial Nerve XI

Spinal Accessory Nerve




Innervates cranial cervical muscles

Cranial Nerve XII

Hypoglossal Nerve




Motor to the tongue

Apical

toward the root

Attrition

wearing of the teeth from mastication or teeth rubbing together

Buccal

direction toward the cheek

Calculus

calcified plaque which hardens on the tooth and may not be brushed off

Cementum

hard connective tissue covering the tooth root and sometimes the crown

Crown

portion of the tooth that sits above the gumline and is covered in enamel

Dentin

the bulk of the tooth; the hard connective tissue of the tooth made mostly of calcium and collagen

Enamel

the white hard outer layer of the crown (made mostly of calcium)

Endodontics

treatment involving the pulp cavity (i.e. root canal procedure)

Floating

smoothing a horse’s teeth with a file (called a float) to rid of sharp edges

Gingiva

mucosa surrounding the teeth (gums around theteeth)

Halitosis

Bad Breath

Lingual

direction toward the tongue

Malocclusion

abonormal position of the teeth

Occlusal

regarding the tooth surface that meets tooth surface on the opposite jaw

Periodontal ligament

collagen fiber which attaches tooth to the bone (holds tooth in place)

Periodontium

supportive tissues around the tooth including bone of alveolus, periodontal ligament, cementum, and gingiva

Plaque

a film which accumulates on the tooth made of food, bacteria, cells, and mucin

Pulp

the soft part inside the tooth made of nerves, vessels, odontoblasts, connective tissues and lymphatics

Ranula

a salivary cyst under the tongue

Recession

apical gingival movement away from the tooth crown

Root

lower part of the tooth that is in the alveolus

Stomatitis

inflammation of the soft tissues in the mouth

Sulcus

pocket under the gingiva; normal is 0-3 mm, greater than this suggests periodontal disease

Hypsodont

High crowned teeth seen in horses, cattle and deer

Radicular

Continuously erupting like rodents, rabbits and chinchillas

Aradicular

Continuously growing

Brachydont

Low-crowned teeth seen in cats and dogs

Dog dental formula

3142, 3143

Cat dental formula

3131, 3121

Ruminant dental formula

0033, 3133

Horse dental formula

3133, 3143

Pig dental formula

3143, 3143

Rabbit dental formula

2033, 1023

Rat/mouse dental formula

1003, 1003

Key signs of diabetes mellitus

PU/PD, polyphagia, weight loss




Can include cataracts

Type I diabetes

No longer producing insulin

Type II diabetes

Insulin resistance (rare in dogs, common in cats)




Some cats can go into diabetic remission

"Healthy diabetic" clinical signs

PU/PD, polyphagia, recurrent infections, plantigrade stance (cats), cataracts (dogs)

"Severe" diabetic ketoacidosis (DKA)

Anorexia, vomiting, weakness, metabolic acidosis, blood glucose > 500 mg/dl, may have previous history of the signs of a healthy diabetic

Clinical signs of diabetes

Hyperglycemia, glocosuria

Treatment of diabetes mellitus

Insulin injections - BID, SQ by owner


High fiber, low fat/carb diet




*Oral hypoglycemics are not effective in pets!!

Short-acting insulin

Hummulin-R - used for diabetic ketoacidosis (DKA)

Intermediate or longer acting insulins

Hummulin-N, Vetsulin - used for maintenance therapy

Dog and cat flea

Ctenocephalides felis or canis

Xenopsylla cheopis

Rat flea known for plague organism Yersinia pestis

Female fleas lay around ___ eggs a day

50

Ixodes

Deer tick - transmits lyme

Dermacentor

American dog tick - transmits Rocky Mountain Spotted Fever (Rickettsia rickettsii)

Rhipicephalus

Brown dog tick - transmits Ehrlichia spp.

Capitulum

Tick mouth parts

Otobius megnini

Ear tick

Demodex mites

"Deep" mites, treated with oral ivermectin or lyme sulfur dip

Scabies

Pruritic, zoonotic (self-limiting), multiple scrapes necessary, treated with selamectin, lime sulfur dips or milbemycin. Sarcoptes scabiei is canine mite, Notoedres cati is the feline mite

Cheyletiella

Walking dandruff, superficial mite, very pruritic

Ear mites

Otodectes cynotis is ear mite of cats and dogs, treated with topical ivermectin

Lice

Infestation with lice is known as pediculosis. Pruritic, transmitted via direct contact. Uncommon, may be biting or sucking in nature. Treated with fipronil or selamectin.




Trichodectes canis (chewing) and Linognathus setosus (sucking are found in canines.




Hematopinus (sucking) are found in cattle

Strongylus vulgaris

Larvae penetrate submucosal arteries and migrate along endothelium to the cecal and colic arteries and then to the base of the cranial mesenteric artery; they return to the intestine via the arteries

Strongylus edentatus

Larvae invade gut wall and penetrate blood vessels and migrate to liver via the hepatic portal vein; larvae then travel through the liver and return to the large intestine via the mesentery.



Migration may or may not result in observable clinical signs

Strongylus equinus

During maturation, larvae leave intestine and migrate to the liver; from there they migrate back to the large intestine



Migration may or may not result in observable clinical signs

Anoplocephala perfoliata

May or may not be a common cause of colic in thehorse




Inhabits the region of the ileocecal junction and can produce ulcerations of the mucosa



Parascaris equorum

P. equorum (also known as roundworms or ascarids) cause disease in foals and is not a significant parasite in the adult horse (adult horses develop immunity to ascarids and thus are not associated with disease in adults)

Cyathostomes

Known as small stronglyes, include a number of species (40+) and can cause severe diarrhea in adult horses (larval cyathostomiasis). Typically occurs in the late winter or spring and is associated with the simultaneous emergence of a large number of fourth-stage larvae from the intestinal mucosa

Dictyocaulus arnfieldi

Equine lung worm




Commonly seen in donkeys, but rarely produce clinical signs.




If seen in horses, can be more sever and result in bronchial inflammation and chronic cough

Right side of horse

Far side

Left side of horse

Near side - standing side

Crystalloids

Crystalloids are solutions that are isotonic with plasma and contain sodium as the major osmotically active particle. Lactated Ringer’s Solution, 0.9% Sodium Chloride (Normal Saline), and Normosol-R are isotonic crystalloid solutions

Maintenance Rate

60ml / kg / day

Anesthetic Rates

10ml / kg / hr for dogs


5ml / kg / hr for cats

Shock Rates

90ml / kg in dogs


45ml / kg in cats

Dextrose Solutions

Formed when dextrose is added to a crystalloid. Dextrose provides an intracellular carbohydrate source in septic patients and aids correction of hypoglycemia

Synthetic Colloids

Act primarily to expand plasma volume. Useful as resuseitative or replacement fluids and can be given as a boluis if patient has poor perfusion due to hypovolemia




Hetastarch, Dextrans 40 and Dextrans 70

Hetastarch maintenance rate

20ml / kg / day

Colloids

Used for the relative expansion of the interstitial space in the event of a plasma volume deficiency resulting from traumatic or septic shock, and replacement of lost blood volume. Colloid solutions include human and canine albumin, fresh frozen plasma, and whole blood

Dry or sticky oral mucous membranes

5% - 6% dehydration

Mild to moderate decrease in skin turgor, dry or “sticky” oral mucous membranes, sunken eyes

6% - 8% dehydration

Marked decrease in skin turgor, dry mucousmembranes, sunken eyes, weak and rapid pulses, slow capillary refill time,moderate to marked mental depression

10% - 12%

Signs of OVER hydration

Serous nasal discharge, subcutaneous edema, increased urine output, ascites, coughing/pulmonary edema, increased respiratory rate

GDV

Gastric Dialation Volvulus

What does GDV look like on radiograph

Right lateral is best




Gastric compartmentalization of air, or "double bubble"

A Great Dane is predisposed with a ___% chance of developing a GDV

37%

Clinical Signs of GDV

Restless/nervous pacing/painful, non productive retching, abdominal distension, increased respiratory rate, tachycaardia, weak pulses, pale mucus membranes, prolonged CRT, depressed mentaion

Pros and cons of an orograstric tube in patient with GDV

More effective emptying




Requires heavy sedation, tube might not pass, possible esophageal trauma

Pros and cons of trocarization in patient with GDV

More rapid intervention, doesn't require sedation




Limited decompression, risk of lacerating gastric wall, puncturing speleen

Negative prognostic indicators for GDV

Lactate > 6 mmol/L


Need for gastric resection/splenectomy


Long onset of signs to time of presentation (5-6 hrs)


Recumbency at presentation

Recurrence of GDV? %

If gastropexy is performed, recurrence is less than 4%




If not, recurrence is 50%

Nematode - Roundworms

Toxocara


Most common in cats and dogs


Causes zoonotic disease ocular larval migrans


Treated with piperazine, pyrantel or fenbendazole


Transmitted fecal-oral route, or trans-placental


Live in small intestine

Nematode - Hookworms

Ancylostoma and Uncinaria


Causes zoonotic disease cutaneous larval migrans


Treated with fenbendazole, pyrantel


Transmitted fecal-oral route, transmammary or percutaneous infections


Percutaneous = migrate through skin, to lung where coughed up and swallowed into the small intestine

Nematode - Whipworms

Trichuris vulpis


Transmitted fecal-oral route


Can cause hyperkalemia and hyponatremia


Treated with fenbendazole

Cestodes - Tapeworm

Dipylidium caninum transmitted by flea as host


Taenia are transmitted by ingestive of hydatid cysts during predation


Proglottid segments are released from the end of the worm and shed in feces


Treated with praziquantel

Trematodes - Flukes

Fasciola hepatica - liver fluke


Parasite most common in areas of high rainfall or moist environments


Treated with albendazole

Giardia

Protozoan


Treated with fenbendazole or metronidazole

Coccidia

Isospora- most common in dogs and cats


Eimeria - most common in poultry/birds, rabbits


Treated with sulfadimethoxine (albon)

Soft palate

Separates the oropharynx and the nasopharynx

Oropharynx

Part of pharynx between the tongue and soft palate

Two layers of lining in the esophagus

Mucosa and submucosa

Two layers of muscle in the esophagus

Longitudinal and the circular

4 stomachs of ruminants

Reticulum, rumen, omasum, abomasum

Monogastric stomach parts

Fundus, body, antrum

Function of stomach

Produces hydrochloric acid (via parietal cells) which aids in breakdown of food. pH of stomach is tightly controlled by active transport. Enzymes, mostly pepsin, breakdown proteins into amino acids. Stomach also produces a layer of mucus made up mostly of mucin and bicarbonate to protect itself from acidity

3 parts of small intestine

Dudenum, jejunum, ilieum

Parts of large intestine

Cecum and colon

Cecum

Blind sac that is less developed in dogs and cats bu is advanced in the ruminant




In the horse and cattle, referred to as the "hindgut" - fermentation occurs here in cow

Colon

Tubular organ that uses peristaltic and segmental contraction




Absorb nutrients and water not already absorbed by small intestine and stores feces

Drug to treat heartworm disease

Melarsomine

Wohlbachia

Bacterium that infects the heartworm itself. Doxycycline is given to pet to prevent secondary bacteria infection

Signs of heartworm in dogs

Exercise intolerance, cough, dyspnea, ascites

Signs of heartworm in cats

Salivation, tachycardia, shock, neurologic symptoms, or sudden death

Diagnosis of heartworm disease

Heartworm antigen test, right sided cardiac enlargement on radiograph, enlarged pulmonary arteries, proteinuria or increased eosinophil count

Treatment of heartworm disease

Single injection of melarsomine followed by 2 injections 24 hours apart 4-6 weeks later

Red blood cell parameters of a CBC consist of:

RBC count


Hemoglobin measurement (Hgb)


Hematocrit measurement (Hct)


Mean corpuscular volume measurement (MCV)


RBC distribution width measurement


Mean Corpuscular hemoglobin (MCH) measurement


Mean corpuscular hemoglobin concentration (MCHC)


Comments on RBC morphology

White blood cell parameters of a CBC consist of

WBC count


Differential count of neutrophils, lymphocytes, monocytes, eosinophils, basophils

Platelet parameters of a CBC consist of

Platelet count


Mean platelet volume (MPV)


Comments on platelet morphology

Anemia

Decreased number of RBC's

Polycythemia

Increased number of RBC's

Rouleaux

RBC's that form stacks

Agglutination

RBC's that form irregular clumps

Microcytosis

Decreased RBC size

Macrocytosis

Increased RBC size

Ansiocytosis

Increased variation in cell size

Hypochromia

Decreased pigment (increased pallor)

Hyperchromia

Increased pigment (lack of central pallor)

Ansiochromasia

Increased variation in pigmentation

Polychromasia

RBC's with a blue or lilac tinge

Poikilocytosis

Increased variation in RBC shape

Spherocytosis

Cells that are spherical in shape with lost central pallor

Target cell

Cell with strongly staining area in the middle of the central pallor region

Schistocyte

Fragmented RBC's that are usually angluar

Echinocyte

Creneated RBC with many (20-30) small, regular, blunt projections

Acanthocyte

Cell with irregularly distributed small projections

Howell-Jolly bodies

Round dense staining inclusions, usually toward one edge of the cells; represents a nuclear fragment

Basophilic stippling

Presence of the small basophillic inclusions distributed throughout the RBC; represents abnormally staining ribosomes

Nucleated RBC's

RBC's that have not complete maturation and still have a nucleus

Cytoplasmic basophilia

Streaky diffuse blue appearance to cytoplasm

Dohle bodies

Round to linear blue aggregates in the cytoplasm

Cytoplasmic vacuolation

Indistinct vacuoles throughout the cytoplasm creating a frothy appearance

Nucelear immaturity

Less clumped chromatin in the nucleus

Macroplatelets

Larger than normal platelets

Hyperadrenocorticism

Cushing's Disease

What causes Cushing's disease?

Excessive circulating cortisol

Where is cortisol produced?

Adrenal gland

What signals the adrenals to continue and produce cortisol?

The pituitary secretes ACTH

Symptoms of Cushing's disease

PU/PD, pot belly appearance, hair loss, calcinosis cutis, excessive panting, may have concurrent hypertension

Laboratory findings for Cushing's Disease

Elevated ALKP, +/- proteinuria, dilute urine, prone to UTI's

Diagnosis of Cushing's

Testing is with the ACTH stimulation test




Low-Dose Dexamethasone Suppression test (if differentiating pituitary vs. adrenal cause)

Treatment of Cushing's

Trilostane (Vetoryl) - Inhibits steroid synthesis and doesn't usually cause permanent change in adrenal gland




Lysodren (mitotane) - destroys part of adrenal cortex to prevent cortisol production, but may cause more side effects that can lead to hypoadrenocorticism

Equine Cushing's

May have hirsutism (abnormal long and wavy haircoat), and other symptosm associated with dogs

The thyroid gland synthesizes what hormones

Thyroxine (T4) and Triiodothyronine (T3) which incorporate iodine

Clinical signs of hyperthyroidism

Weight loss with ravenous appetite


Thyroid nodule


Hyperactivity


Vomiting/increased vocalizing


Tachycardia, and possibly heart murmur or gallop (thyrotoxic cardiomyopathy)

Diagnosis of hyperthyroidism

Serum total T4 levels

Treatment of hyperthyroidism

Oral or transdermal methimazole (can cause facial exoriations)




Thyroidectomy




Radioactive iodine - single dose, requires hospitalization

Hypoadrenocorticism

Addison's Disease

What causes Addison's disease?

Inability of the adrenal glands to produce cortisol

Clinical signs of Addison's disease

Weakness, vomiting, diarrhea, finicky appetite, dehydration, bradycardia and low blood pressure

Laboratory findings of Addison's disease

Elevated potassium, low sodium and chloride




Hypoglycemia, increased BUN and creatinine due to decreased renal perfusion

Diagnosis of Addison's disease

ACTH Stimulation test

Treatment of Addison's disease

Steroids, only after ACTH stimulation test has been performed

What causes hypothyroidism

When thyroid glands produce insufficient levels of thyroid hormone

Clinical Signs of hypothyroidism

Weight gain, obesity, lethargy, alopecia (bilaterally symmetic over the lateral trunk, tail and ventral thorax), heat-seeking, muscle weakness, skin disease

Diagnosis of hypothyroidism

Serum total T4 levels

Treatment of hypothyroidism

Oral levothyroxine

What is plasma composed of?

90% water, 10% proteins, carbs, vitamins, hormomes, fats, salts, enzymes and wastes

What is serum?

Plasma that has had fibrinogen removed

EDTA tube

Prevents coagulation by binding to calcium ions

Red-top tube

Glass tubes have no additive, plastic tubes have clot activators

Tiger-top tube

Serum separator tubes - contains clot activator gel

Light blue-top tube

Contains sodium citrate, anticoagulant that binds calcium




Used to check for coagulation disorders such as PT, PTT, FDP, D-dimer, and von Willebrand factors

Green-top tube

Plasma separator tubes


Contain heparin, which activates antithrombins, which block coagulation

Gray-top tube

Contain sodium fluoride, which is a glucose preservative, and some contain potassium oxalate




Used if accurate glucose measurement is needed and sample processing will be delayed

What is needed for skeletal muscle contraction?

ATP and calcium

The neurotransmitter for skeletal muscles

Acetylcholine (ACH)

Skeletal muscle activity is ceased by

Acetylcholinesterase

Neurotransmitter for smooth muscles

Acetylcholine or norepinephrine

Sarcomere

Contractile unit of a muscle fiber

Myofibril

Muscle fiber

Sarcoplasmic reticulum

Endoplasmic reticulum that is needed for muscle contraction

Z-line

Protein bands where actin filaments attach in a striated muscle fiber and mark the boundaries of adjoining contractile units

Sarcolemma

Thin plasma cell membrane of a muscle cell

Orbit

Hole in which the eye sits surrounded and formed by the maxilla, zygomatic, frontal and ethmoid bones

Term for eyelids

Palpebrae

Conjunctiva

Membrane that lines the insides of the eyes and eye itself - secretes mucus that lubricates the eye

Lacrimal gland

Makes tears which are secreted through lacrimal ducts

Third eyelid

Nictitating membrane - near medial canthus and sometimes protrudes

Sclera

White part of eyeC

Cornea

Clear and retracts light - no vessls

Uvea

Vascular tunic made of choroid, ciliary body and iris

Iris

Colored part of eye

Ciliary body

Helps focus the eye

Choroid

Guards against glare

Pupil

Central part of the iris where light passes through

Retina

Where images are formed, made of rods and cones (mostly rods in dogs)

Tapetum

Reflective layer that helps animals see in dim light

Fundus

Part of posterior eye segment that is viewed with the opthalmascope

Lens

Circular and transparent disc made of protein with no blood supply

Anterior chamber of eye

Filled with aqueous humor related to intraocular pressure

Posterior chamber of eye

Located between iris, lens and ciliary body - has vitreous humor which keeps retina intact

Schirmer Tear Test

A small strip of designated STT paper is placed under the lower lid of each eye. The dye in the paper will begin to turn color as tears are produced

Normal tear production

Greater than 15 mm in 60 seconds

Fluoroscein Dye Stain Test

A small amount of yellow fluoroscein stain is applied to the eyes. If there is a corneal defect or scratch, the dye will glow under a blue light. This is the test for a corneal ulcer or abrasion

Tonometry

Tonopen is used to measure intraocular pressures. The reading should be taken 3 times or more to ensure accuracy. High pressures suggest glaucoma. This is the test for glaucoma. A low pressure suggests uveitis, or inflammation in the eye

Normal eye pressures

Less than 25

Miosis

Small or constricted pupil

Mydriasis

Dilated pupil

Anisocoria

Different sized pupils

Pupillary Light Reflex

Pupils should constrict in light and dilate in dark

Enucleation

Surgical removal of eye

Proptosis

Eye that has been popped out of socket

Hyphemia

Blood in the anterior chamber of eye

Hypopion

Puss in the anterior chamber of the eye

Entropion

Rolling in of the eyelids

Cherry eye

Prolapsed gland of the third eyelid

Canthus

Corner of the eye

Whelping

Act of dog giving birth

Queening

Act of cat giving birth

Parturition

General term for birth

Maltiparous

Having two or more offspring at birth

Colostrum

Early milk that is rich in antibodies and protein

Dystocia

Difficult birth

Gestation length of dogs and cats

60-63 days

Stage 1 of labor

Restless, may seek seclusion or refuse food. This stage may last for 6-24 hours

Stage 2 of labor

Contractions begin. A small fluid-filled sac protrudes from the vulva, encompassing the puppy, and has attached placenta. Puppies normally are nose first with abdomen down. Up to 1/3 of puppies may present with hindquarters first (breech)

Stage 3 of labor

Resting stage in between each delivery. Expulsion of afterbirth. May last 10 minutes or less, or up to an hour

Natural Birth Care

Mother should lick or chew the sac open




Neonate should have mouth suctioned and stimulated with a towel




Encourage neonate to suckle on mother immediatley - causes oxytocin release in the mother and helps with uterine contractions and milk letdown

Cesarean Section Care

Mouth should be suctioned several times to remove mucus, and neonates should be stimulated with warm towels




Doxapram (dopram) can be administered orally to stimulate breathing

Nutrition for after birth

For lactating mother, 2-3 times normal (give puppy food), until puppies are weaned

When should weaning begin?

Around 5 weeks of age

When assistance should be necesary in delivery of neonates

Stuck in canal for longer than 5 minutes


Strong contractions for 30 minutes and no delivery


Labor is weak and goes on for 3-4 hours without delivery


More than 4 hours have passed and more puppies are expected


Mom has been pregnant for more than 65 days


Dark discharge and no delivery or labor in 3-4 hours

Eclampsia

The bitch is losing more calcium in the milk than she is taking in. Signs of this are muscle twitching, seizures, drooling, fever, extreme restlessness, or panting. This is lifethreatening, and the pet should receive immediate veterinary attention

Mastitis

Infection of a mammary gland. May cause lethargy and fever. The gland becomes hard, may be purple or red in color, and may have a foul smell or abnormal color to the milk; is typically painful.

What should be given to orphaned puppies?

Fed milk replacer (Esbilac for dogs and KMR for cats)




Do not give cow's milk

When do puppies and kittens open their eyes?

10-14 days of age

Toxin: Lilies

Toxic to cats


Causes acute renal failure within 18-72 hours

Toxin: Ethylene Glycol

Antifreeze


Causes acute renal failure


Causes metabolic acidosis

Toxin: Rodenticide

Contains anticoagulant which is Vitamin K antagoinst


Treated with emesis


Signs may not be evident for 4-5 days after ingestion


Causes spontaneous bleeding

Toxin: Metaldehyde

Found in snail bait


Causes anxiety, ataxia, hyperesthesia, muscle twitching or seizures, tachycardia, dilated pupils, hypersalivation, and vomiting or diarrhea; pets often present seizuring and have a high temperature; vomitus often contains green pellets which are usually snail bait

Toxin: Pyrethrin

Most often seen in kittens or cats that have recently had an over-the-counter topical flea treatment

Toxin: Acetaminophen

Tylenol is very toxic to cats as it causes methemoglobin formation; in dogs it may be primarily toxic to the liver at higher doses



It causes Methemoglobinuria in cats and may cause the urine to appear brown, the gums to appear brown or cyanotic, and may cause peripheral edema




Toxic dose in dogs 150 mg/kg, toxic dose in cats50 mg/kg

Toxin: Chocolate

Toxic agents in chocolate are theobromine and caffeine



Causestachycardia, CNS excitability/tremoring, excitement, and if severe enough canresult in death within 6-24 hours




TheLD50 of theobromine and caffeine is 100-200 mg/kg




Treatment isinduction of emesis, fluid therapy, and activated charcoal

Toxin: Grapes and Raisins

May contain oxalates that can damage the kidneys



Can cause renal failure in some patients depending on genetic predisposition and quantity ingested, etc



Toxin: Onions

May cause Heinz Body anemia

Clinical Signs of Rabies

Behavior change or vocalization


Lameness


Acute or progressive signs


Asymptomatic for 1-2 months


Dumb and furious forms (hypersalivation vs aggressive)

Diagnosis of Rabies

Direct Fluorescent Antibody Test

Unit of abosrbed dose equivalent used for radiation safety

Seivert (Sv)

Maximum permissible dose limits for exposure

Whole body = 50 mSv (5 rem)


Skin and extremities = 500 mSv (50 rem)


Eye or lense = 150 mSv (15 rem)

Sante's Rule

2 (tissue thickness in cm) + SID + grid factor = kVp setting

X-ray film too black?

Lower kVp

X-ray film too white?

Increase kVp

Nephron

Functional unit of the kidney

Renin

Secreted by the kidney; mediates extracellular volume and arterial vasoconstriction (regulates blood pressure), via the renin-angiotensin system

Aldosterone

Stimulates active sodium resorption

Antidiuretic hormone (ADH)

Stimulates passive water re-absorption

Function of Kidney

Regulating water and electrolyte balance

Maintains acid:base homeostasis


Aids in retaining protein and glucose in the body


Excretes wastes and toxins


Plays a role in many endocrine functions by secreting hormones

Prostate gland

Only accessory gland in dog

Bulbourethral gland

Present in domestic animals except the dog

Polyestrous

2 or more estrous cyclesS

Seasonally polyestrous

Cycles only during certain parts of the year

Diestrous

Resting period between cycles

Monoestrous

Single estrous cycle in a year

Anestrus

Not ovulating, not sexually receptive

Rabbit gestation period

30-32 days

Horse gestation period

320-346 days

Cows

271-291 days

Sheep

143-151 days

Ferrets

42 days

Metabolic Bone Disease

In lizards, malnutrition and lack of exposure to UVB light(either from sunlight or artificial bulbs). This leads to decreased synthesisof vitamin D3. Vitamin D3 is essential for calcium absorption and metabolism.Low levels of vitamin D3 impairs calcium absorption and metabolism. Patientswith metabolic bone disease may exhibit the following clinical signs: weakness,lethargy, stunted growth, muscle fasciculations, abnormal gait or posture,fractures, soft mandible (rubber jaw). Without treatment and correct husbandrythis condition is fatal